Relationship Between Intracranial Blood Flow and Peripheral Perfusion in Patients With Craniocerebral Injury
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ClinicalTrials.gov Identifier: NCT06016751 |
Recruitment Status :
Completed
First Posted : August 30, 2023
Last Update Posted : August 30, 2023
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Condition or disease |
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Brain-injury Intracranial; Blood Vessel, Injury |
Study Type : | Observational |
Actual Enrollment : | 30 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | Relationship Between Intracranial Blood Flow and Peripheral Perfusion in Patients With Craniocerebral Injury Assessed by Doppler Ultrasound and Prognostic Assessment |
Actual Study Start Date : | January 1, 2021 |
Actual Primary Completion Date : | January 1, 2022 |
Actual Study Completion Date : | January 1, 2022 |
Group/Cohort |
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cranial damage
Our study was a prospective observational study which included only a group of patients who were diagnosed with acute craniocerebral injury.
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- intracranial blood flow [ Time Frame: Day 1,Day 3,Day 5 ]Mean intracranial middle cerebral artery blood flow velocity and pulsatility index measured using ultrasound Doppler in enrolled patients.
- Paroxysmal sympathetic excitation [ Time Frame: Day 1,Day 3,Day 5 ]Use of the Paroxysmal Sympathetic Nerve Score to assess paroxysmal sympathoexcitatory performance in patients.
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Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Probability Sample |
Inclusion Criteria:
- Craniocerebral injury patients;
- The middle cerebral artery blood flow spectrum can be clearly displayed with a bedside TCD;
Exclusion Criteria:
- Age Under 18 years;
- history of cardiovascular disease such as coronary artery disease, heart failure, or atrial fibrillation;
- presence of severe valvular disease or ejection fraction (EF) <30%;
- chronic lung disease;
- chronic liver failure or renal insufficiency;
- persons with co-morbidities of malignant neoplasms;
- persons who had co-morbidities with acute and chronic infectious diseases prior to craniocerebral injuries;
- women who were pregnant and breastfeeding;
- history of psychiatric disorders;
- history of drug abuse or alcohol misuse;
- history of β-blockers;
- co-morbidities with spinal cord injuries; and persons who had died or been discharged from hospital within 1 week of hospitalization or who had not been able to obtain a clear image with ultrasonography.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT06016751
China, Beijing | |
Wei Du | |
Beijing, Beijing, China |
Responsible Party: | Peking Union Medical College Hospital |
ClinicalTrials.gov Identifier: | NCT06016751 |
Other Study ID Numbers: |
YLong |
First Posted: | August 30, 2023 Key Record Dates |
Last Update Posted: | August 30, 2023 |
Last Verified: | August 2023 |
Studies a U.S. FDA-regulated Drug Product: | No |
Studies a U.S. FDA-regulated Device Product: | No |
Brain Injuries Craniocerebral Trauma Wounds and Injuries Brain Diseases |
Central Nervous System Diseases Nervous System Diseases Trauma, Nervous System |