ClinicalTrials.gov
History of Changes for Study: NCT01493505
TRINOVA-3: A Study of AMG 386 or AMG 386 Placebo in Combination With Paclitaxel and Carboplatin to Treat Ovarian Cancer
Latest version (submitted February 22, 2017) on ClinicalTrials.gov
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Study Record Versions
Version A B Submitted Date Changes
1 December 15, 2011 None (earliest Version on record)
2 January 4, 2012 Study Status and Contacts/Locations
3 January 10, 2012 Contacts/Locations, Study Status and Study Identification
4 January 18, 2012 Contacts/Locations and Study Status
5 April 2, 2012 Study Status and Contacts/Locations
6 April 30, 2012 Contacts/Locations and Study Status
7 May 17, 2012 Study Status and Contacts/Locations
8 May 24, 2012 Contacts/Locations and Study Status
9 June 1, 2012 Sponsor/Collaborators, Study Status and Contacts/Locations
10 June 8, 2012 Sponsor/Collaborators, Contacts/Locations and Study Status
11 June 14, 2012 Contacts/Locations and Study Status
12 July 13, 2012 Sponsor/Collaborators, Contacts/Locations and Study Status
13 July 20, 2012 Contacts/Locations and Study Status
14 August 9, 2012 Study Status
15 September 14, 2012 Contacts/Locations and Study Status
16 October 1, 2012 Contacts/Locations and Study Status
17 October 5, 2012 Contacts/Locations and Study Status
18 November 5, 2012 Study Status and Contacts/Locations
19 November 13, 2012 Contacts/Locations and Study Status
20 January 9, 2013 Contacts/Locations and Study Status
21 January 17, 2013 Contacts/Locations and Study Status
22 February 26, 2013 Study Status and Contacts/Locations
23 March 6, 2013 Study Status and Contacts/Locations
24 March 14, 2013 Contacts/Locations and Study Status
25 May 6, 2013 Contacts/Locations and Study Status
26 May 14, 2013 Contacts/Locations and Study Status
27 May 23, 2013 Contacts/Locations and Study Status
28 May 30, 2013 Contacts/Locations and Study Status
29 June 10, 2013 Study Status and Contacts/Locations
30 June 12, 2013 Study Status
31 June 26, 2013 Contacts/Locations and Study Status
32 August 1, 2013 Study Status and Contacts/Locations
33 August 15, 2013 Contacts/Locations and Study Status
34 August 28, 2013 Contacts/Locations and Study Status
35 September 4, 2013 Study Status and Contacts/Locations
36 September 11, 2013 Contacts/Locations and Study Status
37 September 26, 2013 Contacts/Locations and Study Status
38 October 16, 2013 Study Status and Contacts/Locations
39 October 30, 2013 Contacts/Locations and Study Status
40 November 6, 2013 Study Status and Contacts/Locations
41 November 13, 2013 Contacts/Locations and Study Status
42 November 20, 2013 Contacts/Locations and Study Status
43 January 2, 2014 Contacts/Locations and Study Status
44 January 8, 2014 Contacts/Locations and Study Status
45 January 22, 2014 Contacts/Locations and Study Status
46 February 19, 2014 Contacts/Locations and Study Status
47 June 2, 2014 Recruitment Status, Study Status, Contacts/Locations and Study Design
48 September 19, 2014 Study Status
49 September 8, 2015 Study Status
50 October 12, 2015 Study Status
51 December 3, 2015 Study Status
52 January 12, 2016 Study Status
53 April 6, 2016 Study Status
54 November 14, 2016 Study Status
55 January 5, 2017 Recruitment Status and Study Status
56 January 20, 2017 References and Study Status
57 February 22, 2017 Recruitment Status, Study Status and Arms and Interventions
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Study NCT01493505
Submitted Date:  August 15, 2013 (v33)
Open or close this module Study Identification
Unique Protocol ID: 20101129
Brief Title: TRINOVA-3: A Study of AMG 386 or AMG 386 Placebo in Combination With Paclitaxel and Carboplatin to Treat Ovarian Cancer
Official Title: A Phase 3 Randomized, Double-blind, Placebo-controlled, Multicenter Study of AMG 386 With Paclitaxel and Carboplatin as First-line Treatment of Subjects With FIGO Stage III-IV Epithelial Ovarian, Primary Peritoneal or Fallopian Tube Cancers
Secondary IDs: TRINOVA-3 20101129/ENGOT-ov2
Open or close this module Study Status
Record Verification: August 2013
Overall Status: Recruiting
Study Start: January 2012
Primary Completion: May 2016 [Anticipated]
Study Completion: July 2020 [Anticipated]
First Submitted: September 29, 2011
First Submitted that
Met QC Criteria:		 December 15, 2011
First Posted: December 16, 2011 [Estimate]
Last Update Submitted that
Met QC Criteria:		 August 15, 2013
Last Update Posted: August 19, 2013 [Estimate]
Open or close this module Sponsor/Collaborators
Sponsor: Amgen
Responsible Party: Sponsor
Collaborators:
Open or close this module Oversight
U.S. FDA-regulated Drug:
U.S. FDA-regulated Device:
Data Monitoring:
Open or close this module Study Description
Brief Summary: The purpose of this study is to determine whether AMG 386 or AMG 386 Placebo in combination with Paclitaxel and Carboplatin are effective in the treatment of ovarian cancer.
Detailed Description:
Open or close this module Conditions
Conditions: Fallopian Tube Cancer
Ovarian Cancer
Peritoneal Cancer
Keywords: Primary Peritoneal Cancer
Open or close this module Study Design
Study Type: Interventional
Primary Purpose: Treatment
Study Phase: Phase 3
Interventional Study Model: Parallel Assignment
Number of Arms: 2
Masking: Triple (Participant, Care Provider, Investigator)
Allocation: Randomized
Enrollment: 2000 [Anticipated]
Open or close this module Arms and Interventions
Arms Assigned Interventions
Placebo Comparator: Placebo Drug: Paclitaxel
Paclitaxel 175 mg/m2 3 hour IV Q3W (6 cycles)
Drug: AMG 386 Placebo
AMG 386 Placebo IV QW (until progression or unacceptable toxicity develops)
Drug: Carboplatin
Carboplatin AUC 5 or 6 IV Q3W (6 cycles)
Active Comparator: AMG 386 Drug: AMG 386
AMG 386 15mg/kg IV QW (until progression or unacceptable toxicity develops)
Drug: Paclitaxel
Paclitaxel 175 mg/m2 3 hour IV Q3W (6 cycles)
Drug: Carboplatin
Carboplatin AUC 5 or 6 IV Q3W (6 cycles)
Open or close this module Outcome Measures
Primary Outcome Measures:
1. Progression free survival
[ Time Frame: 3 years ]
Secondary Outcome Measures:
1. Overall survival (OS)
[ Time Frame: 5 years ]
2. Incidence of adverse events and significant laboratory abnormalities
[ Time Frame: 4 years ]
3. Pharmacokinetics of AMG 386 (Cmax and Cmin)
[ Time Frame: 1 year ]

pre-dose weeks 1, 7, 10, 19 and within 10 minutes post dose week 1, 7
4. Incidence of anti-AMG 386 antibody formation
[ Time Frame: 4 years ]

pre-dose weeks 1, 10, 19
5. Patient reported ovarian cancer-specific symptoms and health related quality of life
[ Time Frame: 4 years ]
6. Patient reported status as measured by the EuroQOL (EQ-5D)
[ Time Frame: 4 years ]
7. AMG 386 exposure-response relationships for PFS and OS
[ Time Frame: 4 years ]
8. Correlation of serum biomarkers with measures of response
[ Time Frame: 4 years ]
Open or close this module Eligibility
Minimum Age: 18 Years
Maximum Age:
Sex: Female
Gender Based:
Accepts Healthy Volunteers: No
Criteria:

Inclusion Criteria:

  • Female subjects 18 years of age or older with FIGO Stages III-IV epithelial ovarian, primary peritoneal or fallopian tube cancer with an indication for first-line treatment with paclitaxel and carboplatin x 6 cycles (Subjects with pseudomyxoma, mesothelioma, adenocarcinoma with an unknown primary tumour, carcinosarcoma, sarcoma, mucinous or neuroendocrine histology are excluded
  • Subjects with FIGO Stage IIIA or IIIB disease must have undergone PDS for ovarian, primary peritoneal or fallopian tube cancer within 12 weeks prior to randomization
  • Subjects with FIGO Stage IIIC or IV disease must either:
  • Undergo PDS for epithelial ovarian, primary peritoneal or fallopian tube cancer within 12 weeks prior to randomization or
  • Plan to have IDS following 3 cycles of paclitaxel and carboplatin plus AMG 386 or AMG 386 placebo for biopsy proven epithelial ovarian, primary peritoneal or fallopian tube cancer
  • ECOG performance status of 0 or 1
  • Adequate bone marrow, renal and hepatic function

Exclusion Criteria:

  • Prior use of any anticancer therapy or experimental therapy for epithelial ovarian, primary peritoneal or fallopian tube cancer
  • Previous abdominal and/or pelvic external beam radiotherapy
  • History of central nervous metastasis
  • History of arterial or venous thromboembolism within 12 months prior to randomization
  • Clinically significant cardiovascular disease within 12 months prior to randomization
Open or close this module Contacts/Locations
Central Contact Person: Amgen Call Center
Telephone: 866-572-6436
Study Officials: MD
Study Director
Amgen
Locations: United States, Alabama
