ClinicalTrials.gov
History of Changes for Study: NCT00066703
Triptorelin With Either Exemestane or Tamoxifen in Treating Premenopausal Women With Hormone-Responsive Breast Cancer
Latest version (submitted December 14, 2023) on ClinicalTrials.gov
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Study Record Versions
Version A B Submitted Date Changes
1 June 23, 2005 None (earliest Version on record)
2 July 8, 2005 Study Status
3 August 2, 2005 Contacts/Locations and Study Status
4 August 16, 2005 Contacts/Locations, Study Status and Study Identification
5 August 22, 2005 Contacts/Locations and Study Status
6 August 29, 2005 Contacts/Locations and Study Status
7 September 6, 2005 Contacts/Locations and Study Status
8 September 8, 2005 Study Status
9 September 15, 2005 Contacts/Locations and Study Status
10 September 20, 2005 Contacts/Locations and Study Status
11 September 26, 2005 Contacts/Locations and Study Status
12 October 12, 2005 Contacts/Locations and Study Status
13 October 20, 2005 Contacts/Locations and Study Status
14 October 25, 2005 Contacts/Locations, Arms and Interventions and Study Status
15 November 3, 2005 Contacts/Locations, Conditions and Study Status
16 November 11, 2005 Contacts/Locations and Study Status
17 November 18, 2005 Contacts/Locations and Study Status
18 November 22, 2005 Contacts/Locations and Study Status
19 December 6, 2005 Contacts/Locations and Study Status
20 December 7, 2005 Contacts/Locations and Study Status
21 December 14, 2005 Contacts/Locations and Study Status
22 January 10, 2006 Contacts/Locations and Study Status
23 January 12, 2006 Contacts/Locations, Study Status, Eligibility and Study Description
24 January 16, 2006 Contacts/Locations and Study Status
25 January 24, 2006 Contacts/Locations and Study Status
26 February 6, 2006 Contacts/Locations and Study Status
27 February 9, 2006 Study Status and Contacts/Locations
28 March 8, 2006 Contacts/Locations and Study Status
29 March 9, 2006 Contacts/Locations and Study Status
30 March 15, 2006 Contacts/Locations and Study Status
31 March 21, 2006 Study Status and Study Identification
32 March 29, 2006 Contacts/Locations and Study Status
33 April 11, 2006 Study Status, Contacts/Locations and Eligibility
34 April 19, 2006 Contacts/Locations and Study Status
35 April 24, 2006 Contacts/Locations, Arms and Interventions and Study Status
36 May 10, 2006 Contacts/Locations and Study Status
37 May 16, 2006 Contacts/Locations and Study Status
38 May 30, 2006 Contacts/Locations and Study Status
39 June 7, 2006 Study Status
40 June 8, 2006 Contacts/Locations and Study Status
41 June 13, 2006 Contacts/Locations and Study Status
42 June 22, 2006 Contacts/Locations and Study Status
43 June 28, 2006 Contacts/Locations and Study Status
44 July 5, 2006 Contacts/Locations and Study Status
45 July 13, 2006 Contacts/Locations and Study Status
46 July 19, 2006 Contacts/Locations and Study Status
47 July 26, 2006 Contacts/Locations and Study Status
48 August 3, 2006 Study Status
49 August 10, 2006 Contacts/Locations and Study Status
50 August 16, 2006 Contacts/Locations and Study Status
51 August 24, 2006 Contacts/Locations and Study Status
52 August 29, 2006 Contacts/Locations and Study Status
53 September 6, 2006 Study Status
54 September 13, 2006 Contacts/Locations and Study Status
55 September 19, 2006 Contacts/Locations and Study Status
56 September 26, 2006 Contacts/Locations and Study Status
57 September 29, 2006 Study Status
58 October 12, 2006 Contacts/Locations and Study Status
59 October 18, 2006 Contacts/Locations and Study Status
60 October 25, 2006 Contacts/Locations, Eligibility and Study Status
61 November 8, 2006 Study Design, Conditions, Study Status, References and Study Identification
62 November 9, 2006 Contacts/Locations and Study Status
63 November 16, 2006 Contacts/Locations and Study Status
64 November 27, 2006 Contacts/Locations and Study Status
65 December 6, 2006 Contacts/Locations and Study Status
66 December 20, 2006 Contacts/Locations and Study Status
67 December 27, 2006 Contacts/Locations, Outcome Measures and Study Status
