Primary Outcome Measures: | |
1. |
The prevalence of challenge-proven food allergy at 12 months of age [ Time Frame: At 12 months of age ]
The prevalence of challenge-proven food allergy at 12 months of age determined by a positive SPT and a positive oral food challenge |
2. |
The occurrence of definite food allergy or tolerance at 6 years of age [ Time Frame: At 6 years of age ]
The occurrence of definite food allergy or tolerance at 6 years of age can only be determined by combining data from an oral food challenge, a skin prick test (SPT) and/or serum specific IgE test, and/or parent/self-reported ingestion history and reactions to the index food. |
Secondary Outcome Measures: | |
1. |
The prevalence of food sensitisation at 12 months of age determined by SPT positive [ Time Frame: At 12 months of age ]
The prevalence of food sensitisation at 12 months of age determined by SPT positive |
2. |
The prevalence of doctor diagnosed eczema during the first postnatal year [ Time Frame: During the first postnatal year ]
The prevalence of doctor diagnosed eczema during the first postnatal year |
3. |
The prevalence of vitamin D insufficiency (serum concentration of 25(OH)D <50 nmol/L ) at age 12 months determined by measuring blood taken at the 12 month clinic visit [ Time Frame: At 12 months of age ]
The prevalence of vitamin D insufficiency (serum concentration of 25(OH)D <50 nmol/L ) at age 12 months determined by measuring blood taken at the 12 month clinic visit |
4. |
Allergy-related healthcare utilisation within the first 12 months of life [ Time Frame: Within the first 12 months of life ]
Allergy-related healthcare utilisation within the first 12 months of life |
5. |
Infection episodes within the first 12 months of life [ Time Frame: Within the first 12 months of life ]
Infection episodes within the first 12 months of life |
6. |
Measure of height at 12 months of age [ Time Frame: At 12 months of age ]
Measure of height at 12 months of age |
7. |
Measure of weight at 12months of age [ Time Frame: At 12 months of age ]
Measure of weight at 12months of age |
8. |
Wheeze episodes within the first 12 months of life [ Time Frame: Within the first 12 months of life ]
Wheeze episodes within the first 12 months of life |
9. |
The occurrence of food sensitisation at 6 years of age determined by SPT positive [ Time Frame: At 6 years of age ]
The occurrence of food sensitisation at 6 years of age determined by SPT positive |
10. |
The occurrence of asthma in the first 6 years of life [ Time Frame: At 6 years of age ]
The occurrence of asthma at 6 years of age |
11. |
The occurrence of eczema in the first 6 years of life [ Time Frame: Within first 6 years of life ]
The occurrence of eczema in the first 6 years of life |
12. |
The prevalence of vitamin D insufficiency (serum concentration of 25(OH)D <50 nmol/L ) at age 6 years determined by measuring blood taken at the 6 year clinic visit [ Time Frame: At 6 years of age ]
The prevalence of vitamin D insufficiency (serum concentration of 25(OH)D <50 nmol/L ) at age 6 years determined by measuring blood taken at the 6 year clinic visit |
13. |
Allergy-related healthcare utilisation in the first 6 years of life [ Time Frame: Within first 6 years of life ]
Allergy-related healthcare utilisation in the first 6 years of life by data linkage from MBS and PBS |
14. |
Measure of height at 6 years of age [ Time Frame: At 6 years of age ]
Measure of height at 6 years of age |
15. |
Measure of Waist circumference at 6 years of age [ Time Frame: At 6 years of age ]
Measure of Waist circumference at 6 years of age |
16. |
Measure of Hip circumference at 6 years of age [ Time Frame: At 6 years of age ]
Measure of Hip circumference at 6 years of age |
17. |
Lung function at 6 years of age [ Time Frame: At 6 years of age ]
Lung function: bronchial responsiveness is measured using the percent change from baseline and absolute changes in forced expiratory volume (FEV) in 1 second and/or forced vital capacity (FVC) at 6 years of age |
18. |
The occurrence of rhinitis in the first 6 years of life [ Time Frame: Within first 6 years of life ]
The occurrence of rhinitis in the first 6 years of life |
19. |
Psychosocial Distress at 6 years of age [ Time Frame: At 6 years of age ]
Psychosocial health at 6 years of age by Kessler Psychological Distress Scale-10 (K-10) for parents The K10 scale involves 10 questions about emotional states each with a five-level response scale. Each item is scored from one 'none of the time' to five 'all of the time'. Scores of the 10 items are then summed, yielding a minimum score of 10 and a maximum score of 50. Low scores indicate low levels of psychological distress and high scores indicate high levels of psychological distress. |
20. |
Psychosocial health at 6 years of age [ Time Frame: At 6 years of age ]
Psychosocial health at 6 years of age by Strengths and Difficulties Questionnaire (SDQ) for child SDQ ask about 25 attributes, some positive and others negative.bThese 25 items are divided between 5 scales:
- emotional symptoms (5 items) } 1) to 4) added together to generate a total difficulties score (based on 20 items)
- conduct problems (5 items)
- hyperactivity/inattention (5 items)
- peer relationship problems (5 items)
- prosocial behaviour (5 items)
|
21. |
Quality of life at 6 years of age [ Time Frame: At 6 years of age ]
Quality of life (QL) at 6 years of age by Child Health Utility 9D (CHU9D, parent proxy version; PedsQL Parent Report for Young Children ages 5-7) The questionnaire has 9 questions with 5 response levels per question. The CHU9D allows the analyst to obtain quality adjusted life years (QALYs) directly for use in cost utility analysis. |
22. |
Quality of life regarding Food Allergy at 6 years of age [ Time Frame: At 6 years of age ]
Quality of life (QL) at 6 years of age by Food Allergy Quality of Life Questionnaires-Parent Form (FAQLQ-PF) All items are scored on a 7-point Likert scale from 0 (not at all troubled) to 6 (extremely troubled) [22]. The total scores are divided by the number of items answered, giving a range of scores from 0 to 6, with higher values indicating a poorer quality of life |
23. |
Cardiovascular health (vascular function) at 6 years of age [ Time Frame: At 6 years of age ]
Cardiovascular health at 6 years of age determined by assessing vascular function through a pulse doppler recording of the blood flow |
24. |
Cardiovascular health (Carotid and aortic Intima-Media Thickness) at 6 years of age [ Time Frame: At 6 years of age ]
Cardiovascular health (Carotid and aortic Intima-Media Thickness) at 6 years of age by acquiring images with simultaneous ECG gating |
25. |
Cardiovascular health (Blood pressure) at 6 years of age [ Time Frame: At 6 years of age ]
Cardiovascular health (Brachial and central blood pressure ) at 6 years of age will be measured using the SphygmoCor® XCEL system. |
26. |
Cardiovascular health (Arterial stiffness) at 6 years of age [ Time Frame: At 6 years of age ]
Cardiovascular health (Arterial stiffness ) at 6 years of age will be assessed by central and peripheral pulse wave velocity (PWV) and pressure waveform analysis (PWA) using a cuff for the femoral artery and tonometer pressure sensor for the carotid artery. |
27. |
Dental health at 6 years of age [ Time Frame: At 6 years of age ]
Dental health at 6 years of age: A registered oral health professional will examine the participant's mouth and teeth, checking for cavities/dental decay as well as developmental mark on the teeth. In addition, a 3D scan and/or photographs of the participant's teeth will be taken to document findings. |
28. |
Hearing health at 6 years of age [ Time Frame: At 6 years of age ]
Hearing health at 6 years of age by using SHOEBOX® Audiometry Professional Edition to measure hearing threshold |