ClinicalTrials.gov
History of Changes for Study: NCT00066703
Triptorelin With Either Exemestane or Tamoxifen in Treating Premenopausal Women With Hormone-Responsive Breast Cancer
Latest version (submitted December 14, 2023) on ClinicalTrials.gov
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Study Record Versions
Version A B Submitted Date Changes
1 June 23, 2005 None (earliest Version on record)
2 July 8, 2005 Study Status
3 August 2, 2005 Contacts/Locations and Study Status
4 August 16, 2005 Contacts/Locations, Study Status and Study Identification
5 August 22, 2005 Contacts/Locations and Study Status
6 August 29, 2005 Contacts/Locations and Study Status
7 September 6, 2005 Contacts/Locations and Study Status
8 September 8, 2005 Study Status
9 September 15, 2005 Contacts/Locations and Study Status
10 September 20, 2005 Contacts/Locations and Study Status
11 September 26, 2005 Contacts/Locations and Study Status
12 October 12, 2005 Contacts/Locations and Study Status
13 October 20, 2005 Contacts/Locations and Study Status
14 October 25, 2005 Contacts/Locations, Arms and Interventions and Study Status
15 November 3, 2005 Contacts/Locations, Conditions and Study Status
16 November 11, 2005 Contacts/Locations and Study Status
17 November 18, 2005 Contacts/Locations and Study Status
18 November 22, 2005 Contacts/Locations and Study Status
19 December 6, 2005 Contacts/Locations and Study Status
20 December 7, 2005 Contacts/Locations and Study Status
21 December 14, 2005 Contacts/Locations and Study Status
22 January 10, 2006 Contacts/Locations and Study Status
23 January 12, 2006 Contacts/Locations, Study Status, Eligibility and Study Description
24 January 16, 2006 Contacts/Locations and Study Status
25 January 24, 2006 Contacts/Locations and Study Status
26 February 6, 2006 Contacts/Locations and Study Status
27 February 9, 2006 Study Status and Contacts/Locations
28 March 8, 2006 Contacts/Locations and Study Status
29 March 9, 2006 Contacts/Locations and Study Status
30 March 15, 2006 Contacts/Locations and Study Status
31 March 21, 2006 Study Status and Study Identification
32 March 29, 2006 Contacts/Locations and Study Status
33 April 11, 2006 Study Status, Contacts/Locations and Eligibility
34 April 19, 2006 Contacts/Locations and Study Status
35 April 24, 2006 Contacts/Locations, Arms and Interventions and Study Status
36 May 10, 2006 Contacts/Locations and Study Status
37 May 16, 2006 Contacts/Locations and Study Status
38 May 30, 2006 Contacts/Locations and Study Status
39 June 7, 2006 Study Status
40 June 8, 2006 Contacts/Locations and Study Status
41 June 13, 2006 Contacts/Locations and Study Status
42 June 22, 2006 Contacts/Locations and Study Status
43 June 28, 2006 Contacts/Locations and Study Status
44 July 5, 2006 Contacts/Locations and Study Status
45 July 13, 2006 Contacts/Locations and Study Status
46 July 19, 2006 Contacts/Locations and Study Status
47 July 26, 2006 Contacts/Locations and Study Status
48 August 3, 2006 Study Status
49 August 10, 2006 Contacts/Locations and Study Status
50 August 16, 2006 Contacts/Locations and Study Status
51 August 24, 2006 Contacts/Locations and Study Status
52 August 29, 2006 Contacts/Locations and Study Status
53 September 6, 2006 Study Status
54 September 13, 2006 Contacts/Locations and Study Status
55 September 19, 2006 Contacts/Locations and Study Status
56 September 26, 2006 Contacts/Locations and Study Status
57 September 29, 2006 Study Status
58 October 12, 2006 Contacts/Locations and Study Status
59 October 18, 2006 Contacts/Locations and Study Status
60 October 25, 2006 Contacts/Locations, Eligibility and Study Status
61 November 8, 2006 Study Design, Conditions, Study Status, References and Study Identification
62 November 9, 2006 Contacts/Locations and Study Status
63 November 16, 2006 Contacts/Locations and Study Status
64 November 27, 2006 Contacts/Locations and Study Status
65 December 6, 2006 Contacts/Locations and Study Status
66 December 20, 2006 Contacts/Locations and Study Status
67 December 27, 2006 Contacts/Locations, Outcome Measures and Study Status
68 January 11, 2007 Study Status
69 January 16, 2007 Contacts/Locations and Study Status
70 January 25, 2007 Contacts/Locations, Study Status and Eligibility
71 January 30, 2007 Contacts/Locations and Study Status
72 February 8, 2007 Contacts/Locations and Study Status
73 February 20, 2007 Contacts/Locations, Study Status and Eligibility
74 March 5, 2007 Contacts/Locations and Study Status
75 March 7, 2007 Contacts/Locations and Study Status
76 March 13, 2007 Contacts/Locations and Study Status
77 March 20, 2007 Contacts/Locations and Study Status
78 March 27, 2007 Contacts/Locations and Study Status
79 April 9, 2007 Contacts/Locations and Study Status
80 April 11, 2007 Contacts/Locations and Study Status
81 April 18, 2007 Contacts/Locations and Study Status
82 April 25, 2007 Contacts/Locations and Study Status
83 May 2, 2007 Contacts/Locations and Study Status
84 May 3, 2007 Study Status and Contacts/Locations
85 May 8, 2007 Contacts/Locations and Study Status
86 May 16, 2007 Contacts/Locations and Study Status
87 May 23, 2007 Contacts/Locations and Study Status
88 June 4, 2007 Contacts/Locations and Study Status
89 June 6, 2007 Contacts/Locations and Study Status
90 June 13, 2007 Contacts/Locations and Study Status
91 June 20, 2007 Contacts/Locations and Study Status
92 June 25, 2007 Contacts/Locations and Study Status
93 July 3, 2007 Contacts/Locations and Study Status
94 July 10, 2007 Contacts/Locations and Study Status
95 July 17, 2007 Contacts/Locations and Study Status
96 July 30, 2007 Contacts/Locations and Study Status
97 August 8, 2007 Contacts/Locations and Study Status
98 August 21, 2007 Contacts/Locations and Study Status
99 August 24, 2007 Contacts/Locations and Study Status
100 August 28, 2007 Contacts/Locations and Study Status
101 September 5, 2007 Study Status and Contacts/Locations
102 September 10, 2007 Contacts/Locations and Study Status
103 September 18, 2007 Contacts/Locations and Study Status
104 September 20, 2007 Contacts/Locations and Study Status
105 September 25, 2007 Contacts/Locations and Study Status
106 September 27, 2007 Contacts/Locations and Study Status
107 October 1, 2007 Contacts/Locations and Study Status
108 October 5, 2007 Contacts/Locations and Study Status
109 October 13, 2007 Contacts/Locations and Study Status
110 October 17, 2007 Contacts/Locations and Study Status
111 October 19, 2007 Contacts/Locations and Study Status
112 October 25, 2007 Contacts/Locations, Arms and Interventions and Study Status
113 October 30, 2007 Contacts/Locations and Study Status
114 November 9, 2007 Study Status and Contacts/Locations
115 November 14, 2007 Contacts/Locations and Study Status
116 November 15, 2007 Contacts/Locations and Study Status
117 November 16, 2007 Contacts/Locations and Study Status
118 November 21, 2007 Contacts/Locations and Study Status
119 November 22, 2007 Contacts/Locations and Study Status
120 November 27, 2007 Contacts/Locations and Study Status
121 November 30, 2007 Contacts/Locations and Study Status
122 December 1, 2007 Contacts/Locations and Study Status
123 December 4, 2007 Recruitment Status, Study Status and Contacts/Locations
124 December 15, 2007 Arms and Interventions and Study Status
125 December 25, 2007 Study Status
126 April 30, 2008 Study Description and Study Status
127 May 23, 2008 Arms and Interventions and Study Status
128 July 23, 2008 Study Design and Study Status
129 August 12, 2008 Study Design, Study Description and Study Status
130 September 10, 2008 Recruitment Status, Study Status and Contacts/Locations
131 September 18, 2008 Recruitment Status, Study Status and Contacts/Locations
132 October 22, 2008 Study Status
133 November 20, 2008 Study Status and Contacts/Locations
134 November 25, 2008 Contacts/Locations and Study Status
135 November 28, 2008 Contacts/Locations and Study Status
136 December 3, 2008 Study Status and Contacts/Locations
137 December 4, 2008 Contacts/Locations and Study Status
138 December 6, 2008 Contacts/Locations and Study Status
139 December 9, 2008 Contacts/Locations and Study Status
140 December 10, 2008 Contacts/Locations and Study Status
141 December 16, 2008 Contacts/Locations and Study Status
142 December 17, 2008 Contacts/Locations and Study Status
143 December 19, 2008 Contacts/Locations and Study Status
144 December 24, 2008 Contacts/Locations and Study Status
145 December 25, 2008 Contacts/Locations and Study Status
146 December 31, 2008 Contacts/Locations and Study Status
147 January 6, 2009 Study Status and Contacts/Locations
148 January 7, 2009 Contacts/Locations and Study Status
149 January 9, 2009 Contacts/Locations and Study Status
150 January 10, 2009 Contacts/Locations and Study Status
151 January 14, 2009 Contacts/Locations and Study Status
152 January 15, 2009 Contacts/Locations and Study Status
153 January 16, 2009 Contacts/Locations and Study Status
154 January 21, 2009 Contacts/Locations and Study Status
155 January 22, 2009 Contacts/Locations and Study Status
156 January 28, 2009 Contacts/Locations and Study Status
157 January 29, 2009 Contacts/Locations and Study Status
158 January 30, 2009 Contacts/Locations and Study Status
159 February 3, 2009 Contacts/Locations and Study Status
160 February 7, 2009 Contacts/Locations and Study Status
161 February 10, 2009 Contacts/Locations and Study Status
162 February 11, 2009 Contacts/Locations and Study Status
163 February 12, 2009 Contacts/Locations and Study Status
164 February 14, 2009 Contacts/Locations and Study Status
165 February 17, 2009 Contacts/Locations and Study Status
166 February 19, 2009 Contacts/Locations and Study Status
167 February 21, 2009 Contacts/Locations and Study Status
168 February 25, 2009 Contacts/Locations and Study Status
169 February 27, 2009 Contacts/Locations and Study Status
170 March 5, 2009 Study Status and Contacts/Locations
171 March 7, 2009 Contacts/Locations and Study Status
172 March 10, 2009 Contacts/Locations and Study Status
173 March 11, 2009 Contacts/Locations and Study Status
174 March 13, 2009 Contacts/Locations and Study Status
175 March 17, 2009 Contacts/Locations and Study Status
176 March 18, 2009 Contacts/Locations and Study Status
177 March 19, 2009 Contacts/Locations and Study Status
178 March 21, 2009 Contacts/Locations and Study Status
179 March 27, 2009 Contacts/Locations and Study Status
180 March 31, 2009 Contacts/Locations and Study Status
181 April 3, 2009 Study Status and Contacts/Locations
182 April 6, 2009 Contacts/Locations and Study Status
183 April 7, 2009 Arms and Interventions and Study Status
184 April 8, 2009 Contacts/Locations and Study Status
185 April 9, 2009 Contacts/Locations and Study Status
186 April 10, 2009 Contacts/Locations and Study Status
187 April 11, 2009 Contacts/Locations and Study Status
188 April 14, 2009 Sponsor/Collaborators and Study Status
189 April 22, 2009 Contacts/Locations and Study Status
190 April 26, 2009 Contacts/Locations and Study Status
191 April 28, 2009 Contacts/Locations and Study Status
192 May 2, 2009 Study Status and Contacts/Locations
193 May 7, 2009 Contacts/Locations and Study Status
194 May 9, 2009 Contacts/Locations and Study Status
195 May 12, 2009 Contacts/Locations and Study Status
196 May 13, 2009 Contacts/Locations and Study Status
197 May 15, 2009 Contacts/Locations and Study Status
198 May 19, 2009 Contacts/Locations and Study Status
199 May 26, 2009 Contacts/Locations and Study Status
200 June 3, 2009 Contacts/Locations and Study Status
201 June 9, 2009 Contacts/Locations and Study Status
202 June 17, 2009 Contacts/Locations and Study Status
203 June 20, 2009 Contacts/Locations and Study Status
204 June 26, 2009 Contacts/Locations and Study Status
205 July 3, 2009 Study Status and Contacts/Locations
206 July 9, 2009 Contacts/Locations and Study Status
207 July 11, 2009 Contacts/Locations and Study Status
208 July 14, 2009 Contacts/Locations and Study Status
209 July 16, 2009 Contacts/Locations and Study Status
210 July 21, 2009 Contacts/Locations and Study Status
211 July 23, 2009 Contacts/Locations and Study Status
212 July 25, 2009 Contacts/Locations and Study Status
213 August 1, 2009 Contacts/Locations and Study Status
214 August 5, 2009 Study Status and Contacts/Locations
215 August 11, 2009 Contacts/Locations and Study Status
216 August 13, 2009 Contacts/Locations and Study Status
217 August 14, 2009 Contacts/Locations and Study Status
218 August 16, 2009 Contacts/Locations and Study Status
219 August 20, 2009 Contacts/Locations and Study Status
220 August 25, 2009 Contacts/Locations and Study Status
221 August 26, 2009 Contacts/Locations and Study Status
222 August 28, 2009 Contacts/Locations and Study Status
223 September 8, 2009 Study Status and Contacts/Locations
224 September 11, 2009 Contacts/Locations and Study Status
225 September 15, 2009 Contacts/Locations and Study Status
226 September 17, 2009 Contacts/Locations and Study Status
227 September 23, 2009 Contacts/Locations and Study Status
228 September 29, 2009 Contacts/Locations and Study Status
229 September 30, 2009 Contacts/Locations and Study Status
230 October 1, 2009 Contacts/Locations and Study Status
231 October 6, 2009 Study Status and Contacts/Locations
232 October 7, 2009 Contacts/Locations and Study Status
233 October 13, 2009 Contacts/Locations and Study Status
234 October 15, 2009 Contacts/Locations and Study Status
235 October 16, 2009 Contacts/Locations and Study Status
236 October 20, 2009 Contacts/Locations and Study Status
237 October 21, 2009 Contacts/Locations and Study Status
238 October 29, 2009 Contacts/Locations and Study Status
239 October 30, 2009 Contacts/Locations and Study Status
240 November 3, 2009 Contacts/Locations and Study Status
241 November 4, 2009 Study Status and Contacts/Locations
242 November 7, 2009 Contacts/Locations and Study Status
243 November 10, 2009 Contacts/Locations and Study Status
244 November 12, 2009 Contacts/Locations and Study Status
245 November 18, 2009 Contacts/Locations and Study Status
246 December 2, 2009 Study Status and Contacts/Locations
247 December 5, 2009 Contacts/Locations and Study Status
248 December 11, 2009 Contacts/Locations and Study Status
249 December 15, 2009 Contacts/Locations and Study Status
250 December 17, 2009 Contacts/Locations and Study Status
251 December 22, 2009 Contacts/Locations and Study Status
252 December 23, 2009 Contacts/Locations and Study Status
253 January 7, 2010 Study Status and Contacts/Locations
254 January 12, 2010 Contacts/Locations and Study Status
255 January 15, 2010 Contacts/Locations and Study Status
256 January 22, 2010 Contacts/Locations and Study Status
257 January 23, 2010 Contacts/Locations and Study Status
258 January 26, 2010 Contacts/Locations and Study Status
259 January 27, 2010 Contacts/Locations and Study Status
260 January 28, 2010 Contacts/Locations and Study Status
261 January 29, 2010 Contacts/Locations and Study Status
262 February 1, 2010 Contacts/Locations and Study Status
263 February 2, 2010 Contacts/Locations and Study Status
264 February 3, 2010 Study Status
265 February 4, 2010 Contacts/Locations and Study Status
266 February 6, 2010 Contacts/Locations and Study Status
267 February 11, 2010 Contacts/Locations and Study Status
268 February 16, 2010 Contacts/Locations and Study Status
269 February 18, 2010 Contacts/Locations and Study Status
270 February 19, 2010 Contacts/Locations and Study Status
271 February 20, 2010 Contacts/Locations and Study Status
272 February 23, 2010 Contacts/Locations and Study Status
273 February 25, 2010 Contacts/Locations and Study Status
274 February 26, 2010 Contacts/Locations and Study Status
275 March 2, 2010 Contacts/Locations and Study Status
276 March 3, 2010 Study Status and Contacts/Locations
277 March 4, 2010 Contacts/Locations and Study Status
278 March 9, 2010 Contacts/Locations and Study Status
279 March 10, 2010 Contacts/Locations and Study Status
280 March 11, 2010 Contacts/Locations and Study Status
281 March 12, 2010 Contacts/Locations and Study Status
282 March 16, 2010 Contacts/Locations and Study Status
283 March 18, 2010 Contacts/Locations and Study Status
284 March 22, 2010 Contacts/Locations and Study Status
285 March 24, 2010 Contacts/Locations and Study Status
286 March 26, 2010 Contacts/Locations and Study Status
287 March 27, 2010 Contacts/Locations and Study Status