68 January 11, 2007 Study Status
69 January 16, 2007 Contacts/Locations and Study Status
70 January 25, 2007 Contacts/Locations, Study Status and Eligibility
71 January 30, 2007 Contacts/Locations and Study Status
72 February 8, 2007 Contacts/Locations and Study Status
73 February 20, 2007 Contacts/Locations, Study Status and Eligibility
74 March 5, 2007 Contacts/Locations and Study Status
75 March 7, 2007 Contacts/Locations and Study Status
76 March 13, 2007 Contacts/Locations and Study Status
77 March 20, 2007 Contacts/Locations and Study Status
78 March 27, 2007 Contacts/Locations and Study Status
79 April 9, 2007 Contacts/Locations and Study Status
80 April 11, 2007 Contacts/Locations and Study Status
81 April 18, 2007 Contacts/Locations and Study Status
82 April 25, 2007 Contacts/Locations and Study Status
83 May 2, 2007 Contacts/Locations and Study Status
84 May 3, 2007 Study Status and Contacts/Locations
85 May 8, 2007 Contacts/Locations and Study Status
86 May 16, 2007 Contacts/Locations and Study Status
87 May 23, 2007 Contacts/Locations and Study Status
88 June 4, 2007 Contacts/Locations and Study Status
89 June 6, 2007 Contacts/Locations and Study Status
90 June 13, 2007 Contacts/Locations and Study Status
91 June 20, 2007 Contacts/Locations and Study Status
92 June 25, 2007 Contacts/Locations and Study Status
93 July 3, 2007 Contacts/Locations and Study Status
94 July 10, 2007 Contacts/Locations and Study Status
95 July 17, 2007 Contacts/Locations and Study Status
96 July 30, 2007 Contacts/Locations and Study Status
97 August 8, 2007 Contacts/Locations and Study Status
98 August 21, 2007 Contacts/Locations and Study Status
99 August 24, 2007 Contacts/Locations and Study Status
100 August 28, 2007 Contacts/Locations and Study Status
101 September 5, 2007 Study Status and Contacts/Locations
102 September 10, 2007 Contacts/Locations and Study Status
103 September 18, 2007 Contacts/Locations and Study Status
104 September 20, 2007 Contacts/Locations and Study Status
105 September 25, 2007 Contacts/Locations and Study Status
106 September 27, 2007 Contacts/Locations and Study Status
107 October 1, 2007 Contacts/Locations and Study Status
108 October 5, 2007 Contacts/Locations and Study Status
109 October 13, 2007 Contacts/Locations and Study Status
110 October 17, 2007 Contacts/Locations and Study Status
111 October 19, 2007 Contacts/Locations and Study Status
112 October 25, 2007 Contacts/Locations, Arms and Interventions and Study Status
113 October 30, 2007 Contacts/Locations and Study Status
114 November 9, 2007 Study Status and Contacts/Locations
115 November 14, 2007 Contacts/Locations and Study Status
116 November 15, 2007 Contacts/Locations and Study Status
117 November 16, 2007 Contacts/Locations and Study Status
118 November 21, 2007 Contacts/Locations and Study Status
119 November 22, 2007 Contacts/Locations and Study Status
120 November 27, 2007 Contacts/Locations and Study Status
121 November 30, 2007 Contacts/Locations and Study Status
122 December 1, 2007 Contacts/Locations and Study Status
123 December 4, 2007 Recruitment Status, Study Status and Contacts/Locations
124 December 15, 2007 Arms and Interventions and Study Status
125 December 25, 2007 Study Status
126 April 30, 2008 Study Description and Study Status
127 May 23, 2008 Arms and Interventions and Study Status
128 July 23, 2008 Study Design and Study Status
129 August 12, 2008 Study Design, Study Description and Study Status
130 September 10, 2008 Recruitment Status, Study Status and Contacts/Locations
131 September 18, 2008 Recruitment Status, Study Status and Contacts/Locations
132 October 22, 2008 Study Status
133 November 20, 2008 Study Status and Contacts/Locations
134 November 25, 2008 Contacts/Locations and Study Status
135 November 28, 2008 Contacts/Locations and Study Status
136 December 3, 2008 Study Status and Contacts/Locations
137 December 4, 2008 Contacts/Locations and Study Status
138 December 6, 2008 Contacts/Locations and Study Status
139 December 9, 2008 Contacts/Locations and Study Status
140 December 10, 2008 Contacts/Locations and Study Status
