Investigation of the Muscle Oxygenation in Patients With Post COVID-19 Syndrome
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ClinicalTrials.gov Identifier: NCT05957575 |
Recruitment Status :
Completed
First Posted : July 24, 2023
Last Update Posted : August 2, 2023
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Condition or disease |
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COVID-19 |
Post-COVID syndrome is defined as unexplained signs or symptoms that develop during or after infection with COVID-19 and persist for 12 weeks. Long-term symptoms include fatigue, dyspnea, impaired exercise and lung function.It is important to understand physiological mechanisms underlying persistent dyspnea, fatigue, and impaired exercise capacity after COVID-19 infection to develop appropriate rehabilitation interventions while improving these symptoms. The pathophysiology of long-term persistent symptoms is largely unknown, however hypoxia and hypoxic tissue damage caused by COVID-19-associated pneumonia, decreased pulmonary diffusion capacity, ventilation-perfusion mismatch and lung fibrosis have been hypothesized. The effect of hypoxemia associated with COVID-19 on oxygenation of peripheral muscles and muscle oxygenation at submaximal and maximal exercise intensity has not been investigated, yet.
The aim of our study is to evaluate and compare quadriceps femoris muscle oxygenation in submaximal and maximal exercise tests in patients with post-COVID syndrome.
Patients referred from Gazi University, Faculty of Medicine, Department of Chest Diseases for pulmonary rehabilitation to Cardiopulmonary Rehabilitation Unit located in the Faculty of Health Sciences were recruited, Department of Physiotherapy and Rehabilitation, between March 2022 and May 2023. Muscle oxygenation during six-minute walk test and cardiopulmonary exercise test on two different days was measured and compared.
Study Type : | Observational [Patient Registry] |
Actual Enrollment : | 39 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Target Follow-Up Duration: | 2 Days |
Official Title: | Comparison of the Muscle Oxygenation During Submaximal and Maximal Exercise Tests in Patients With Post COVID-19 Syndrome |
Actual Study Start Date : | February 25, 2022 |
Actual Primary Completion Date : | June 15, 2023 |
Actual Study Completion Date : | July 20, 2023 |
- Measurement of muscle oxygenation (SmO2) [ Time Frame: through study completion, an average of 18 months ]The saturation of oxygen in muscles (SmO2) was evaluated using a non-invasive method Moxy® device (Moxy®, Fortiori Design LLC, Minnesota, USA).
- Maximal exercise capacity [ Time Frame: through study completion, an average of 18 months ]Cardiopulmonary Exercise Test
- Submaximal exercise capacity [ Time Frame: through study completion, an average of 18 months ]Six minute walk test
- Peripheral Muscle Strength [ Time Frame: through study completion, an average of 18 months ]Hand held dynamometer
- Functional Status [ Time Frame: through study completion, an average of 18 months ]Post-COVID-19 Functional Status scale (PCFS)
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Ages Eligible for Study: | 18 Years to 75 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Probability Sample |
Inclusion Criteria:
- Between the ages of 18-75
- Diagnosed with pulmonary involvement COVID-19
- Volunteer to participate in the study
Exclusion Criteria:
- Body mass index >35 kg/m2
- Acute pulmonary exacerbation, acute upper or lower respiratory tract infection
- Aortic stenosis, complex arrhythmia, aortic aneurysm
- Serious neurological, neuromuscular, orthopedic, other systemic diseases or other diseases affecting physical functions
- Cognitive impairment that causes difficulty in understanding and following exercise test instructions
- Participated in a planned exercise program in the last three months
- Uncontrolled hypertension and/or diabetes mellitus, heart failure and cardiovascular disease
- Contraindication for exercise testing and/or exercise training according to the American College of Sports Medicine
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT05957575
Turkey | |
Gazi University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Cardiopulmonary Rehabilitation Clinic | |
Ankara, Turkey, 06560 |
Principal Investigator: | Başak KAVALCI KOL, Pt. MSc. | Gazi University | |
Principal Investigator: | Ece BAYTOK, Pt. MSc. | Gazi University | |
Principal Investigator: | Nilgün YILMAZ DEMİRCİ, Assoc. Prof. | Gazi University | |
Study Director: | Meral BOŞNAK GÜÇLÜ, Prof. Dr. | Gazi University |
Responsible Party: | Meral Boşnak Güçlü, Study director, PT, PhD, Prof.Dr. Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Head of Cardiopulmonary Rehabilitation Clinic, Gazi University |
ClinicalTrials.gov Identifier: | NCT05957575 |
Other Study ID Numbers: |
Gazi University 5 |
First Posted: | July 24, 2023 Key Record Dates |
Last Update Posted: | August 2, 2023 |
Last Verified: | July 2023 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | No |
Studies a U.S. FDA-regulated Drug Product: | No |
Studies a U.S. FDA-regulated Device Product: | No |
COVID-19 oxygen consumption |
COVID-19 Pneumonia, Viral Pneumonia Respiratory Tract Infections Infections Virus Diseases |
Coronavirus Infections Coronaviridae Infections Nidovirales Infections RNA Virus Infections Lung Diseases Respiratory Tract Diseases |