288 March 30, 2010 Contacts/Locations and Study Status
289 April 1, 2010 Contacts/Locations and Study Status
290 April 6, 2010 Study Status and Contacts/Locations
291 April 7, 2010 Contacts/Locations and Study Status
292 April 8, 2010 Contacts/Locations and Study Status
293 April 13, 2010 Contacts/Locations and Study Status
294 April 15, 2010 Contacts/Locations and Study Status
295 April 17, 2010 Contacts/Locations and Study Status
296 April 21, 2010 Contacts/Locations and Study Status
297 May 8, 2010 Study Status and Contacts/Locations
298 May 11, 2010 Contacts/Locations and Study Status
299 May 12, 2010 Contacts/Locations and Study Status
300 May 15, 2010 Contacts/Locations and Study Status
301 May 18, 2010 Contacts/Locations and Study Status
302 May 27, 2010 Contacts/Locations and Study Status
303 May 28, 2010 Contacts/Locations and Study Status
304 June 5, 2010 Study Status and Contacts/Locations
305 June 8, 2010 Contacts/Locations and Study Status
306 June 9, 2010 Contacts/Locations and Study Status
307 June 11, 2010 Contacts/Locations and Study Status
308 June 19, 2010 Contacts/Locations and Study Status
309 June 22, 2010 Contacts/Locations and Study Status
310 June 24, 2010 Contacts/Locations and Study Status
311 June 25, 2010 Contacts/Locations and Study Status
312 June 26, 2010 Contacts/Locations and Study Status
313 June 29, 2010 Contacts/Locations and Study Status
314 July 2, 2010 Study Status and Contacts/Locations
315 July 3, 2010 Contacts/Locations and Study Status
316 July 13, 2010 Contacts/Locations and Study Status
317 July 14, 2010 Contacts/Locations and Study Status
318 July 17, 2010 Contacts/Locations and Study Status
319 July 21, 2010 Contacts/Locations and Study Status
320 July 28, 2010 Contacts/Locations, Sponsor/Collaborators and Study Status
321 August 3, 2010 Study Status and Contacts/Locations
322 August 5, 2010 Contacts/Locations and Study Status
323 August 6, 2010 Contacts/Locations and Study Status
324 August 10, 2010 Contacts/Locations and Study Status
325 August 11, 2010 Contacts/Locations and Study Status
326 August 14, 2010 Contacts/Locations and Study Status
327 August 18, 2010 Contacts/Locations and Study Status
328 August 20, 2010 Contacts/Locations and Study Status
329 August 24, 2010 Contacts/Locations and Study Status
330 August 29, 2010 Contacts/Locations and Study Status
331 September 10, 2010 Contacts/Locations and Study Status
332 September 17, 2010 Conditions and Study Status
333 September 18, 2010 Contacts/Locations and Study Status
334 September 24, 2010 Contacts/Locations and Study Status
335 September 25, 2010 Contacts/Locations and Study Status
336 September 28, 2010 Contacts/Locations and Study Status
337 October 6, 2010 Study Status and Contacts/Locations
338 October 8, 2010 Contacts/Locations and Study Status
339 October 12, 2010 Contacts/Locations and Study Status
340 October 13, 2010 Contacts/Locations and Study Status
341 October 16, 2010 Contacts/Locations and Study Status
342 October 19, 2010 Contacts/Locations and Study Status
343 October 20, 2010 Contacts/Locations and Study Status
344 October 21, 2010 Contacts/Locations and Study Status
345 October 23, 2010 Contacts/Locations and Study Status
346 October 26, 2010 Contacts/Locations and Study Status
347 October 28, 2010 Contacts/Locations and Study Status
348 October 29, 2010 Contacts/Locations and Study Status
349 October 30, 2010 Contacts/Locations and Study Status
350 November 2, 2010 Contacts/Locations and Study Status
351 November 3, 2010 Contacts/Locations and Study Status
352 November 5, 2010 Contacts/Locations and Study Status
353 November 9, 2010 Contacts/Locations and Study Status
354 November 10, 2010 Contacts/Locations and Study Status
355 November 12, 2010 Contacts/Locations and Study Status
356 November 18, 2010 Contacts/Locations and Study Status
357 November 20, 2010 Contacts/Locations and Study Status
358 November 23, 2010 Contacts/Locations and Study Status
359 December 1, 2010 Contacts/Locations and Study Status
360 December 4, 2010 Study Status and Contacts/Locations
361 December 7, 2010 Contacts/Locations and Study Status
362 December 8, 2010 Contacts/Locations and Study Status
363 December 15, 2010 Contacts/Locations and Study Status
364 December 16, 2010 Contacts/Locations and Study Status
365 December 21, 2010 Contacts/Locations and Study Status
366 December 22, 2010 Contacts/Locations and Study Status
367 December 24, 2010 Contacts/Locations and Study Status
368 January 7, 2011 Study Status
369 January 8, 2011 Contacts/Locations and Study Status
370 January 20, 2011 Contacts/Locations and Study Status
371 January 25, 2011 Contacts/Locations and Study Status
372 January 26, 2011 Contacts/Locations and Study Status
373 January 27, 2011 Contacts/Locations and Study Status
374 February 5, 2011 Study Status and Contacts/Locations
375 February 10, 2011 Contacts/Locations and Study Status
376 February 15, 2011 Contacts/Locations and Study Status
377 February 22, 2011 Contacts/Locations and Study Status
378 February 25, 2011 Contacts/Locations and Study Status
379 March 1, 2011 Contacts/Locations and Study Status
380 March 3, 2011 Study Status and Contacts/Locations
381 March 4, 2011 Contacts/Locations and Study Status
382 March 9, 2011 Contacts/Locations and Study Status
383 March 11, 2011 Contacts/Locations and Study Status
384 March 16, 2011 Recruitment Status, Study Status and Contacts/Locations
385 April 5, 2011 Study Status
386 February 8, 2012 Outcome Measures, Sponsor/Collaborators, Study Status, Study Identification, Contacts/Locations, Study Design, Study Description and Oversight
387 July 26, 2012 Study Design, Study Status and Study Identification
388 May 15, 2013 Contacts/Locations, Study Identification, Arms and Interventions, Outcome Measures, Sponsor/Collaborators, Study Status, Study Design, Conditions, Study Description, References, Eligibility and Oversight
389 November 6, 2013 Contacts/Locations, Study Identification, Arms and Interventions, Outcome Measures, Sponsor/Collaborators, Study Status, Study Design, Conditions, Study Description, References, Eligibility and Oversight
390 May 16, 2014 Study Status and Eligibility
391 June 3, 2014 Contacts/Locations and Study Status
392 July 10, 2014 Contacts/Locations and Study Status
393 March 24, 2015 Study Status and Outcome Measures
394 March 7, 2016 Study Status, Arms and Interventions, Outcome Measures, Study Identification, References, Results, Eligibility, Study Description and Oversight
395 September 26, 2016 Study Identification and Study Status
396 December 22, 2017 Contacts/Locations, Study Status and Outcome Measures
397 March 15, 2019 Outcome Measures and Study Status
398 March 9, 2020 Outcome Measures and Study Status
399 March 18, 2020 Study Status
400 August 4, 2020 Study Status
401 February 12, 2021 Study Status
402 November 15, 2022 Study Status and Study Identification
403 December 14, 2023 More Information, Study Status and References
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Study NCT00066703
Submitted Date:  June 23, 2005 (v1)
Open or close this module Study Identification
Unique Protocol ID: CDR0000316458
Brief Title: Triptorelin With Either Exemestane or Tamoxifen in Treating Premenopausal Women With Hormone-Responsive Breast Cancer
Official Title: Phase III Randomized Study of Triptorelin and Exemestane Versus Triptorelin and Tamoxifen in Premenopausal Women With Endocrine-Responsive Breast Cancer
Secondary IDs: IBCSG-25-02
BIG-3-02
NABCI-IBCSG-25-02
EU-20347
NCT00066703
Open or close this module Study Status
Record Verification: February 2005
Overall Status: Recruiting
Study Start:
Primary Completion:
Study Completion:
First Submitted: August 6, 2003
First Submitted that
Met QC Criteria:		 August 6, 2003
First Posted: August 7, 2003 [Estimate]
Last Update Submitted that
Met QC Criteria:		 June 23, 2005
Last Update Posted: June 24, 2005 [Estimate]
Open or close this module Sponsor/Collaborators
Sponsor: ETOP IBCSG Partners Foundation
Responsible Party:
Collaborators: National Cancer Institute (NCI)
Breast International Group
Open or close this module Oversight
U.S. FDA-regulated Drug:
U.S. FDA-regulated Device:
Data Monitoring:
Open or close this module Study Description
Brief Summary:

RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using triptorelin, exemestane, and tamoxifen may fight breast cancer by blocking the uptake of estrogen. It is not yet known whether giving triptorelin together with exemestane is more effective than triptorelin and tamoxifen in treating hormone-responsive breast cancer.

PURPOSE: This randomized phase III trial is studying triptorelin and exemestane to see how well they work compared to triptorelin and tamoxifen in treating premenopausal women with hormone-responsive breast cancer.
Detailed Description:

OBJECTIVES:

  • Compare the disease-free and overall survival of premenopausal women with endocrine-responsive breast cancer when treated with triptorelin and exemestane vs triptorelin and tamoxifen.
  • Compare the quality of life, including late side effects of early menopause, of patients treated with these regimens.
  • Compare the sites of first treatment failure in patients treated with these regimens.
  • Compare the incidence of second (non-breast) malignancies in patients treated with these regimens.

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to participating center, concurrent adjuvant chemotherapy (yes vs no), and number of positive axillary and/or internal mammary lymph nodes (0 vs 1 or more). Patients are randomized to 1 of 2 treatment arms.

  • Arm I: Patients receive triptorelin intramuscularly on day 1 every 28 days. Patients in the adjuvant chemotherapy stratum receive chemotherapy concurrently with triptorelin for at least 2 months (if anthracycline is included) or at least 4 months (if no anthracycline is included). Beginning after the completion of chemotherapy or at least 6 weeks after the initiation of triptorelin, patients receive oral tamoxifen daily.
  • Arm II: Patients receive triptorelin as in arm I. Beginning after the completion of adjuvant chemotherapy or at least 6 weeks after the initiation of triptorelin, patients also receive oral exemestane daily.

In both arms, treatment continues for 5 years in the absence of disease progression or unacceptable toxicity.

Quality of life is assessed at baseline, every 6 months for 2 years, and annually for 3 years.

Patients are followed every 3 months for 1 year, every 6 months for 5 years, and then annually thereafter.

PROJECTED ACCRUAL: A total of 1,845 patients will be accrued for this study within 4.5 years.
Open or close this module Conditions
Conditions: stage I breast cancer
stage II breast cancer
stage IIIA breast cancer
Keywords:
Open or close this module Study Design
Study Type: Interventional
Primary Purpose: Treatment
Study Phase: Phase 3
Interventional Study Model:
Number of Arms:
Masking: (masked roles unspecified)
Enrollment:
Open or close this module Arms and Interventions
Intervention Details:
Drug: exemestane
Drug: tamoxifen
Drug: triptorelin
Procedure: adjuvant therapy
Procedure: antiestrogen therapy
Procedure: antiprogestational therapy
Procedure: aromatase inhibition
Procedure: endocrine therapy
Procedure: hormone therapy
Procedure: releasing factor agonist therapy
Open or close this module Outcome Measures
Open or close this module Eligibility
Minimum Age: 0 Years
Maximum Age:
Sex: All
Gender Based:
Accepts Healthy Volunteers: No
Criteria:

DISEASE CHARACTERISTICS:

  • Histologically confirmed breast cancer
  • Completely resected disease
  • No clinically detectable residual loco-regional axillary disease
  • Prior surgery for primary breast cancer of 1 of the following types:
  • Total mastectomy with or without adjuvant radiotherapy
  • Breast-conserving procedure (e.g., lumpectomy, quadrantectomy, or partial mastectomy with margins negative for invasive disease and ductal carcinoma in situ) with planned radiotherapy
  • Tumor confined to the breast and axillary nodes
  • Tumor detected in internal mammary chain nodes by sentinel node procedure and is not enlarged is allowed
  • Axillary lymph node dissection or a negative axillary sentinel node biopsy required
  • Patients with microscopically positive axillary sentinel nodes are eligible if they are randomized in a clinical study evaluating those lymph nodes
  • No distant metastases
  • No locally advanced inoperable breast cancer, including any of the following:
  • Inflammatory breast cancer
  • Supraclavicular node involvement
  • Enlarged internal mammary nodes (unless pathologically negative)
  • No bilateral invasive breast cancer
  • No prior ipsilateral or contralateral invasive breast cancer
  • Hormone receptor status:
  • Estrogen and/or progesterone receptor positive
  • At least 10% of the tumor cells positive by immunohistochemistry

