ClinicalTrials.gov

History of Changes for Study: NCT01287741
A Study of Obinutuzumab (RO5072759) in Combination With CHOP Chemotherapy Versus MabThera/Rituxan (Rituximab) With CHOP in Patients With CD20-Positive Diffuse Large B-Cell Lymphoma (GOYA)
Latest version (submitted April 8, 2019) on ClinicalTrials.gov
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Study Record Versions
Version A B Submitted Date Changes
1 January 31, 2011 None (earliest Version on record)
2 February 15, 2011 Study Status
3 March 15, 2011 Study Status
4 April 18, 2011 Study Status and Contacts/Locations
5 May 18, 2011 Contacts/Locations, Study Status and Oversight
6 June 15, 2011 Contacts/Locations and Study Status
7 July 19, 2011 Contacts/Locations and Study Status
8 August 10, 2011 Recruitment Status, Contacts/Locations and Study Status
9 September 19, 2011 Contacts/Locations and Study Status
10 October 14, 2011 Contacts/Locations and Study Status
11 November 15, 2011 Contacts/Locations and Study Status
12 December 5, 2011 Study Status and Contacts/Locations
13 January 17, 2012 Contacts/Locations, Study Status and Study Design
14 February 15, 2012 Contacts/Locations, Study Status and Study Design
15 February 16, 2012 Eligibility and Study Status
16 March 16, 2012 Contacts/Locations and Study Status
17 March 22, 2012 Contacts/Locations and Study Status
18 April 18, 2012 Contacts/Locations and Study Status
19 May 3, 2012 Study Status, Contacts/Locations, Eligibility, Study Description and Study Identification
20 May 21, 2012 Contacts/Locations and Study Status
21 June 4, 2012 Contacts/Locations, Study Status, Eligibility, Sponsor/Collaborators and Study Identification
22 July 5, 2012 Contacts/Locations, Study Status and Sponsor/Collaborators
23 July 17, 2012 Contacts/Locations and Study Status
24 August 15, 2012 Contacts/Locations and Study Status
25 September 19, 2012 Contacts/Locations and Study Status
26 October 10, 2012 Contacts/Locations and Study Status
27 November 1, 2012 Contacts/Locations and Study Status
28 November 15, 2012 Contacts/Locations and Study Status
29 December 3, 2012 Contacts/Locations and Study Status
30 January 3, 2013 Contacts/Locations and Study Status
31 January 7, 2013 Contacts/Locations and Study Status
32 January 14, 2013 Contacts/Locations and Study Status
33 January 21, 2013 Contacts/Locations and Study Status
34 January 31, 2013 Contacts/Locations and Study Status
35 February 4, 2013 Contacts/Locations and Study Status
36 February 11, 2013 Contacts/Locations and Study Status
37 February 19, 2013 Contacts/Locations and Study Status
38 February 25, 2013 Contacts/Locations and Study Status
39 March 4, 2013 Contacts/Locations and Study Status
40 March 11, 2013 Contacts/Locations and Study Status
41 March 18, 2013 Contacts/Locations and Study Status
42 March 25, 2013 Contacts/Locations and Study Status
43 April 1, 2013 Contacts/Locations and Study Status
44 April 8, 2013 Contacts/Locations and Study Status
45 April 15, 2013 Contacts/Locations and Study Status
46 April 22, 2013 Contacts/Locations and Study Status
47 April 29, 2013 Contacts/Locations and Study Status
48 May 7, 2013 Contacts/Locations and Study Status
49 May 13, 2013 Contacts/Locations and Study Status
50 July 1, 2013 Contacts/Locations and Study Status
51 July 9, 2013 Contacts/Locations and Study Status
52 July 16, 2013 Contacts/Locations and Study Status
53 July 23, 2013 Contacts/Locations and Study Status
54 July 29, 2013 Contacts/Locations and Study Status
55 August 5, 2013 Contacts/Locations and Study Status
56 August 13, 2013 Contacts/Locations and Study Status
57 August 19, 2013 Contacts/Locations and Study Status
58 August 26, 2013 Contacts/Locations and Study Status
59 September 4, 2013 Study Status and Contacts/Locations
60 September 9, 2013 Contacts/Locations and Study Status
61 September 12, 2013 Contacts/Locations and Study Status
62 September 18, 2013 Contacts/Locations and Study Status
63 September 25, 2013 Contacts/Locations and Study Status
64 October 7, 2013 Study Status and Contacts/Locations
65 October 8, 2013 Contacts/Locations and Study Status
66 October 17, 2013 Contacts/Locations and Study Status
67 October 21, 2013 Contacts/Locations and Study Status
68 October 28, 2013 Contacts/Locations and Study Status
69 November 4, 2013 Contacts/Locations and Study Status
70 November 13, 2013 Contacts/Locations and Study Status
71 November 18, 2013 Contacts/Locations and Study Status
72 November 25, 2013 Contacts/Locations and Study Status
73 December 3, 2013 Contacts/Locations and Study Status
74 December 9, 2013 Contacts/Locations and Study Status
75 December 17, 2013 Contacts/Locations and Study Status
76 January 6, 2014 Contacts/Locations and Study Status
77 January 13, 2014 Contacts/Locations and Study Status
78 January 20, 2014 Contacts/Locations, Arms and Interventions, Sponsor/Collaborators and Study Status
79 January 27, 2014 Contacts/Locations and Study Status
80 February 3, 2014 Contacts/Locations and Study Status
81 February 10, 2014 Contacts/Locations and Study Status
82 February 17, 2014 Contacts/Locations, Sponsor/Collaborators and Study Status
83 February 24, 2014 Contacts/Locations and Study Status
84 March 3, 2014 Contacts/Locations and Study Status
85 March 14, 2014 Contacts/Locations and Study Status
86 March 17, 2014 Contacts/Locations and Study Status
87 March 24, 2014 Contacts/Locations and Study Status
88 March 31, 2014 Contacts/Locations and Study Status
89 April 7, 2014 Study Status and Contacts/Locations
90 April 14, 2014 Contacts/Locations and Study Status
91 April 22, 2014 Contacts/Locations and Study Status
92 April 28, 2014 Contacts/Locations and Study Status
93 May 5, 2014 Study Status and Contacts/Locations
94 May 12, 2014 Contacts/Locations and Study Status
95 May 19, 2014 Contacts/Locations and Study Status
96 May 26, 2014 Contacts/Locations and Study Status
97 June 23, 2014 Contacts/Locations, Study Status and Study Description
98 June 30, 2014 Contacts/Locations and Study Status
99 July 7, 2014 Study Status and Contacts/Locations
100 July 14, 2014 Contacts/Locations and Study Status
101 July 21, 2014 Contacts/Locations and Study Status
102 August 4, 2014 Recruitment Status, Study Status, Contacts/Locations and Study Design
103 August 11, 2014 Study Status
104 August 26, 2014 Arms and Interventions and Study Status
105 September 22, 2014 Study Status
106 October 6, 2014 Study Status
107 October 13, 2014 Study Status
108 October 20, 2014 Study Status
109 November 3, 2014 Contacts/Locations and Study Status
110 November 10, 2014 Contacts/Locations and Study Status
111 November 17, 2014 Study Status
112 November 24, 2014 Contacts/Locations and Study Status
113 December 1, 2014 Study Status
114 December 8, 2014 Contacts/Locations and Study Status
115 December 15, 2014 Contacts/Locations and Study Status
116 December 23, 2014 Contacts/Locations and Study Status
117 January 6, 2015 Study Status
118 January 12, 2015 Contacts/Locations, Study Description and Study Status
119 January 19, 2015 Contacts/Locations, Study Description and Study Status
120 February 5, 2015 Study Status, Contacts/Locations and Study Description
121 February 19, 2015 Study Status
122 February 23, 2015 Study Status
123 March 2, 2015 Study Status
124 March 9, 2015 Contacts/Locations and Study Status
125 March 16, 2015 Study Status
126 April 2, 2015 Contacts/Locations and Study Status
127 May 5, 2015 Study Status
128 May 11, 2015 Contacts/Locations and Study Status
129 May 29, 2015 Study Status
130 June 1, 2015 Study Status
131 July 1, 2015 Study Status
132 July 31, 2015 Contacts/Locations and Study Status
133 August 17, 2015 Study Status
134 October 20, 2016 Arms and Interventions, Outcome Measures, Contacts/Locations, Study Status, Study Identification, Eligibility, Conditions and Study Description
135 August 15, 2017 Study Status, Contacts/Locations, Outcome Measures, Arms and Interventions, Results and Eligibility
136 November 9, 2017 Study Status and Contacts/Locations
137 February 20, 2018 Recruitment Status, Contacts/Locations and Study Status
138 April 24, 2018 Contacts/Locations and Study Status
139 May 9, 2018 Study Status and Contacts/Locations
140 July 30, 2018 Contacts/Locations and Study Status
141 April 8, 2019 Recruitment Status, Outcome Measures, Adverse Events, Study Status, Participant Flow, Baseline Characteristics and Contacts/Locations
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Study NCT01287741
Submitted Date:  March 2, 2015 (v123)

Open or close this module Study Identification
Unique Protocol ID: BO21005
Brief Title: A Study of Obinutuzumab (RO5072759) in Combination With CHOP Chemotherapy Versus MabThera/Rituxan (Rituximab) With CHOP in Patients With CD20-Positive Diffuse Large B-Cell Lymphoma (GOYA)
Official Title: A Phase III, Multicenter, Open-label Randomized Trial Comparing the Efficacy of GA101 (RO5072759) in Combination With CHOP (G-CHOP) Versus Rituximab and CHOP (R-CHOP) in Previously Untreated Patients With CD20-positive Diffuse Large B-cell Lymphoma (DLBCL)
Secondary IDs: 2010-024194-39
Open or close this module Study Status
Record Verification: March 2015
Overall Status: Active, not recruiting
Study Start: July 2011
Primary Completion: August 2015 [Anticipated]
Study Completion: May 2016 [Anticipated]
First Submitted: January 31, 2011
First Submitted that
Met QC Criteria:
January 31, 2011
First Posted: February 1, 2011 [Estimate]
Last Update Submitted that
Met QC Criteria:
March 2, 2015
Last Update Posted: March 3, 2015 [Estimate]
Open or close this module Sponsor/Collaborators
Sponsor: Hoffmann-La Roche
Responsible Party: Sponsor
Collaborators: Fondazione Italiana Linfomi - ETS
Open or close this module Oversight
U.S. FDA-regulated Drug:
U.S. FDA-regulated Device:
Data Monitoring:
Open or close this module Study Description
Brief Summary: This open-label, randomized, parallel group study will evaluate the efficacy and safety of obinutuzumab (RO5072759) in combination with CHOP chemotherapy versus MabThera/Rituxan (rituximab) with CHOP in previously untreated patients with CD20-positive diffuse large B-cell lymphoma. Patients will be randomized to receive either obinutuzumab 1000 mg intravenously (iv) every 21 days or MabThera/Rituxan 375 mg/m2 iv every 21 days for 8 cycles, in addition to 6-8 cycles of CHOP chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisolone) iv every 21 days. Anticipated time on study treatment is 24 weeks.
Detailed Description:
Open or close this module Conditions
Conditions: Lymphoma, B-Cell
Keywords:
Open or close this module Study Design
Study Type: Interventional
Primary Purpose: Treatment
Study Phase: Phase 3
Interventional Study Model: Parallel Assignment
Number of Arms: 2
Masking: None (Open Label)
Allocation: Randomized
Enrollment: 1418 [Actual]
Open or close this module Arms and Interventions
Arms Assigned Interventions
Experimental: G-CHOP Drug: CHOP chemotherapy
CHOP chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisolone) iv every 21 days, 6 or 8 cycles
Drug: RO5072759
1000 mg iv every 21 days, 8 cycles (additional doses Days 8 and 15 of Cycle 1)
Other Names:
  • GA101
Active Comparator: R-CHOP Drug: CHOP chemotherapy
CHOP chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisolone) iv every 21 days, 6 or 8 cycles
Drug: rituximab [MabThera/Rituxan]
375 mg/m2 iv every 21 days, 8 cycles
Open or close this module Outcome Measures
Primary Outcome Measures:
1. Progression-free survival, assessed by the investigator according to a modified version of the Revised Response Criteria for Malignant Lymphoma
[ Time Frame: up to approximately 78 months ]

Secondary Outcome Measures:
1. Overall survival
[ Time Frame: up to approximately 78 months ]

2. Overall response rate at the end of treatment, assessed by the investigator and the Independent Review Committee (IRC)
[ Time Frame: 24 weeks ]

3. Complete response rate at the end of treatment, assessed by investigator and IRC
[ Time Frame: 24 weeks ]

4. Progression-free survival assessed by the Independent Review Committee
[ Time Frame: up to approximately 78 months ]

5. Event-free survival, defined as time to progression or relapse, or initiation of non-protocol-specified anti-lymphoma therapy, or death, whichever occurs first
[ Time Frame: up to approximately 78 months ]

6. Disease-free survival, assessed by investigator
[ Time Frame: up to approximately 78 months ]

7. Duration of response, assessed by the investigator
[ Time Frame: up to approximately 78 months ]

8. Time to next lymphoma treatment
[ Time Frame: up to approximately 78 months ]

9. Safety: Incidence of adverse events
[ Time Frame: up to approximately 78 months ]

10. Quality of life (Functional Assessment of Cancer Therapy-Lymphoma subscale, Euro-Quality of Life 5D questionnaire, European Organization for Research and Treatment of Cancer Quality of Life Core 30)
[ Time Frame: up to approximately 78 months ]

11. Medical resource utilization (hospitalizations, drug therapies, medical and surgical procedures and treatments)
[ Time Frame: up to approximately 78 months ]

Open or close this module Eligibility
Minimum Age: 18 Years
Maximum Age:
Sex: All
Gender Based:
Accepts Healthy Volunteers: No
Criteria:

Inclusion Criteria:

  • Adult patients, >/= 18 years of age
  • Previously untreated CD20-positive diffuse large B-cell lymphoma (DLBCL)
  • At least 1 bi-dimensionally measurable lesion (>1.5 cm in is largest dimension on the CT scan)
  • Eastern Cooperative Oncology Group (ECOG) performance status 0, 1 or 2
  • Adequate hematological function
  • Low-intermediate, intermediate or high-risk IPI score (low-risk IPI score: IPI 1 irrespective of bulky disease or IPI 0 with bulky disease, defined as one lesion >/= 7.5 cm)

Exclusion Criteria:

  • History of severe allergic or anaphylactic reactions to humanized or murine monoclonal antibodies or known sensitivity or allergy to murine products
  • Contraindication to any of the individual components of CHOP, including prior receipt of anthracyclines
  • Patients with transformed lymphoma and patients with follicular lymphoma IIIB
  • Prior therapy for DLBCL, with the exception of nodal biopsy or local irradiation
  • Prior treatment with cytotoxic drugs or rituximab for another condition (e.g., rheumatoid arthritis) or prior use of an anti-CD20 antibody
  • Prior use of any monoclonal antibody within 3 months of the start of Cycle 1
  • Ongoing corticosteroid use of > 30 mg/day of prednisone or equivalent
  • Primary CNS lymphoma, blastic variant of mantle-cell lymphoma, or histologic evidence of transformation to a Burkitt lymphoma, primary mediastinal DLBCL, primary effusion lymphoma, and primary cutaneous DLBCL
  • Positive for HIV
  • Active hepatitis B or C infection
Open or close this module Contacts/Locations
Study Officials: Clinical Trials
Study Director
Hoffmann-La Roche
Locations: United States, Alabama
Birmingham, Alabama, United States, 35291-3300
United States, Arizona
Chandler, Arizona, United States, 85224
Tucson, Arizona, United States, 85704
United States, California
Encinitas, California, United States, 92008
Encinitas, California, United States, 92024
Los Angeles, California, United States, 90095-6984
United States, Colorado
Aurora, Colorado, United States, 80012
United States, Florida
Fort Myers, Florida, United States, 33916
St Petersburg, Florida, United States, 33719
United States, Georgia
Macon, Georgia, United States, 31201
United States, Illinois
Galesburg, Illinois, United States, 61401
Joliet, Illinois, United States, 60435
Niles, Illinois, United States, 60714
Urbana, Illinois, United States, 61801
United States, Maine
Portland, Maine, United States, 04102
United States, Minnesota
Saint Louis Park, Minnesota, United States, 55426
Woodbury, Minnesota, United States, 55125
United States, New York
Albany, New York, United States, 12206
United States, North Carolina
Charlotte, North Carolina, United States, 28204
Winston-Salem, North Carolina, United States, 27103
United States, Ohio
Middletown, Ohio, United States, 45042
Sandusky, Ohio, United States, 44870
United States, Oregon
Springfield, Oregon, United States, 97477
United States, South Carolina
Charleston, South Carolina, United States, 29524
Columbia, South Carolina, United States, 29210
United States, Tennessee
Chattanooga, Tennessee, United States, 37404
Nashville, Tennessee, United States, 37203
United States, Texas
Amarillo, Texas, United States, 79106
Fort Worth, Texas, United States, 76104
Houston, Texas, United States, 77030
New Braunfels, Texas, United States, 78130
United States, Virginia
Blacksburg, Virginia, United States, 24060
Richmond, Virginia, United States, 23230
Winchester, Virginia, United States, 22601
United States, Washington
Tacoma, Washington, United States, 98405
Wenatchee, Washington, United States, 98801
Argentina
Cordoba, Argentina, X5003DCE
Rosario, Argentina, 2000
Rosario, Argentina, S2000DSV
Australia, Queensland
Cairns, Queensland, Australia, 4870
Australia, Victoria
Frankston, Victoria, Australia, 3199
Melbourne, Victoria, Australia, 3168
Australia, Western Australia
Perth, Western Australia, Australia, 6000
Austria
Innsbruck, Austria, 6020
Salzburg, Austria, 5020
Wien, Austria, 1090
Brazil, RS
Porto Alegre, RS, Brazil, 90110-270
Porto Alegre, RS, Brazil, 90610-000
Brazil, SC
Florianopolis, SC, Brazil, 88034-000
Brazil, SP
Sao Paulo, SP, Brazil, 01236-030
Sao Paulo, SP, Brazil, 08270-070
Canada, Alberta
Calgary, Alberta, Canada, T2N 4N2
Edmonton, Alberta, Canada, T6G 1Z2
Canada, British Columbia
Vancouver, British Columbia, Canada, V5Z 4E6
Canada, Nova Scotia
Halifax, Nova Scotia, Canada, B3H 2Y9
Canada, Ontario
Ottawa, Ontario, Canada, K1H 8L6
Toronto, Ontario, Canada, M2K 1E1
Toronto, Ontario, Canada, M5G 2M9
Toronto, Ontario, Canada, M9N 1N8
Canada, Quebec
Montreal, Quebec, Canada, H1T 2M4
Montreal, Quebec, Canada, H2L 4M1
Montreal, Quebec, Canada, H3A 1A1
Montreal, Quebec, Canada, H3T 1E2
Quebec City, Quebec, Canada, G1J 1Z4
Rimouski, Quebec, Canada, G5L 5T1
Canada, Saskatchewan
Saskatoon, Saskatchewan, Canada, S7N 4H4
China
Beijing, China, 100021
Beijing, China, 100034
Beijing, China, 100071
Beijing, China, 100142
Beijing, China, 100730
Beijing, China, 100853
Changchun, China, 130021
Changsha, China, 410006
Fujian, China, 350001
Fuzhou, China, 350014
Guangzhou, China, 510060
Guangzhou, China
Hangzhou, China, 310003