141 December 16, 2008 Contacts/Locations and Study Status
142 December 17, 2008 Contacts/Locations and Study Status
143 December 19, 2008 Contacts/Locations and Study Status
144 December 24, 2008 Contacts/Locations and Study Status
145 December 25, 2008 Contacts/Locations and Study Status
146 December 31, 2008 Contacts/Locations and Study Status
147 January 6, 2009 Study Status and Contacts/Locations
148 January 7, 2009 Contacts/Locations and Study Status
149 January 9, 2009 Contacts/Locations and Study Status
150 January 10, 2009 Contacts/Locations and Study Status
151 January 14, 2009 Contacts/Locations and Study Status
152 January 15, 2009 Contacts/Locations and Study Status
153 January 16, 2009 Contacts/Locations and Study Status
154 January 21, 2009 Contacts/Locations and Study Status
155 January 22, 2009 Contacts/Locations and Study Status
156 January 28, 2009 Contacts/Locations and Study Status
157 January 29, 2009 Contacts/Locations and Study Status
158 January 30, 2009 Contacts/Locations and Study Status
159 February 3, 2009 Contacts/Locations and Study Status
160 February 7, 2009 Contacts/Locations and Study Status
161 February 10, 2009 Contacts/Locations and Study Status
162 February 11, 2009 Contacts/Locations and Study Status
163 February 12, 2009 Contacts/Locations and Study Status
164 February 14, 2009 Contacts/Locations and Study Status
165 February 17, 2009 Contacts/Locations and Study Status
166 February 19, 2009 Contacts/Locations and Study Status
167 February 21, 2009 Contacts/Locations and Study Status
168 February 25, 2009 Contacts/Locations and Study Status
169 February 27, 2009 Contacts/Locations and Study Status
170 March 5, 2009 Study Status and Contacts/Locations
171 March 7, 2009 Contacts/Locations and Study Status
172 March 10, 2009 Contacts/Locations and Study Status
173 March 11, 2009 Contacts/Locations and Study Status
174 March 13, 2009 Contacts/Locations and Study Status
175 March 17, 2009 Contacts/Locations and Study Status
176 March 18, 2009 Contacts/Locations and Study Status
177 March 19, 2009 Contacts/Locations and Study Status
178 March 21, 2009 Contacts/Locations and Study Status
179 March 27, 2009 Contacts/Locations and Study Status
180 March 31, 2009 Contacts/Locations and Study Status
181 April 3, 2009 Study Status and Contacts/Locations
182 April 6, 2009 Contacts/Locations and Study Status
183 April 7, 2009 Arms and Interventions and Study Status
184 April 8, 2009 Contacts/Locations and Study Status
185 April 9, 2009 Contacts/Locations and Study Status
186 April 10, 2009 Contacts/Locations and Study Status
187 April 11, 2009 Contacts/Locations and Study Status
188 April 14, 2009 Sponsor/Collaborators and Study Status
189 April 22, 2009 Contacts/Locations and Study Status
190 April 26, 2009 Contacts/Locations and Study Status
191 April 28, 2009 Contacts/Locations and Study Status
192 May 2, 2009 Study Status and Contacts/Locations
193 May 7, 2009 Contacts/Locations and Study Status
194 May 9, 2009 Contacts/Locations and Study Status
195 May 12, 2009 Contacts/Locations and Study Status
196 May 13, 2009 Contacts/Locations and Study Status
197 May 15, 2009 Contacts/Locations and Study Status
198 May 19, 2009 Contacts/Locations and Study Status
199 May 26, 2009 Contacts/Locations and Study Status
200 June 3, 2009 Contacts/Locations and Study Status
201 June 9, 2009 Contacts/Locations and Study Status
202 June 17, 2009 Contacts/Locations and Study Status
203 June 20, 2009 Contacts/Locations and Study Status
204 June 26, 2009 Contacts/Locations and Study Status
205 July 3, 2009 Study Status and Contacts/Locations
206 July 9, 2009 Contacts/Locations and Study Status
207 July 11, 2009 Contacts/Locations and Study Status
208 July 14, 2009 Contacts/Locations and Study Status
209 July 16, 2009 Contacts/Locations and Study Status
210 July 21, 2009 Contacts/Locations and Study Status
211 July 23, 2009 Contacts/Locations and Study Status
212 July 25, 2009 Contacts/Locations and Study Status
213 August 1, 2009 Contacts/Locations and Study Status
214 August 5, 2009 Study Status and Contacts/Locations
215 August 11, 2009 Contacts/Locations and Study Status
