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Nationwide Trends in Incidence, Healthcare Utilization, and Mortality in Hospitalized Acute Myocardial Infarction Patients in Taiwan

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ClinicalTrials.gov Identifier: NCT05974397
Recruitment Status : Completed
First Posted : August 3, 2023
Last Update Posted : August 3, 2023
Sponsor:
Information provided by (Responsible Party):
Novartis ( Novartis Pharmaceuticals )

Study Description
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Brief Summary:

This was a retrospective study using the Taiwan's National Health Insurance Research Database (NHIRD). The study employed two study designs for different purposes as follows:

  • A cross-sectional analysis was conducted to explore the annual incidence trends.
  • A longitudinal cohort study was conducted to assess baseline characteristics, treatment patterns, long-term healthcare utilization, and cause-specific mortality among incident AMI patients.

In each part, the study was conducted for AMI, and separately for ST-segment elevation and non-ST- segment elevation myocardial infarction (STEMI and NSTEMI)


Condition or disease
Acute Myocardial Infarction

Study Design
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Study Type : Observational
Actual Enrollment : 124018 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Nationwide Trends in Incidence, Healthcare Utilization, and Mortality in Hospitalized Acute Myocardial Infarction Patients in Taiwan
Actual Study Start Date : September 30, 2021
Actual Primary Completion Date : July 22, 2022
Actual Study Completion Date : July 22, 2022

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Heart Attack

Groups and Cohorts
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Group/Cohort
AMI
Patients with AMI
STEMI
Patients with STEMI
NSTEMI
Patients with NSTEMI


Outcome Measures
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Primary Outcome Measures :
  1. Mean age of patients [ Time Frame: 12 months ]
  2. Number of male patients [ Time Frame: 12 months ]
  3. Year of patient entry into cohort [ Time Frame: 12 months ]
  4. Number of patients with AMI in Taiwan [ Time Frame: 12 months ]
  5. Number of patients with STEMI in Taiwan [ Time Frame: 12 months ]
  6. Number of patients with NSTEMI in Taiwan [ Time Frame: 12 months ]
  7. Number of AMI patients with comorbidities [ Time Frame: Up to 3 years ]
  8. Number of patients with treatment for AMI [ Time Frame: Up to 3 years ]
  9. Number of STEMI patients with comorbidities [ Time Frame: Up to 3 years ]
  10. Number of patients with treatment for STEMI [ Time Frame: Up to 3 years ]
  11. Number of NSTEMI patients with comorbidities [ Time Frame: Up to 3 years ]
  12. Number of patients with treatment for NSTEMI [ Time Frame: Up to 3 years ]
  13. Number of mortalities among AMI patients [ Time Frame: Up to 3 years ]
  14. Number of mortalities among STEMI patients [ Time Frame: Up to 3 years ]
  15. Number of mortalities among NSTEMI patients [ Time Frame: Up to 3 years ]
  16. Number of AMI patients with outpatient visits [ Time Frame: Up to 3 years ]
  17. Number of AMI patients with emergency room visits [ Time Frame: Up to 3 years ]
  18. Number of AMI patients with hospitalizations [ Time Frame: Up to 3 years ]
  19. Length of hospital stay for AMI patients [ Time Frame: Up to 3 years ]
  20. Direct medical costs for AMI patients [ Time Frame: Up to 3 years ]
  21. Number of STEMI patients with outpatient visits [ Time Frame: Up to 3 years ]
  22. Number of STEMI patients with emergency room visits [ Time Frame: Up to 3 years ]
  23. Number of STEMI patients with hospitalizations [ Time Frame: Up to 3 years ]
  24. Length of hospital stay for STEMI patients [ Time Frame: Up to 3 years ]
  25. Direct medical costs for STEMI patients [ Time Frame: Up to 3 years ]
  26. Number of NSTEMI patients with outpatient visits [ Time Frame: Up to 3 years ]
  27. Number of NSTEMI patients with emergency room visits [ Time Frame: Up to 3 years ]
  28. Number of NSTEMI patients with hospitalizations [ Time Frame: Up to 3 years ]
  29. Length of hospital stay for NSTEMI patients [ Time Frame: Up to 3 years ]
  30. Direct medical costs for NSTEMI patients [ Time Frame: Up to 3 years ]

Eligibility Criteria
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Ages Eligible for Study:   20 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
This was a retrospective, noninterventional cohort study.
Criteria

Inclusion Criteria:

Cross-sectional analysis:

  • Patients aged 20 years and older.
  • Patients who had been admitted for AMI, defined as primary or first secondary diagnosis of AMI between 2014 and 2020.
  • The diagnosis of AMI/ STEMI/ NSTEMI was identified by the International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) codes and 10th revision (ICD-10-CM) codes.
  • Incident cases of AMI hospitalization were defined as no history of AMI-related hospitalization or outpatient visit within 1 year before admission.

Longitudinal analysis:

Patients aged 20 years and older.

  • Patients who had been admitted for AMI, defined as primary or first secondary diagnosis of AMI between 2014 and 2017.
  • The diagnosis of AMI/ STEMI/ NSTEMI was identified by ICD-9-CM codes and ICD-10-CM codes. (The ICD-9-CM code and ICD-10-CM codes were the same as above)
  • Incident cases of AMI hospitalization were defined as no history of AMI-related hospitalization or outpatient visit within 1 year before admission.
  • The cohort entry date was defined as the admission date of incident AMI hospitalization, and the index date was defined as the discharge date of incident hospitalization.

Exclusion Criteria:

None specified

Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT05974397


Locations
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Taiwan
Novartis
Taipei, Taiwan
Sponsors and Collaborators
Novartis Pharmaceuticals
Investigators
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Study Director: Novartis Pharmaceuticals Novartis Pharmaceuticals
More Information
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Top of Page Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information
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Responsible Party: Novartis Pharmaceuticals
ClinicalTrials.gov Identifier: NCT05974397    
Other Study ID Numbers: CLCZ696BTW05
First Posted: August 3, 2023    Key Record Dates
Last Update Posted: August 3, 2023
Last Verified: July 2023
Additional relevant MeSH terms:
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Myocardial Infarction
Infarction
Ischemia
Pathologic Processes
Necrosis
 Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases