Monolaurin Ointment Versus Mupirocin Ointment
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ClinicalTrials.gov Identifier: NCT06046937 |
Recruitment Status :
Completed
First Posted : September 21, 2023
Last Update Posted : October 17, 2023
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Bacterial Infections | Drug: Monolaurin Drug: Mupirocin ointment | Early Phase 1 |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 40 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Double (Participant, Investigator) |
Primary Purpose: | Treatment |
Official Title: | A Randomized, Double-Blind Controlled Trial of Monolaurin Ointment Versus Mupirocin Ointment of Bacterial Skin Infections Among Pediatric Patients 5-18 Years Old in Community-Based Setting |
Actual Study Start Date : | June 1, 2023 |
Actual Primary Completion Date : | June 30, 2023 |
Actual Study Completion Date : | July 15, 2023 |
Arm | Intervention/treatment |
---|---|
Experimental: Monolaurin Ointment
treatment arm
|
Drug: Monolaurin
applied thinly twice a day
Other Name: Treatment Group |
Active Comparator: Mupirocin Ointment
control drug
|
Drug: Mupirocin ointment
applied thinly twice a day
Other Name: Control |
- success or failure of therapy [ Time Frame: 7 days ]clinical success is determined by sufficient resolution of signs and symptoms of infection using Skin Infection Rating Scale (SIRS) Scoring: 0=absent, 1=mild, 2=moderate, 3=severe
- secondary outcome measure 1 [ Time Frame: 7 days ]decrease in wound size in mm
- secondary outcome measure 2 [ Time Frame: 7 days ]post-treatment gram stain and culture result
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Ages Eligible for Study: | 5 Years to 18 Years (Child, Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Subject aged 5 years old to 18 years old (school-aged children)
- Subjects has infected wound (laceration, sutured wound or abrasion), impetigo and other bacterial skin infections (positive gram stain or culture)
- Subject has total skin infection rating scale score of at least 4 including pus/exudate score of at least 1
- Subject parent/legal guardian is willing and able to comply with protocol (see attached consent)
- Subject parent/legal guardian has given written informed consent or assent as applicable.
- Patient has good hygiene
Exclusion Criteria:
- Previous hypersensitivity to Mupirocin
- Secondary- infected animal/human bite or punctured wound
- Subject has a large draining abscess
- Chronic ulcerative lesion
- Other underlying skin disease
- Patient is severely malnourished
- Systemic signs and symptoms of infection
- Infection not to be appropriately treated with topical antibiotic
- Infections requires surgical intervention prior to study
- Subject received systemic antibacterial or steroid, or topical therapeutic agent within 24 hours of entry into study
- Serious underlying medical conditions/ diseases (diabetes mellitus)
- Other investigational drug within 30 days of study entry.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT06046937
Philippines | |
V. Luna Medical Center | |
Quezon City, NCR, Philippines, 1110 |
Study Chair: | Elizabeth Sanchez, MD | V. Luna Medical Center |
Responsible Party: | Wenzyl Jean Etor, Junior Consultant, Victoriano Luna Medical Center |
ClinicalTrials.gov Identifier: | NCT06046937 |
Other Study ID Numbers: |
033/06-20 |
First Posted: | September 21, 2023 Key Record Dates |
Last Update Posted: | October 17, 2023 |
Last Verified: | October 2023 |
Studies a U.S. FDA-regulated Drug Product: | No |
Studies a U.S. FDA-regulated Device Product: | No |
Infections Bacterial Infections Bacterial Infections and Mycoses Mupirocin Monolaurin Anti-Bacterial Agents Anti-Infective Agents |
Protein Synthesis Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Cariostatic Agents Protective Agents Physiological Effects of Drugs |