Harbin, China, 150081
Nanchang, China, 330006
Nanjing, China, 210008
Nanjing, China, 210009
Nanning, China, 530021
Shanghai, China, 200025
Shanghai, China, 200032
Shanghai, China, 200433
Shenyang, China, 110001
Suzhou, China, 215004
Tianjin, China, 300060
Wuhan, China, 430022
Wuhan, China, 430023
Xi'an, China, 710038
Colombia
Bogota, Colombia
Floridablanca, Colombia
Czech Republic
Brno, Czech Republic, 625 00
Hradec Kralove, Czech Republic, 500 05
Praha 2, Czech Republic, 128 08
Denmark
København Ø, Denmark, 2100
Roskilde, Denmark, 4000
Århus, Denmark, 8000
Germany
Aachen, Germany, 52074
Berlin, Germany, 10707
Dresden, Germany, 01307
Erlangen, Germany, 91054
Giessen, Germany, 35392
Heidelberg, Germany, 69120
Wuerzburg, Germany, 97080
Hong Kong
Hong Kong, Hong Kong
Hungary
Budapest, Hungary, 1083
Budapest, Hungary, 1097
Budapest, Hungary, 1122
Debrecen, Hungary, 4032
Gyor, Hungary, 9024
Kaposvar, Hungary, 7400
Pecs, Hungary, 7624
Szeged, Hungary, 6720
Italy, Calabria
Reggio Calabria, Calabria, Italy, 89100
Italy, Campania
Napoli, Campania, Italy, 80131
Pagani (Sa), Campania, Italy, 84016
Italy, Emilia-Romagna
Bologna, Emilia-Romagna, Italy, 40138
Reggio Emilia, Emilia-Romagna, Italy, 42100
Italy, Friuli-Venezia Giulia
Udine, Friuli-Venezia Giulia, Italy, 33100
Italy, Lazio
Roma, Lazio, Italy, 00161
Italy, Liguria
Genova, Liguria, Italy, 16132
Italy, Lombardia
Brescia, Lombardia, Italy, 25123
Milano, Lombardia, Italy, 20132
Milano, Lombardia, Italy, 20133
Milano, Lombardia, Italy, 20141
Pavia, Lombardia, Italy, 27100
Italy, Piemonte
Alessandria, Piemonte, Italy, 15100
Ivrea, Piemonte, Italy, 10015
Novara, Piemonte, Italy, 28100
Orbassano, Piemonte, Italy, 10043
Torino, Piemonte, Italy, 10126
Italy, Puglia
Bari, Puglia, Italy, 70124
San Giovanni Rotondo, Puglia, Italy, 71013
Tricase - Le, Puglia, Italy, 73039
Italy, Sicilia
Catania, Sicilia, Italy, 95124
Messina, Sicilia, Italy, 98165
Italy, Toscana
Firenze, Toscana, Italy, 50141
Pisa, Toscana, Italy, 56100
Italy, Umbria
Terni, Umbria, Italy, 05100
Italy, Veneto
Treviso, Veneto, Italy, 31100
Verona, Veneto, Italy, 37130
Vicenza, Veneto, Italy, 36100
Japan
Aichi, Japan, 466-8650
Chiba, Japan, 260-8670
Fukuoka, Japan, 812-8582
Fukuoka, Japan, 830-0011
Gifu, Japan, 501-1194
Hokkaido, Japan, 060-8648
Hyogo, Japan, 650-0047
Iwate, Japan, 020-8505
Kanagawa, Japan, 236-0004
Kyoto, Japan, 606-8507
Niigata, Japan, 951-8566
Okayama, Japan, 710-8602
Osaka, Japan, 545-8586
Osaka, Japan, 565-0871
Osaka, Japan, 589-8511
Shimane, Japan, 693-8501
Tochigi, Japan, 329-0498
Tokyo, Japan, 104-0045
Tokyo, Japan, 105-8470
Tokyo, Japan, 113-8603
Tokyo, Japan, 135-8550
Korea, Republic of
Gyeonggi-do, Korea, Republic of, 410-769
Jeollanam-do, Korea, Republic of, 519-763
Seoul, Korea, Republic of, 110-774
Seoul, Korea, Republic of, 120-752
Seoul, Korea, Republic of, 135-710
Seoul, Korea, Republic of, 137-701
Seoul, Korea, Republic of, 138-736
Mexico
Chihuahua, Mexico, 31000
Monterrey, Mexico, 64460
Oaxaca, Mexico, 68000
Queretaro, Mexico, 7600
Panama
Panama City, Panama, 32400
Peru
Lima, Peru, 18
Lima, Peru, 34
Lima, Peru, Lima 41
Poland
Brzozów, Poland, 36-200
Gdansk, Poland, 80-952
Lodz, Poland, 93-510
Lublin, Poland, 20-081
Warszawa, Poland, 02-781
Wroclaw, Poland, 50-367
Russian Federation
Kazan, Russian Federation, 420029
Moscow, Russian Federation, 115478
Nizhny Novgorod, Russian Federation, 603126
Penza, Russian Federation, 440071
Petrozavodsk, Russian Federation, 185019
St Petersburg, Russian Federation, 191024
Serbia
Belgrade, Serbia, 11000
Novi Sad, Serbia, 21000
Slovakia
Bratislava, Slovakia, 833 10
South Africa
Cape Town, South Africa, 7800
Groenkloof, South Africa, 0181
Johannesburg, South Africa, 2193
Johannesburg, South Africa, 2196
Pretoria, South Africa, 0044
Spain
Barcelona, Spain, 08003
Barcelona, Spain, 08035
Barcelona, Spain, 08036
Barcelona, Spain, 08907
Madrid, Spain, 28034
Pontevedra, Spain, 36002
Sevilla, Spain, 41009
Toledo, Spain, 45004
Spain, Navarra
Pamplona, Navarra, Spain, 31008
Spain, Tarragona
Reus, Tarragona, Spain, 43204
Switzerland
Aarau, Switzerland, 5001
Bellinzona, Switzerland, 6500
Chur, Switzerland, 7000
Zürich, Switzerland, 8091
Taiwan
Taipei, Taiwan, 00112
Taipei, Taiwan, 100
Taipei, Taiwan, 112
Taoyuan, Taiwan, 333
Thailand
Bangkok, Thailand, 10330
Bangkok, Thailand, 10400
Bangkok, Thailand, 10700
Khon Kaen, Thailand, 40002
United Kingdom
Aberdeen, United Kingdom, AB25 2ZN
Birmingham, United Kingdom, B9 5SS
Cambridge, United Kingdom, CB2 0QQ
Leicester, United Kingdom, LE1 5WW
Wolverhampton, United Kingdom, WV10 0QP
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