PATIENT CHARACTERISTICS:

Age

  • Premenopausal

Sex

  • Female

Menopausal status

  • Premenopausal
  • Estradiol in the premenopausal range after prior surgery

Performance status

  • Not specified

Life expectancy

  • Not specified

Hematopoietic

  • Not specified

Hepatic

  • No systemic hepatic disease that would preclude prolonged follow-up

Renal

  • No systemic renal disease that would preclude prolonged follow-up

Cardiovascular

  • No systemic cardiovascular disease that would preclude prolonged follow-up
  • No prior thrombosis (e.g., deep vein thrombosis) and/or embolism unless patient is medically suitable

Pulmonary

  • No systemic pulmonary disease that would preclude prolonged follow-up

Other

  • Not pregnant or nursing
  • Fertile patients must use effective nonhormonal contraception
  • No history of noncompliance to medical regimens
  • No other nonmalignant systemic disease that would preclude prolonged follow-up
  • No prior or concurrent malignancy except adequately treated basal cell or squamous cell skin cancer, carcinoma in situ of the cervix or bladder, or contralateral or ipsilateral carcinoma in situ of the breast
  • No psychiatric, addictive, or other disorder that would preclude ability to provide informed consent

PRIOR CONCURRENT THERAPY:

Biologic therapy

  • Not specified

Chemotherapy

  • No prior neoadjuvant or adjuvant chemotherapy

Endocrine therapy

  • No prior tamoxifen, other selective estrogen-receptor modulators (SERMs) (e.g., raloxifene), or hormone replacement therapy for more than 1 year before breast cancer diagnosis
  • No prior neoadjuvant or adjuvant endocrine therapy since diagnosis of breast cancer
  • No concurrent oral or transdermal hormonal therapy
  • No other concurrent estrogen, progesterone, or androgens
  • No other concurrent aromatase inhibitors
  • No concurrent hormone replacement therapy
  • No concurrent oral or other hormonal contraceptives (i.e., implants or depot injections)
  • No concurrent SERMs (e.g., raloxifene)