Research Site
[Recruiting]
Birmingham, Alabama, United States, 35233
Research Site
[Recruiting]
Mobile, Alabama, United States, 36604
United States, Arizona
Research Site
[Recruiting]
Gilbert, Arizona, United States, 85234
Research Site
[Recruiting]
Peoria, Arizona, United States, 85381
Research Site
[Recruiting]
Phoenix, Arizona, United States, 85013
Research Site
[Recruiting]
Phoenix, Arizona, United States, 85016
Research Site
[Recruiting]
Tucson, Arizona, United States, 85704
Research Site
[Recruiting]
Tucson, Arizona, United States, 85710
United States, California
Research Site
[Recruiting]
Berkeley, California, United States, 94704
Research Site
[Completed]
Berkeley, California, United States, 94704
Research Site
[Recruiting]
Burbank, California, United States, 91505
Research Site
[Recruiting]
Concord, California, United States, 94520
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[Recruiting]
Corona, California, United States, 92879
Research Site
[Recruiting]
La Jolla, California, United States, 92093-0957
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[Recruiting]
Long Beach, California, United States, 90806
Research Site
[Recruiting]
Los Angeles, California, United States, 90027
Research Site
[Recruiting]
Orange, California, United States, 92868
Research Site
[Recruiting]
Oxnard, California, United States, 93030
Research Site
[Recruiting]
Rancho Mirage, California, United States, 92270
Research Site
[Recruiting]
Sacramento, California, United States, 95816
United States, Colorado
Research Site
[Recruiting]
Aurora, Colorado, United States, 80045
Research Site
[Recruiting]
Englewood, Colorado, United States, 80113
United States, Connecticut
Research Site
[Recruiting]
Bridgeport, Connecticut, United States, 06606
Research Site
[Recruiting]
Hartford, Connecticut, United States, 06106
Research Site
[Recruiting]
New Britain, Connecticut, United States, 06050
Research Site
[Recruiting]
Stamford, Connecticut, United States, 06902
United States, Florida
Research Site
[Recruiting]
Clearwater, Florida, United States, 33756
Research Site
[Recruiting]
Miami, Florida, United States, 33146
Research Site
[Recruiting]
Orlando, Florida, United States, 32804
Research Site
[Recruiting]
Orlando, Florida, United States, 32806
Research Site
[Recruiting]
St Petersburg, Florida, United States, 33701
Research Site
[Recruiting]
Sunrise, Florida, United States, 33323
United States, Georgia
Research Site
[Recruiting]
Augusta, Georgia, United States, 30912
Research Site
[Recruiting]
Gainesville, Georgia, United States, 30501
Research Site
[Recruiting]
Macon, Georgia, United States, 31201
Research Site
[Completed]
Macon, Georgia, United States, 31201
United States, Hawaii
Research Site
[Recruiting]
Honolulu, Hawaii, United States, 96826
United States, Illinois
Research Site
[Recruiting]
Chicago, Illinois, United States, 60637
Research Site
[Recruiting]
Hinsdale, Illinois, United States, 60521
Research Site
[Recruiting]
Maywood, Illinois, United States, 60153
Research Site
[Recruiting]
Urbana, Illinois, United States, 61801
United States, Indiana
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[Recruiting]
Indianapolis, Indiana, United States, 46202
Research Site
[Recruiting]
Indianapolis, Indiana, United States, 46237
Research Site
[Recruiting]
South Bend, Indiana, United States, 46601
United States, Iowa
Research Site
[Recruiting]
Ames, Iowa, United States, 50010
United States, Kansas
Research Site
[Recruiting]
Kansas City, Kansas, United States, 66160
United States, Kentucky
Research Site
[Recruiting]
Lexington, Kentucky, United States, 40536
United States, Louisiana
Research Site
[Recruiting]
Covington, Louisiana, United States, 70433
United States, Maine
Research Site