216 August 13, 2009 Contacts/Locations and Study Status
217 August 14, 2009 Contacts/Locations and Study Status
218 August 16, 2009 Contacts/Locations and Study Status
219 August 20, 2009 Contacts/Locations and Study Status
220 August 25, 2009 Contacts/Locations and Study Status
221 August 26, 2009 Contacts/Locations and Study Status
222 August 28, 2009 Contacts/Locations and Study Status
223 September 8, 2009 Study Status and Contacts/Locations
224 September 11, 2009 Contacts/Locations and Study Status
225 September 15, 2009 Contacts/Locations and Study Status
226 September 17, 2009 Contacts/Locations and Study Status
227 September 23, 2009 Contacts/Locations and Study Status
228 September 29, 2009 Contacts/Locations and Study Status
229 September 30, 2009 Contacts/Locations and Study Status
230 October 1, 2009 Contacts/Locations and Study Status
231 October 6, 2009 Study Status and Contacts/Locations
232 October 7, 2009 Contacts/Locations and Study Status
233 October 13, 2009 Contacts/Locations and Study Status
234 October 15, 2009 Contacts/Locations and Study Status
235 October 16, 2009 Contacts/Locations and Study Status
236 October 20, 2009 Contacts/Locations and Study Status
237 October 21, 2009 Contacts/Locations and Study Status
238 October 29, 2009 Contacts/Locations and Study Status
239 October 30, 2009 Contacts/Locations and Study Status
240 November 3, 2009 Contacts/Locations and Study Status
241 November 4, 2009 Study Status and Contacts/Locations
242 November 7, 2009 Contacts/Locations and Study Status
243 November 10, 2009 Contacts/Locations and Study Status
244 November 12, 2009 Contacts/Locations and Study Status
245 November 18, 2009 Contacts/Locations and Study Status
246 December 2, 2009 Study Status and Contacts/Locations
247 December 5, 2009 Contacts/Locations and Study Status
248 December 11, 2009 Contacts/Locations and Study Status
249 December 15, 2009 Contacts/Locations and Study Status
250 December 17, 2009 Contacts/Locations and Study Status
251 December 22, 2009 Contacts/Locations and Study Status
252 December 23, 2009 Contacts/Locations and Study Status
253 January 7, 2010 Study Status and Contacts/Locations
254 January 12, 2010 Contacts/Locations and Study Status
255 January 15, 2010 Contacts/Locations and Study Status
256 January 22, 2010 Contacts/Locations and Study Status
257 January 23, 2010 Contacts/Locations and Study Status
258 January 26, 2010 Contacts/Locations and Study Status
259 January 27, 2010 Contacts/Locations and Study Status
260 January 28, 2010 Contacts/Locations and Study Status
261 January 29, 2010 Contacts/Locations and Study Status
262 February 1, 2010 Contacts/Locations and Study Status
263 February 2, 2010 Contacts/Locations and Study Status
264 February 3, 2010 Study Status
265 February 4, 2010 Contacts/Locations and Study Status
266 February 6, 2010 Contacts/Locations and Study Status
267 February 11, 2010 Contacts/Locations and Study Status
268 February 16, 2010 Contacts/Locations and Study Status
269 February 18, 2010 Contacts/Locations and Study Status
270 February 19, 2010 Contacts/Locations and Study Status
271 February 20, 2010 Contacts/Locations and Study Status
272 February 23, 2010 Contacts/Locations and Study Status
273 February 25, 2010 Contacts/Locations and Study Status
274 February 26, 2010 Contacts/Locations and Study Status
275 March 2, 2010 Contacts/Locations and Study Status
276 March 3, 2010 Study Status and Contacts/Locations
277 March 4, 2010 Contacts/Locations and Study Status
278 March 9, 2010 Contacts/Locations and Study Status
279 March 10, 2010 Contacts/Locations and Study Status
280 March 11, 2010 Contacts/Locations and Study Status
281 March 12, 2010 Contacts/Locations and Study Status
282 March 16, 2010 Contacts/Locations and Study Status
283 March 18, 2010 Contacts/Locations and Study Status
284 March 22, 2010 Contacts/Locations and Study Status
285 March 24, 2010 Contacts/Locations and Study Status
286 March 26, 2010 Contacts/Locations and Study Status
287 March 27, 2010 Contacts/Locations and Study Status
288 March 30, 2010 Contacts/Locations and Study Status