Radiotherapy

  • See Disease Characteristics
  • No prior ovarian radiotherapy

Surgery

  • See Disease Characteristics
  • No prior bilateral oophorectomy

Other

  • No concurrent bisphosphonates, except in the following cases:
  • Bone density is at least 1.5 standard deviations below the young adult normal mean
  • Participation in a randomized clinical study testing bisphosphonates in the adjuvant breast cancer setting
  • No other concurrent investigational agents
Open or close this module Contacts/Locations
Study Officials: Barbara A. Walley, MD, FRCPC
Study Chair
Tom Baker Cancer Centre - Calgary
Olivia Pagani, MD
Study Chair
Ospedale Beata Vergine
Locations: United States, Arizona
CCOP - Mayo Clinic Scottsdale Oncology Program
[Recruiting]
Scottsdale, Arizona, United States, 85259
Contact:Contact: Mathew P. Goetz, MD 507-284-4849
United States, Arkansas
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
[Recruiting]
Little Rock, Arkansas, United States, 72205
Contact:Contact: Laura F. Hutchins, MD 501-686-8274
United States, California
Providence Saint Joseph Medical Center - Burbank
[Recruiting]
Burbank, California, United States, 91505
Contact:Contact: Raul R. Mena, MD 818-840-0921
Lucy Curci Cancer Center at Eisenhower Memorial Hospital and Medical Center
[Recruiting]
Rancho Mirage, California, United States, 92270
Contact:Contact: Robert H. Lemon, MD 760-568-4461x144
Sutter Roseville Medical Center
[Recruiting]
Roseville, California, United States, 95661
Contact:Contact: Vincent Caggiano, MD 916-454-6595
Sutter Cancer Center
[Recruiting]
Sacramento, California, United States, 95816
Contact:Contact: Vincent Caggiano, MD 916-454-6595
United States, Colorado
University of Colorado Cancer Center at University of Colorado Health Sciences Center
[Recruiting]
Denver, Colorado, United States, 80217-3364
Contact:Contact: Anthony D. Elias, MD 720-848-0300
United States, Florida
Lynn Regional Cancer Center of Boca Raton Community Hospital
[Recruiting]
Boca Raton, Florida, United States, 33428
Contact:Contact: Elena Kruglyak 561-883-7600
Mayo Clinic - Jacksonville
[Recruiting]
Jacksonville, Florida, United States, 32224-9980
Contact:Contact: Mathew P. Goetz, MD 507-284-4849
University of Miami Sylvester Comprehensive Cancer Center
[Recruiting]
Miami, Florida, United States, 33136
Contact:Contact: Stefan Gluck, MD, PhD, FRCPC 305-243-4909
United States, Georgia
Northeast Georgia Medical Center
[Recruiting]
Gainesville, Georgia, United States, 30501
Contact:Contact: Richard J. LoCicero, MD 770-535-3553
United States, Idaho
Mountain States Tumor Institute - Boise
[Recruiting]
Boise, Idaho, United States, 83712
Contact:Contact: Theodore A. Walters, MD 208-381-2857
North Idaho Cancer Center
[Recruiting]
Coeur D Alene, Idaho, United States, 83814
Contact:Contact: Haluk Tezcan, MD 208-666-3800
United States, Illinois
St. Joseph Medical Center
[Recruiting]
Bloomington, Illinois, United States, 61701
Contact:Contact: John W. Kugler, MD 309-243-3000
Graham Hospital
[Recruiting]
Canton, Illinois, United States, 61520
Contact:Contact: John W. Kugler, MD 309-243-3000
Memorial Hospital
[Recruiting]
Carthage, Illinois, United States, 62321
Contact:Contact: John W. Kugler, MD 309-243-3000
John H. Stroger, Jr. Hospital of Cook County
[Recruiting]
Chicago, Illinois, United States, 60612-3785
Contact:Contact: Keith A. Dookeran, MD 312-864-5204
University of Chicago Cancer Research Center
[Recruiting]
Chicago, Illinois, United States, 60637-1470
Contact:Contact: Gini F. Fleming, MD 773-702-6712
Eureka Hospital
[Recruiting]
Eureka, Illinois, United States, 61530
Contact:Contact: John W. Kugler, MD 309-243-3000
Evanston Northwestern Health Care - Evanston Hospital
[Recruiting]
Evanston, Illinois, United States, 60201
Contact:Contact: Douglas E. Merkel, MD 847-570-2515
Galesburg Clinic
[Recruiting]
Galesburg, Illinois, United States, 61401
Contact:Contact: John W. Kugler, MD 309-243-3000
Galesburg Cottage Hospital
[Recruiting]
Galesburg, Illinois, United States, 61401
Contact:Contact: John W. Kugler, MD 309-243-3000
Mason District Hospital
[Recruiting]
Havana, Illinois, United States, 62644
Contact:Contact: John W. Kugler, MD 309-243-3000
Hopedale Medical Complex
[Recruiting]
Hopedale, Illinois, United States, 61747
Contact:Contact: John W. Kugler, MD 309-243-3000
Kewanee Hospital
[Recruiting]
Kewanee, Illinois, United States, 61443
Contact:Contact: John W. Kugler, MD 309-243-3000
McDonough District Hospital
[Recruiting]
Macomb, Illinois, United States, 61455
Contact:Contact: John W. Kugler, MD 309-243-3000
BroMenn Regional Medical Center
[Recruiting]
Normal, Illinois, United States, 61761
Contact:Contact: John W. Kugler, MD 309-243-3000
Community Cancer Center
[Recruiting]
Normal, Illinois, United States, 61761
Contact:Contact: John W. Kugler, MD 309-243-3000
Community Hospital of Ottawa
[Recruiting]
Ottawa, Illinois, United States, 61350
Contact:Contact: John W. Kugler, MD 309-243-3000
Cancer Treatment Center at Pekin Hospital
[Recruiting]
Pekin, Illinois, United States, 61554
Contact:Contact: John W. Kugler, MD 309-243-3000
Methodist Medical Center of Illinois
[Recruiting]
Peoria, Illinois, United States, 61603
Contact:Contact: John W. Kugler, MD 309-243-3000
Proctor Hospital
[Recruiting]
Peoria, Illinois, United States, 61614
Contact:Contact: John W. Kugler, MD 309-243-3000
CCOP - Illinois Oncology Research Association
[Recruiting]
Peoria, Illinois, United States, 61615
Contact:Contact: John W. Kugler, MD 309-243-3000
Oncology/Hematology Associates of Central Illinois, P.C.
[Recruiting]
Peoria, Illinois, United States, 61615
Contact:Contact: John W. Kugler, MD 309-243-3000
OSF St. Francis Medical Center
[Recruiting]
Peoria, Illinois, United States, 61637
Contact:Contact: John W. Kugler, MD 309-243-3000
Illinois Valley Community Hospital
[Recruiting]
Peru, Illinois, United States, 61354
Contact:Contact: John W. Kugler, MD 309-243-3000
Perry Memorial Hospital
[Recruiting]
Princeton, Illinois, United States, 61356
Contact:Contact: John W. Kugler, MD 309-243-3000
St. Margaret's Hospital
[Recruiting]
Spring Valley, Illinois, United States, 61362
Contact:Contact: John W. Kugler, MD 309-243-3000
CCOP - Carle Cancer Center
[Recruiting]
Urbana, Illinois, United States, 61801
Contact:Contact: Kendrith M. Rowland, MD 217-383-3010
United States, Indiana
Elkhart General Hospital
[Recruiting]
Elkhart, Indiana, United States, 46515
Contact:Contact: Rafat H. Ansari, MD, FACP 574-234-5123
Fort Wayne Medical Oncology and Hematology, Incorporated
[Recruiting]
Fort Wayne, Indiana, United States, 46815
Contact:Contact: Sreenivasa R. Nattam, MD 260-484-8830
Center for Cancer Therapy at LaPorte Hospital and Health Services
[Recruiting]
La Porte, Indiana, United States, 46350
Contact:Contact: Rafat H. Ansari, MD, FACP 574-234-5123
Saint Joseph Regional Medical Center - Plymouth Campus
[Recruiting]
Plymouth, Indiana, United States, 46544
Contact:Contact: Rafat H. Ansari, MD, FACP 574-234-5123
CCOP - Northern Indiana CR Consortium
[Recruiting]
South Bend, Indiana, United States, 46601
Contact:Contact: Rafat H. Ansari, MD, FACP 574-234-5123
Memorial Hospital of South Bend
[Recruiting]
South Bend, Indiana, United States, 46601
Contact:Contact: Rafat H. Ansari, MD, FACP 574-234-5123
United States, Iowa
Siouxland Hematology-Oncology Associates
[Recruiting]
Sioux City, Iowa, United States, 51101
Contact:Contact: Donald B. Wender, MD, PhD 712-252-9326
United States, Kansas
South Central Kansas Regional Medical Center
[Recruiting]
Arkansas City, Kansas, United States, 67005
Contact:Contact: Shaker R. Dakhil, MD, FACP 316-262-4467
Cancer Center of Kansas - Chanute
[Recruiting]
Chanute, Kansas, United States, 66720