[Recruiting]
Scarborough, Maine, United States, 04074
United States, Maryland
Research Site
[Recruiting]
Baltimore, Maryland, United States, 21204
Research Site
[Recruiting]
Baltimore, Maryland, United States, 21215
Research Site
[Recruiting]
Baltimore, Maryland, United States, 21237
United States, Michigan
Research Site
[Recruiting]
Detroit, Michigan, United States, 48202
Research Site
[Recruiting]
Kalamazoo, Michigan, United States, 49007
United States, Minnesota
Research Site
[Recruiting]
St. Louis Park, Minnesota, United States, 55426
Research Site
[Completed]
St. Louis Park, Minnesota, United States, 55426
United States, Mississippi
Research Site
[Recruiting]
Jackson, Mississippi, United States, 39216
United States, Missouri
Research Site
[Recruiting]
Kansas City, Missouri, United States, 64111
United States, Montana
Research Site
[Recruiting]
Billings, Montana, United States, 59101
United States, Nevada
Research Site
[Recruiting]
Las Vegas, Nevada, United States, 89169
Research Site
[Recruiting]
Reno, Nevada, United States, 89502
United States, New Hampshire
Research Site
[Recruiting]
Lebanon, New Hampshire, United States, 03756
United States, New Jersey
Research Site
[Recruiting]
Hackensack, New Jersey, United States, 07601
Research Site
[Recruiting]
Neptune, New Jersey, United States, 07753
Research Site
[Recruiting]
Voorhees, New Jersey, United States, 08043
United States, New Mexico
Research Site
[Recruiting]
Albuquerque, New Mexico, United States, 87102
Research Site
[Recruiting]
Albuquerque, New Mexico, United States, 87131
United States, New York
Research Site
[Recruiting]
Albany, New York, United States, 12208
Research Site
[Recruiting]
Brightwaters, New York, United States, 11718
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[Recruiting]
Lake Success, New York, United States, 11042
Research Site
[Recruiting]
New York, New York, United States, 10029
Research Site
[Recruiting]
New York, New York, United States, 10032
United States, North Carolina
Research Site
[Recruiting]
Asheville, North Carolina, United States, 28806
Research Site
[Recruiting]
Burlington, North Carolina, United States, 27215
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[Recruiting]
Chapel Hill, North Carolina, United States, 27599-7570
Research Site
[Recruiting]
Winston Salem, North Carolina, United States, 27103
Research Site
[Recruiting]
Winston Salem, North Carolina, United States, 27157
United States, Ohio
Research Site
[Recruiting]
Akron, Ohio, United States, 44304
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[Recruiting]
Canton, Ohio, United States, 44710
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[Recruiting]
Cincinnati, Ohio, United States, 45220
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[Recruiting]
Cleveland, Ohio, United States, 44106
Research Site
[Recruiting]
Cleveland, Ohio, United States, 44195
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[Recruiting]
Columbus, Ohio, United States, 43210
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[Recruiting]
Columbus, Ohio, United States, 43214
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[Recruiting]
Kettering, Ohio, United States, 45429
Research Site
[Recruiting]
Mayfield Heights, Ohio, United States, 44124
Research Site
[Recruiting]
Toledo, Ohio, United States, 43614
United States, Oklahoma
Research Site
[Recruiting]
Oklahoma City, Oklahoma, United States, 73104
Research Site
[Recruiting]
Tulsa, Oklahoma, United States, 74136
United States, Oregon
Research Site
[Recruiting]
Bend, Oregon, United States, 97701
United States, Pennsylvania
Research Site
[Recruiting]
Abington, Pennsylvania, United States, 19001
Research Site
[Recruiting]
Bethlehem, Pennsylvania, United States, 18015