289 April 1, 2010 Contacts/Locations and Study Status
290 April 6, 2010 Study Status and Contacts/Locations
291 April 7, 2010 Contacts/Locations and Study Status
292 April 8, 2010 Contacts/Locations and Study Status
293 April 13, 2010 Contacts/Locations and Study Status
294 April 15, 2010 Contacts/Locations and Study Status
295 April 17, 2010 Contacts/Locations and Study Status
296 April 21, 2010 Contacts/Locations and Study Status
297 May 8, 2010 Study Status and Contacts/Locations
298 May 11, 2010 Contacts/Locations and Study Status
299 May 12, 2010 Contacts/Locations and Study Status
300 May 15, 2010 Contacts/Locations and Study Status
301 May 18, 2010 Contacts/Locations and Study Status
302 May 27, 2010 Contacts/Locations and Study Status
303 May 28, 2010 Contacts/Locations and Study Status
304 June 5, 2010 Study Status and Contacts/Locations
305 June 8, 2010 Contacts/Locations and Study Status
306 June 9, 2010 Contacts/Locations and Study Status
307 June 11, 2010 Contacts/Locations and Study Status
308 June 19, 2010 Contacts/Locations and Study Status
309 June 22, 2010 Contacts/Locations and Study Status
310 June 24, 2010 Contacts/Locations and Study Status
311 June 25, 2010 Contacts/Locations and Study Status
312 June 26, 2010 Contacts/Locations and Study Status
313 June 29, 2010 Contacts/Locations and Study Status
314 July 2, 2010 Study Status and Contacts/Locations
315 July 3, 2010 Contacts/Locations and Study Status
316 July 13, 2010 Contacts/Locations and Study Status
317 July 14, 2010 Contacts/Locations and Study Status
318 July 17, 2010 Contacts/Locations and Study Status
319 July 21, 2010 Contacts/Locations and Study Status
320 July 28, 2010 Contacts/Locations, Sponsor/Collaborators and Study Status
321 August 3, 2010 Study Status and Contacts/Locations
322 August 5, 2010 Contacts/Locations and Study Status
323 August 6, 2010 Contacts/Locations and Study Status
324 August 10, 2010 Contacts/Locations and Study Status
325 August 11, 2010 Contacts/Locations and Study Status
326 August 14, 2010 Contacts/Locations and Study Status
327 August 18, 2010 Contacts/Locations and Study Status
328 August 20, 2010 Contacts/Locations and Study Status
329 August 24, 2010 Contacts/Locations and Study Status
330 August 29, 2010 Contacts/Locations and Study Status
331 September 10, 2010 Contacts/Locations and Study Status
332 September 17, 2010 Conditions and Study Status
333 September 18, 2010 Contacts/Locations and Study Status
334 September 24, 2010 Contacts/Locations and Study Status
335 September 25, 2010 Contacts/Locations and Study Status
336 September 28, 2010 Contacts/Locations and Study Status
337 October 6, 2010 Study Status and Contacts/Locations
338 October 8, 2010 Contacts/Locations and Study Status
339 October 12, 2010 Contacts/Locations and Study Status
340 October 13, 2010 Contacts/Locations and Study Status
341 October 16, 2010 Contacts/Locations and Study Status
342 October 19, 2010 Contacts/Locations and Study Status
343 October 20, 2010 Contacts/Locations and Study Status
344 October 21, 2010 Contacts/Locations and Study Status
345 October 23, 2010 Contacts/Locations and Study Status
346 October 26, 2010 Contacts/Locations and Study Status
347 October 28, 2010 Contacts/Locations and Study Status
348 October 29, 2010 Contacts/Locations and Study Status
349 October 30, 2010 Contacts/Locations and Study Status
350 November 2, 2010 Contacts/Locations and Study Status
351 November 3, 2010 Contacts/Locations and Study Status
352 November 5, 2010 Contacts/Locations and Study Status
353 November 9, 2010 Contacts/Locations and Study Status
354 November 10, 2010 Contacts/Locations and Study Status
355 November 12, 2010 Contacts/Locations and Study Status
356 November 18, 2010 Contacts/Locations and Study Status
357 November 20, 2010 Contacts/Locations and Study Status
358 November 23, 2010 Contacts/Locations and Study Status
359 December 1, 2010 Contacts/Locations and Study Status
360 December 4, 2010 Study Status and Contacts/Locations
361 December 7, 2010 Contacts/Locations and Study Status