Contact:Contact: Shaker R. Dakhil, MD, FACP 316-262-4467
Cancer Center of Kansas - Dodge City
[Recruiting]
Dodge City, Kansas, United States, 67801
Contact:Contact: Shaker R. Dakhil, MD, FACP 316-262-4467
Cancer Center of Kansas - Kingman
[Recruiting]
Kingman, Kansas, United States, 67068
Contact:Contact: Shaker R. Dakhil, MD, FACP 316-262-4467
Southwest Medical Center
[Recruiting]
Liberal, Kansas, United States, 67901
Contact:Contact: Shaker R. Dakhil, MD, FACP 316-262-4467
Cancer Center of Kansas - Newton
[Recruiting]
Newton, Kansas, United States, 67114
Contact:Contact: Shaker R. Dakhil, MD, FACP 316-262-4467
Cancer Center of Kansas - Salina
[Recruiting]
Salina, Kansas, United States, 67042
Contact:Contact: Shaker R. Dakhil, MD, FACP 316-262-4467
Cancer Center at Stormont-Vail Regional Health Center
[Recruiting]
Topeka, Kansas, United States, 66604
Contact:Contact: Stanley J. Vogel, MD 785-354-0544
Cancer Center of Kansas - Wellington
[Recruiting]
Wellington, Kansas, United States, 67152
Contact:Contact: Shaker R. Dakhil, MD, FACP 316-262-4467
Associates in Womens Health
[Recruiting]
Wichita, Kansas, United States, 67203
Contact:Contact: Shaker R. Dakhil, MD, FACP 316-262-4467
Cancer Center of Kansas, P.A.
[Recruiting]
Wichita, Kansas, United States, 67208
Contact:Contact: Shaker R. Dakhil, MD, FACP 316-262-4467
Cancer Center of Kansas, P.A. - Wichita
[Recruiting]
Wichita, Kansas, United States, 67214
Contact:Contact: Shaker R. Dakhil, MD, FACP 316-262-4467
CCOP - Wichita
[Recruiting]
Wichita, Kansas, United States, 67214
Contact:Contact: Shaker R. Dakhil, MD, FACP 316-262-4467
Via Christi Cancer Center at Via Christi Regional Medical Center
[Recruiting]
Wichita, Kansas, United States, 67214
Contact:Contact: Shaker R. Dakhil, MD, FACP 316-262-4467
Cancer Center of Kansas - Winfield
[Recruiting]
Winfield, Kansas, United States, 67156
Contact:Contact: Shaker R. Dakhil, MD, FACP 316-262-4467
United States, Maryland
Greenebaum Cancer Center at University of Maryland Medical Center
[Recruiting]
Baltimore, Maryland, United States, 21201-1595
Contact:Contact: Wei Song, MD 610-327-7555
Mercy Medical Center
[Recruiting]
Baltimore, Maryland, United States, 21202
Contact:Contact: David A. Riseberg, MD 410-783-5858
Suburban Hospital
[Recruiting]
Bethesda, Maryland, United States, 20814
Contact:Contact: Carolyn Bennett Hendricks, MD 301-897-1503
Frederick Memorial Hospital Regional Cancer Therapy Center
[Recruiting]
Frederick, Maryland, United States, 21701
Contact:Contact: Brian M. O'Connor, MD 301-662-8477
United States, Massachusetts
Beverly Hospital
[Recruiting]
Beverly, Massachusetts, United States, 01915
Contact:Contact: Angus McIntyre, MD 978-281-6460
Massachusetts General Hospital Cancer Center
[Recruiting]
Boston, Massachusetts, United States, 02114
Contact:Contact: Harold J. Burstein, MD, PhD 617-632-3800
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
[Recruiting]
Boston, Massachusetts, United States, 02115
Contact:Contact: Harold J. Burstein, MD, PhD 617-632-3800
Faulkner Hospital
[Recruiting]
Boston, Massachusetts, United States, 02130
Contact:Contact: Harold J. Burstein, MD, PhD 617-632-3800
Beth Israel Deaconess Medical Center
[Recruiting]
Boston, Massachusetts, United States, 02215
Contact:Contact: Harold J. Burstein, MD, PhD 617-632-3800
Bethke Cancer Center at Emerson Hospital
[Recruiting]
Concord, Massachusetts, United States, 01742
Contact:Contact: Harold J. Burstein, MD, PhD 617-632-3800
Addison Gilbert Hospital
[Recruiting]
Gloucester, Massachusetts, United States, 01930
Contact:Contact: Angus McIntyre, MD 978-281-6460
Cape Cod Hospital
[Recruiting]
Hyannis, Massachusetts, United States, 02601
Contact:Contact: James C. Chingos, MD 508-862-7575
NSMC Cancer Center - Peabody
[Recruiting]
Peabody, Massachusetts, United States, 01960
Contact:Contact: Karen Krag, MD 978-977-3434
United States, Michigan
CCOP - Michigan Cancer Research Consortium
[Recruiting]
Ann Arbor, Michigan, United States, 48100
Contact:Contact: Salam A. Jafar, MD 734-712-3596
St. Joseph Mercy Cancer Center at St. Joseph Mercy Hospital
[Recruiting]
Ann Arbor, Michigan, United States, 48106-0995
Contact:Contact: Salam A. Jafar, MD 734-712-3596
Seton Cancer Institute - Saginaw
[Recruiting]
Saginaw, Michigan, United States, 48601
Contact:Contact: Salam A. Jafar, MD 734-712-3596
St. John Macomb Hospital
[Recruiting]
Warren, Michigan, United States, 48903
Contact:Contact: Salam A. Jafar, MD 734-712-3596
United States, Minnesota
Fairview Ridges Hospital
[Recruiting]
Burnsville, Minnesota, United States, 55337
Contact:Contact: Patrick J. Flynn, MD 612-863-8585
Mercy Hospital
[Recruiting]
Coon Rapids, Minnesota, United States, 55433
Contact:Contact: Patrick J. Flynn, MD 612-863-8585
Fairview Southdale Hospital
[Recruiting]
Edina, Minnesota, United States, 55435
Contact:Contact: Patrick J. Flynn, MD 612-863-8585
Mercy and Unity Cancer Center at Mercy and Unity Hospitals
[Recruiting]
Fridley, Minnesota, United States, 55432
Contact:Contact: Patrick J. Flynn, MD 612-863-8585
Virginia Piper Cancer Institute at Abbott-Northwestern Hospital
[Recruiting]
Minneapolis, Minnesota, United States, 55403
Contact:Contact: Patrick J. Flynn, MD 612-863-8585
Hubert H. Humphrey Cancer Center at North Memorial Medical Center
[Recruiting]
Robbinsdale, Minnesota, United States, 55422
Contact:Contact: Patrick J. Flynn, MD 612-863-8585
Mayo Clinic Cancer Center
[Recruiting]
Rochester, Minnesota, United States, 55905
Contact:Contact: Mathew P. Goetz, MD 507-284-2511
CCOP - Metro-Minnesota
[Recruiting]
Saint Louis Park, Minnesota, United States, 55416
Contact:Contact: Patrick J. Flynn, MD 612-863-8585
Park Nicollet Clinic
[Recruiting]
St. Louis Park, Minnesota, United States, 55416
Contact:Contact: Patrick J. Flynn, MD 612-863-8585
United Hospital
[Recruiting]
St. Paul, Minnesota, United States, 55102
Contact:Contact: Patrick J. Flynn, MD 612-863-8585
Ridgeview Medical Center
[Recruiting]
Waconia, Minnesota, United States, 55387
Contact:Contact: Patrick J. Flynn, MD 612-863-8585
United States, Missouri
CCOP - Kansas City
[Recruiting]
Kansas City, Missouri, United States, 64131
Contact:Contact: Jorge C. Paradelo, MD, FACR 816-823-0555
St. John's Regional Health Center
[Recruiting]
Springfield, Missouri, United States, 65804
Contact:Contact: John W. Goodwin, MD 417-889-8099
Hulston Cancer Center at Cox Medical Center South
[Recruiting]
Springfield, Missouri, United States, 65807
Contact:Contact: John W. Goodwin, MD 417-889-8099
Siteman Cancer Center at Barnes-Jewish Hospital
[Recruiting]
St. Louis, Missouri, United States, 63110
Contact:Contact: Matthew J. Ellis, MD, PhD, FRCP 314-362-8866
United States, Montana
CCOP - Montana Cancer Consortium
[Recruiting]
Billings, Montana, United States, 59101
Contact:Contact: Patrick W. Cobb, MD 406-259-2245
Great Falls Clinic
[Recruiting]
Great Falls, Montana, United States, 59405
Contact:Contact: Thomas A. Warr, MD 406-727-4584
Sletten Regional Cancer Institute
[Recruiting]
Great Falls, Montana, United States, 59405
Contact:Contact: Thomas A. Warr, MD 406-727-4584
United States, New Hampshire
Portsmouth Regional Hospital
[Recruiting]
Portsmouth, New Hampshire, United States, 03802
Contact:Contact: Eric M. Bonnem, MD 603-433-5226
United States, New Jersey
Ocean Medical Center at Meridian Health
[Recruiting]
Brick, New Jersey, United States, 08724
Contact:Contact: William A. Lerner, MD, FACP 732-528-0760
CCOP - Northern New Jersey
[Recruiting]
Hackensack, New Jersey, United States, 07601
Contact:Contact: Norman G. Rosenblum, MD, PhD 201-996-5900
South Jersey Healthcare Regional Cancer Center
[Recruiting]
Millville, New Jersey, United States, 08332
Contact:Contact: David H. Blom, DO 856-696-9550