Research Site
[Recruiting]
Philadelphia, Pennsylvania, United States, 19104
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[Recruiting]
Philadelphia, Pennsylvania, United States, 19106
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[Recruiting]
Philadelphia, Pennsylvania, United States, 19107
Research Site
[Recruiting]
Pittsburgh, Pennsylvania, United States, 15213
Research Site
[Recruiting]
Pittsburgh, Pennsylvania, United States, 15224
Research Site
[Recruiting]
West Reading, Pennsylvania, United States, 19611
United States, Rhode Island
Research Site
[Recruiting]
Providence, Rhode Island, United States, 02905
United States, South Carolina
Research Site
[Recruiting]
Charleston, South Carolina, United States, 29425
Research Site
[Completed]
Columbia, South Carolina, United States, 29210
Research Site
[Recruiting]
Greenville, South Carolina, United States, 29605
United States, South Dakota
Research Site
[Recruiting]
Sioux Falls, South Dakota, United States, 57105
United States, Tennessee
Research Site
[Recruiting]
Chattanooga, Tennessee, United States, 37403
United States, Texas
Research Site
[Recruiting]
Austin, Texas, United States, 78701
Research Site
[Recruiting]
Austin, Texas, United States, 78731
Research Site
[Recruiting]
Bedford, Texas, United States, 76022
Research Site
[Recruiting]
Dallas, Texas, United States, 75231
Research Site
[Recruiting]
Dallas, Texas, United States, 75246
Research Site
[Recruiting]
Galveston, Texas, United States, 77555
Research Site
[Recruiting]
Houston, Texas, United States, 77030
Research Site
[Recruiting]
San Antonio, Texas, United States, 78217
Research Site
[Recruiting]
The Woodlands, Texas, United States, 77380
United States, Utah
Research Site
[Recruiting]
Ogden, Utah, United States, 84403
United States, Vermont
Research Site
[Recruiting]
Burlington, Vermont, United States, 05401
United States, Virginia
Research Site
[Recruiting]
Annandale, Virginia, United States, 22003
Research Site
[Recruiting]
Norfolk, Virginia, United States, 23502
Research Site
[Recruiting]
Winchester, Virginia, United States, 22601
Research Site
[Recruiting]
Woodbridge, Virginia, United States, 22191
United States, Washington
Research Site
[Recruiting]
Seattle, Washington, United States, 98104
Research Site
[Recruiting]
Wenatchee, Washington, United States, 98801
United States, Wisconsin
Research Site
[Recruiting]
Green Bay, Wisconsin, United States, 54301
Research Site
[Recruiting]
Green Bay, Wisconsin, United States, 54311
Research Site
[Recruiting]
Milwaukee, Wisconsin, United States, 53215
Research Site
[Recruiting]
Milwaukee, Wisconsin, United States, 53226
Research Site
[Recruiting]
Milwaukee, Wisconsin, United States, 53233
Research Site
[Recruiting]
Oshkosh, Wisconsin, United States, 54904
Research Site
[Recruiting]
Sheboygan, Wisconsin, United States, 53081
Research Site
[Recruiting]
Wausau, Wisconsin, United States, 54401
Research Site
[Recruiting]
West Allis, Wisconsin, United States, 53227
Austria
Research Site
[Recruiting]
Graz, Austria, 8020
Research Site
[Recruiting]
Graz, Austria, 8036
Research Site
[Recruiting]
Innsbruck, Austria, 6020
Research Site
[Recruiting]
Linz, Austria, 4010
Research Site
[Completed]
Linz, Austria, 4010
Research Site
[Recruiting]
Linz, Austria, 4020
Research Site
[Recruiting]
Salzburg, Austria, 5020
Research Site
[Recruiting]
Wien, Austria, 1130
Belgium
Research Site
[Recruiting]
Bonheiden, Belgium, 2820
Research Site
[Recruiting]
Brasschaat, Belgium, 2930
Research Site
[Recruiting]
Charleroi, Belgium, 6000
Research Site
[Recruiting]
Duffel, Belgium, 2570
Research Site
[Recruiting]
Edegem, Belgium, 2650
Research Site
[Recruiting]
Gent, Belgium, 9000
Research Site
[Recruiting]
Hasselt, Belgium, 3500
Research Site
[Recruiting]
Kortrijk, Belgium, 8500
Research Site
[Recruiting]
Leuven, Belgium, 3000
Research Site
[Recruiting]
Libramont, Belgium, 6800
Research Site
[Recruiting]
Liège, Belgium, 4000
Research Site
[Recruiting]
Namur, Belgium, 5000
Research Site
[Recruiting]
Oostende, Belgium, 8400
Research Site
[Recruiting]
Sint-Niklaas, Belgium, 9100
Research Site
[Recruiting]
Turnhout, Belgium, 2300
Research Site
[Recruiting]
Wilrijk, Belgium, 2610
Research Site
[Recruiting]
Yvoir, Belgium, 5530
Canada
Research Site
[Recruiting]
Quebec, Canada, G1R 2J6
Canada, Alberta
Research Site
[Recruiting]
Calgary, Alberta, Canada, T2N 4N2
Research Site
[Recruiting]
Edmonton, Alberta, Canada, T6G 1Z2
Canada, Nova Scotia
Research Site
[Recruiting]
Halifax, Nova Scotia, Canada, B3H 1V7
Canada, Ontario
Research Site
[Recruiting]
Kingston, Ontario, Canada, K7L 5P9
Research Site
[Completed]
Kingston, Ontario, Canada, K7L 5P9
Research Site
[Recruiting]
London, Ontario, Canada, N6A 4L6
Research Site
[Recruiting]
Sault Ste. Marie, Ontario, Canada, P6B 0A8
Research Site
[Recruiting]
Toronto, Ontario, Canada, M4N 3M5
Research Site
[Recruiting]
Toronto, Ontario, Canada, M5G 2M9
Canada, Quebec
Research Site
[Recruiting]
Montreal, Quebec, Canada, H2L 4M1
Denmark
Research Site
[Recruiting]
Herlev, Denmark, 2730
Research Site
[Recruiting]
København Ø, Denmark, 2100
Research Site
[Completed]
Roskilde, Denmark, 4000
Germany
Research Site
[Recruiting]
Berlin, Germany, 13353
Research Site
[Recruiting]
Dresden, Germany, 01307
Research Site
[Recruiting]
Düsseldorf, Germany, 40217
Research Site
[Recruiting]
Düsseldorf, Germany, 40225
Research Site
[Recruiting]
Erlangen, Germany, 91054
Research Site
[Recruiting]
Essen, Germany, 45136
Research Site
[Recruiting]
Essen, Germany, 45147
Research Site
[Recruiting]
Frankfurt, Germany, 65929
Research Site
[Recruiting]
Frankfurt am Main, Germany, 60590
Research Site
[Recruiting]
Freiburg, Germany, 79106
Research Site
[Recruiting]
Hamburg, Germany, 20246
Research Site
[Recruiting]
Hannover, Germany, 30177
Research Site
[Recruiting]
Hannover, Germany, 30625
Research Site
[Recruiting]
Kiel, Germany, 24105
Research Site
[Recruiting]
Konstanz, Germany, 78464
Research Site
[Recruiting]
Ludwigsburg, Germany, 71640
Research Site
[Recruiting]
München, Germany, 80337
Research Site
[Recruiting]
München, Germany, 81377
Research Site
[Recruiting]
München, Germany, 81675
Research Site
[Recruiting]
Oldenburg, Germany, 26121
Research Site
[Recruiting]
Ravensburg, Germany, 88212
Research Site
[Recruiting]
Rostock, Germany, 18059
Research Site
[Recruiting]
Stuttgart, Germany, 70374
Research Site
[Recruiting]
Tübingen, Germany, 72076
Research Site
[Recruiting]
Ulm, Germany, 89075
Greece
Research Site
[Recruiting]
Athens, Greece, 11527
Research Site
[Recruiting]
Athens, Greece, 11528
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[Recruiting]
Athens, Greece, 14564
Research Site
[Recruiting]
Thessaloniki, Greece, 56429
Hong Kong
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[Recruiting]
Hong Kong, Hong Kong
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[Recruiting]
Kowloon, Hong Kong
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[Recruiting]
New Territories, Hong Kong
Italy
Research Site
[Recruiting]
Avellino, Italy, 83100
Research Site
[Recruiting]
Aviano PN, Italy, 33081
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[Recruiting]
Bari, Italy, 70124
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[Recruiting]
Bologna, Italy, 40138
Research Site
[Recruiting]
Brescia, Italy, 25123
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[Recruiting]
Genova, Italy, 16132
Research Site
[Recruiting]
Milano, Italy, 20133