362 December 8, 2010 Contacts/Locations and Study Status
363 December 15, 2010 Contacts/Locations and Study Status
364 December 16, 2010 Contacts/Locations and Study Status
365 December 21, 2010 Contacts/Locations and Study Status
366 December 22, 2010 Contacts/Locations and Study Status
367 December 24, 2010 Contacts/Locations and Study Status
368 January 7, 2011 Study Status
369 January 8, 2011 Contacts/Locations and Study Status
370 January 20, 2011 Contacts/Locations and Study Status
371 January 25, 2011 Contacts/Locations and Study Status
372 January 26, 2011 Contacts/Locations and Study Status
373 January 27, 2011 Contacts/Locations and Study Status
374 February 5, 2011 Study Status and Contacts/Locations
375 February 10, 2011 Contacts/Locations and Study Status
376 February 15, 2011 Contacts/Locations and Study Status
377 February 22, 2011 Contacts/Locations and Study Status
378 February 25, 2011 Contacts/Locations and Study Status
379 March 1, 2011 Contacts/Locations and Study Status
380 March 3, 2011 Study Status and Contacts/Locations
381 March 4, 2011 Contacts/Locations and Study Status
382 March 9, 2011 Contacts/Locations and Study Status
383 March 11, 2011 Contacts/Locations and Study Status
384 March 16, 2011 Recruitment Status, Study Status and Contacts/Locations
385 April 5, 2011 Study Status
386 February 8, 2012 Outcome Measures, Sponsor/Collaborators, Study Status, Study Identification, Contacts/Locations, Study Design, Study Description and Oversight
387 July 26, 2012 Study Design, Study Status and Study Identification
388 May 15, 2013 Contacts/Locations, Study Identification, Arms and Interventions, Outcome Measures, Sponsor/Collaborators, Study Status, Study Design, Conditions, Study Description, References, Eligibility and Oversight
389 November 6, 2013 Contacts/Locations, Study Identification, Arms and Interventions, Outcome Measures, Sponsor/Collaborators, Study Status, Study Design, Conditions, Study Description, References, Eligibility and Oversight
390 May 16, 2014 Study Status and Eligibility
391 June 3, 2014 Contacts/Locations and Study Status
392 July 10, 2014 Contacts/Locations and Study Status
393 March 24, 2015 Study Status and Outcome Measures
394 March 7, 2016 Study Status, Arms and Interventions, Outcome Measures, Study Identification, References, Results, Eligibility, Study Description and Oversight
395 September 26, 2016 Study Identification and Study Status
396 December 22, 2017 Contacts/Locations, Study Status and Outcome Measures
397 March 15, 2019 Outcome Measures and Study Status
398 March 9, 2020 Outcome Measures and Study Status
399 March 18, 2020 Study Status
400 August 4, 2020 Study Status
401 February 12, 2021 Study Status
402 November 15, 2022 Study Status and Study Identification
403 December 14, 2023 More Information, Study Status and References
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Study NCT00066703
Submitted Date:  July 13, 2006 (v45)
Open or close this module Study Identification
Unique Protocol ID: CDR0000316458
Brief Title: Triptorelin With Either Exemestane or Tamoxifen in Treating Premenopausal Women With Hormone-Responsive Breast Cancer
Official Title: Phase III Randomized Study of Triptorelin and Exemestane Versus Triptorelin and Tamoxifen in Premenopausal Women With Endocrine-Responsive Breast Cancer
Secondary IDs: IBCSG-25-02
BIG-3-02
NABCI-IBCSG-25-02
EU-20347
EUDRACT-2004-000168-28
Open or close this module Study Status
Record Verification: July 2006
Overall Status: Recruiting
Study Start:
Primary Completion:
Study Completion:
First Submitted: August 6, 2003
First Submitted that
Met QC Criteria:		 August 6, 2003
First Posted: August 7, 2003 [Estimate]
Last Update Submitted that
Met QC Criteria:		 July 13, 2006
Last Update Posted: July 14, 2006 [Estimate]
Open or close this module Sponsor/Collaborators
Sponsor: ETOP IBCSG Partners Foundation
Responsible Party:
Collaborators: National Cancer Institute (NCI)
Breast International Group
Open or close this module Oversight
U.S. FDA-regulated Drug:
U.S. FDA-regulated Device:
Data Monitoring:
Open or close this module Study Description
Brief Summary:

RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using triptorelin, exemestane, and tamoxifen may fight breast cancer by blocking the uptake of estrogen. It is not yet known whether giving triptorelin together with exemestane is more effective than triptorelin and tamoxifen in treating hormone-responsive breast cancer.

PURPOSE: This randomized phase III trial is studying triptorelin and exemestane to see how well they work compared to triptorelin and tamoxifen in treating premenopausal women with hormone-responsive breast cancer.
Detailed Description:

OBJECTIVES:

  • Compare the disease-free and overall survival of premenopausal women with endocrine-responsive breast cancer when treated with triptorelin and exemestane vs triptorelin and tamoxifen.
  • Compare the quality of life, including late side effects of early menopause, of patients treated with these regimens.
  • Compare the sites of first treatment failure in patients treated with these regimens.
  • Compare the incidence of second (non-breast) malignancies in patients treated with these regimens.

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to participating center, concurrent adjuvant chemotherapy (yes vs no), and number of positive axillary and/or internal mammary lymph nodes (0 vs 1 or more). Patients are randomized to 1 of 2 treatment arms.

  • Arm I: Patients receive triptorelin intramuscularly on day 1 every 28 days. Patients in the adjuvant chemotherapy stratum receive chemotherapy concurrently with triptorelin for at least 2 months (if anthracycline is included) or at least 4 months (if no anthracycline is included). Beginning after the completion of chemotherapy or approximately 6-8 weeks after the initiation of triptorelin, patients receive oral tamoxifen daily.
  • Arm II: Patients receive triptorelin as in arm I. Beginning after the completion of adjuvant chemotherapy or approximately 6-8 weeks after the initiation of triptorelin, patients also receive oral exemestane daily.