Carol G. Simon Cancer Center at Morristown Memorial Hospital
[Recruiting]
Morristown, New Jersey, United States, 07962
Contact:Contact: Steven W. Papish, MD 973-538-5210
Overlook Hospital
[Recruiting]
Summit, New Jersey, United States, 07902
Contact:Contact: Steven W. Papish, MD 973-538-5210
United States, New York
Albert Einstein Cancer Center at Albert Einstein College of Medicine
[Recruiting]
Bronx, New York, United States, 10461
Contact:Contact: Christine M. Pellegrino, MD 718-920-7100
United States, North Carolina
Randolph Hospital
[Recruiting]
Asheboro, North Carolina, United States, 27203
Contact:Contact: John E. Feldmann 336-625-5151
Hope A Women's Cancer Center
[Recruiting]
Asheville, North Carolina, United States, 28801
Contact:Contact: David J. Hetzel, MD 828-670-8403
Mission Hospitals - Memorial Campus
[Recruiting]
Asheville, North Carolina, United States, 28801
Contact:Contact: David J. Hetzel, MD 828-670-8403
Presbyterian Cancer Center at Presbyterian Hospital
[Recruiting]
Charlotte, North Carolina, United States, 28233
Contact:Contact: Richard B. Reiling 704-384-9955
John Smith, Jr./Dalton McMichael Cancer Center at Morehead Memorial Hospital
[Recruiting]
Eden, North Carolina, United States, 27288
Contact:Contact: John E. Feldmann 336-623-9713
Wayne Memorial Hospital, Incorporated
[Recruiting]
Goldsboro, North Carolina, United States, 27534
Contact:Contact: James N. Atkins, MD 919-580-0000
Moses Cone Regional Cancer Center at Wesley Long Community Hospital
[Recruiting]
Greensboro, North Carolina, United States, 27401
Contact:Contact: John E. Feldmann 336-832-1100
Pardee Memorial Hospital
[Recruiting]
Hendersonville, North Carolina, United States, 28791
Contact:Contact: James E. Radford, MD 828-692-8045
Lenoir Memorial Cancer Center
[Recruiting]
Kinston, North Carolina, United States, 28501
Contact:Contact: Peter R. Watson, MD 252-559-2201
Annie Penn Cancer Center
[Recruiting]
Reidsville, North Carolina, United States, 27320
Contact:Contact: John E. Feldmann 336-951-4584
Forsyth Regional Cancer Center at Forsyth Medical Center
[Recruiting]
Winston Salem, North Carolina, United States, 27103
Contact:Contact: Judith O. Hopkins, MD 336-277-8800
United States, North Dakota
Medcenter One Health System
[Recruiting]
Bismarck, North Dakota, United States, 58501
Contact:Contact: Edward J. Wos, DO 701-323-5741
Mid Dakota Clinic, P.C.
[Recruiting]
Bismarck, North Dakota, United States, 58501
Contact:Contact: Edward J. Wos, DO 701-323-5741
United States, Ohio
St. Elizabeth Boardman Cancer Center
[Recruiting]
Boardman, Ohio, United States, 44512
Contact:Contact: Antoine E. Chahine, MD 330-533-3040
MetroHealth's Cancer Care Center at MetroHealth Medical Center
[Recruiting]
Cleveland, Ohio, United States, 44109
Contact:Contact: Bruce Averbook, MD, FACS 216-778-4795
St. Joseph Health Care Center
[Recruiting]
Warren, Ohio, United States, 44484
Contact:Contact: Antoine E. Chahine, MD 330-533-3040
St. Elizabeth Cancer Center at St. Elizabeth Health Center - Youngstown
[Recruiting]
Youngstown, Ohio, United States, 44510
Contact:Contact: Antoine E. Chahine, MD 330-533-3040
United States, Oklahoma
Comanche County Memorial Hospital
[Recruiting]
Lawton, Oklahoma, United States, 73505
Contact:Contact: Nadim F. Nimeh, MD 580-355-8699 ext. 4200
Natalie Warren Bryant Cancer Center at St. Francis Hospital
[Recruiting]
Tulsa, Oklahoma, United States, 74136
Contact:Contact: David R. Barnes, MD, FACS 918-494-8275
United States, Pennsylvania
Joan Karnell Cancer Center at Pennsylvania Hospital
[Recruiting]
Philadelphia, Pennsylvania, United States, 19107
Contact:Contact: Bernard A. Mason, MD 215-829-6088
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
[Recruiting]
Philadelphia, Pennsylvania, United States, 19107
Contact:Contact: Gloria J. Morris 215-955-4652
United States, South Carolina
McLeod Regional Medical Center
[Recruiting]
Florence, South Carolina, United States, 29506
Contact:Contact: Rajesh Bajaj, MD 843-667-0816
CCOP - Greenville
[Recruiting]
Greenville, South Carolina, United States, 29615
Contact:Contact: Jeffrey K. Giguere, MD 864-241-6251
United States, South Dakota
Sioux Valley Hospital and University of South Dakota Medical Center
[Recruiting]
Sioux Falls, South Dakota, United States, 57104
Contact:Contact: Loren K. Tschetter, MD 605-328-8000
Avera McKennan Hospital and University Health Center
[Recruiting]
Sioux Falls, South Dakota, United States, 57105
Contact:Contact: Loren K. Tschetter, MD 605-328-8000
United States, Tennessee
Erlanger Cancer Center
[Recruiting]
Chattanooga, Tennessee, United States, 37403
Contact:Contact: Larry L. Schlabach, MD 423-266-4764
United States, Texas
St. Joseph Regional Cancer Center
[Recruiting]
Bryan, Texas, United States, 77802
Contact:Contact: Usha Venkatraj 979-774-0900
United States, Vermont
Fletcher Allen Health Care - University Health Center Campus
[Recruiting]
Burlington, Vermont, United States, 05401
Contact:Contact: Susan Burdette-Radoux, MD 802-847-3827
United States, Virginia
Danville Regional Medical Center
[Recruiting]
Danville, Virginia, United States, 24541
Contact:Contact: Timothy W. Brotherton, PhD, MD 434-793-0044
United States, Washington
St. Joseph Hospital Community Cancer Center
[Recruiting]
Bellingham, Washington, United States, 98225
Contact:Contact: Saul E. Rivkin, MD 206-386-2929
Group Health Central Hospital
[Recruiting]
Seattle, Washington, United States, 98104
Contact:Contact: Saul E. Rivkin, MD 206-386-2929
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
[Recruiting]
Seattle, Washington, United States, 98114
Contact:Contact: Saul E. Rivkin, MD 206-386-2929
University Cancer Center at University of Washington Medical Center
[Recruiting]
Seattle, Washington, United States, 98195
Contact:Contact: Saul E. Rivkin, MD 206-386-2929
Cancer Care Northwest - Spokane South
[Recruiting]
Spokane, Washington, United States, 99202
Contact:Contact: Saul E. Rivkin, MD 206-386-2929
Madigan Army Medical Center
[Recruiting]
Tacoma, Washington, United States, 98431
Contact:Contact: David E. McCune, MD 253-968-2504
United States, West Virginia
Mary Babb Randolph Cancer Center at West Virginia University Hospitals
[Recruiting]
Morgantown, West Virginia, United States, 26506
Contact:Contact: Jame Abraham, MD 304-293-4229
United States, Wisconsin
Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
[Recruiting]
La Crosse, Wisconsin, United States, 54601
Contact:Contact: Robert S. Witte, MD 608-782-7300
All Saints Cancer Center at All Saints Healthcare
[Recruiting]
Racine, Wisconsin, United States, 53405
Contact:Contact: Richard N. Odders, MD 262-687-5000
University of Wisconsin Cancer Center at Aspirus Wausau Hospital
[Recruiting]
Wausau, Wisconsin, United States, 54401
Contact:Contact: Umang Gautam, MD 715-847-2866
Canada, Alberta
Tom Baker Cancer Centre - Calgary
[Recruiting]
Calgary, Alberta, Canada, T2N 4N2
Contact:Contact: Barbara A. Walley, MD, FRCPC 403-944-1013
Canada, Ontario
Margaret and Charles Juravinski Cancer Centre
[Recruiting]
Hamilton, Ontario, Canada, L8V 5C2
Contact:Contact: Richard G. Tozer 905-387-9495ext64604
Trillium Health Centre - Mississauga
[Recruiting]
Mississauga, Ontario, Canada, L5B 1B8
Contact:Contact: John A.P. Gapski, MD 905-270-3842
Canada, Quebec
Hopital Charles Lemoyne
[Recruiting]
Greenfield Park, Quebec, Canada, J4V 2H1
Contact:Contact: Catherine Prady, MD 450-466-5000ext3376
Canada, Saskatchewan
Allan Blair Cancer Centre at Pasqua Hospital
[Recruiting]
Regina, Saskatchewan, Canada, S4T 7T1
Contact:Contact: Muhammad Salim, MD 306-766-2691
Switzerland
Ospedale Beata Vergine
[Recruiting]
Mendrisio, Switzerland, CH-6850
Contact:Contact: Olivia Pagani, MD 41-91-811-3667
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