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[Recruiting]
Milano, Italy, 20141
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[Recruiting]
Napoli, Italy, 80131
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[Recruiting]
Novara, Italy, 28100
Research Site
[Recruiting]
Palermo, Italy, 90126
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[Recruiting]
Pisa, Italy, 56126
Research Site
[Recruiting]
Roma, Italy, 00144
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[Recruiting]
Roma, Italy, 00168
Research Site
[Recruiting]
Torino, Italy, 10126
Japan
Research Site
[Recruiting]
Tokyo, Japan, 105-8471
Research Site
[Recruiting]
Tokyo, Japan, 160-8582
Japan, Aichi
Research Site
[Recruiting]
Nagoya-city, Aichi, Japan, 464-8681
Japan, Chiba
Research Site
[Recruiting]
Kashiwa, Chiba, Japan, 277-8567
Japan, Fukuoka
Research Site
[Recruiting]
Fukuoka-shi, Fukuoka, Japan, 811-1395
Research Site
[Recruiting]
Kurume-city, Fukuoka, Japan, 830-0011
Japan, Hiroshima
Research Site
[Recruiting]
Kure-city, Hiroshima, Japan, 737-0023
Japan, Hokkaido
Research Site
[Recruiting]
Sapporo-city, Hokkaido, Japan, 003-0804
Japan, Iwate
Research Site
[Recruiting]
Morioka-city, Iwate, Japan, 020-8505
Japan, Saitama
Research Site
[Recruiting]
Kitaadachi-gun, Saitama, Japan, 362-0806
Japan, Shizuoka
Research Site
[Recruiting]
Suntou-gun, Shizuoka, Japan, 411-8777
Japan, Tottori
Research Site
[Recruiting]
Yonago-city, Tottori, Japan, 683-8504
Korea, Republic of
Research Site
[Recruiting]
Goyang-si, Gyeonggi-do, Korea, Republic of, 410-769
Research Site
[Recruiting]
Seoul, Korea, Republic of, 110-744
Research Site
[Recruiting]
Seoul, Korea, Republic of, 135-710
Research Site
[Recruiting]
Seoul, Korea, Republic of, 138-736
Netherlands
Research Site
[Recruiting]
Deventer, Netherlands, 7416 SE
Research Site
[Recruiting]
Leiden, Netherlands, 2333 ZA
Research Site
[Recruiting]
Nijmegen, Netherlands, 6525 GA
Research Site
[Recruiting]
Rotterdam, Netherlands, 3015 CE
Russian Federation
Research Site
[Recruiting]
Chelyabinsk, Russian Federation, 454087
Research Site
[Recruiting]
Ivanovo, Russian Federation, 153013
Research Site
[Recruiting]
Krasnodar, Russian Federation, 350040
Research Site
[Recruiting]
Moscow, Russian Federation, 115478
Research Site
[Recruiting]
Obninsk, Russian Federation, 249036
Research Site
[Recruiting]
Pyatigorsk, Russian Federation, 357502
Research Site
[Recruiting]
Saint Petersburg, Russian Federation, 197022
Research Site
[Recruiting]
Ufa, Russian Federation, 450054
Research Site
[Recruiting]
Voronezh, Russian Federation, 394000
Spain
Research Site
[Recruiting]
Madrid, Spain, 28009
Research Site
[Recruiting]
Madrid, Spain, 28033
Research Site
[Recruiting]
Madrid, Spain, 28034
Research Site
[Recruiting]
Madrid, Spain, 28040
Research Site
[Recruiting]
Madrid, Spain, 28041
Research Site
[Recruiting]
Madrid, Spain, 28046
Research Site
[Recruiting]
Madrid, Spain, 28050
Spain, Aragón
Research Site
[Recruiting]
Zaragoza, Aragón, Spain, 50009
Spain, Asturias
Research Site
[Recruiting]
Oviedo, Asturias, Spain, 33006
Spain, Baleares
Research Site
[Recruiting]
Palma de Mallorca, Baleares, Spain, 07198
Spain, Cataluña
Research Site
[Recruiting]
Badalona, Cataluña, Spain, 08916
Research Site
[Recruiting]
Barcelona, Cataluña, Spain, 08035
Research Site
[Recruiting]
Lleida, Cataluña, Spain, 25198
Spain, Comunidad Valenciana
Research Site
[Recruiting]
Valencia, Comunidad Valenciana, Spain, 46009
Research Site
[Completed]
Valencia, Comunidad Valenciana, Spain, 46026
Spain, Murcia
Research Site
[Recruiting]
El Palmar, Murcia, Spain, 30120
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Available IPD/Information:
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