In both arms, treatment continues for 5 years in the absence of disease progression or unacceptable toxicity.

Quality of life is assessed at baseline, every 6 months for 2 years, and annually for 3 years.

Patients are followed every 3 months for 1 year, every 6 months for 5 years, and then annually thereafter.

PROJECTED ACCRUAL: A total of 1,845 patients will be accrued for this study within 4.5 years.
Open or close this module Conditions
Conditions: Stage I Breast Cancer
Stage II Breast Cancer
Stage IIIA Breast Cancer
Keywords:
Open or close this module Study Design
Study Type: Interventional
Primary Purpose: Treatment
Study Phase: Phase 3
Interventional Study Model:
Number of Arms:
Masking: (masked roles unspecified)
Enrollment:
Open or close this module Arms and Interventions
Intervention Details:
Drug: exemestane
Drug: tamoxifen citrate
Drug: triptorelin
Procedure: adjuvant therapy
Procedure: antiestrogen therapy
Procedure: antiprogestational therapy
Procedure: aromatase inhibition
Procedure: endocrine therapy
Procedure: hormone therapy
Procedure: releasing hormone agonist therapy
Open or close this module Outcome Measures
Open or close this module Eligibility
Minimum Age: 0 Years
Maximum Age:
Sex: All
Gender Based:
Accepts Healthy Volunteers: No
Criteria:

DISEASE CHARACTERISTICS:

  • Histologically confirmed breast cancer
  • Completely resected disease
  • No clinically detectable residual loco-regional axillary disease
  • Prior surgery for primary breast cancer of 1 of the following types:
  • Total mastectomy with or without adjuvant radiotherapy
  • Breast-conserving procedure (e.g., lumpectomy, quadrantectomy, or partial mastectomy with margins negative* for invasive disease and ductal carcinoma in situ) with planned radiotherapy NOTE: *If all other margins are clear a positive posterior (deep) margin is permitted, provided the excision was performed down to the pectoral fascia and all tumor has been removed OR a positive anterior (superficial; abutting skin) margin is allowed provided all tumor was removed
  • Tumor confined to the breast and axillary nodes
  • Tumor detected in internal mammary chain nodes by sentinel node procedure and is not enlarged is allowed
  • Axillary lymph node dissection or a negative axillary sentinel node biopsy required
  • Patients with negative or microscopically positive axillary sentinel nodes are eligible
  • Positive sentinel nodes must have either axillary dissection or radiation of axillary nodes
  • No distant metastases
  • No locally advanced inoperable breast cancer, including any of the following:
  • Inflammatory breast cancer
  • Supraclavicular node involvement
  • Enlarged internal mammary nodes (unless pathologically negative)
  • Bilateral synchronous invasive breast cancer allowed if disease meets all other eligibility criteria
  • No prior ipsilateral or contralateral invasive breast cancer
  • Hormone receptor status:
  • Estrogen and/or progesterone receptor positive
  • At least 10% of the tumor cells positive by immunohistochemistry
  • If > 1 breast tumor, each tumor must be hormone receptor positive

PATIENT CHARACTERISTICS:

Age

  • Premenopausal

Sex

  • Female

Menopausal status

  • Premenopausal
  • Estradiol in the premenopausal range after prior surgery OR meets the following criteria:
  • Menstruating regularly for the past 6 months
  • Has not used any form of hormonal treatment (including hormonal contraception) within the past 6 months

Performance status

  • Not specified

Life expectancy

  • Not specified

Hematopoietic

  • Not specified

Hepatic

  • No systemic hepatic disease that would preclude prolonged follow-up

Renal

  • No systemic renal disease that would preclude prolonged follow-up

Cardiovascular

  • No systemic cardiovascular disease that would preclude prolonged follow-up
  • No prior thrombosis (e.g., deep vein thrombosis) and/or embolism unless patient is medically suitable

Pulmonary

  • No systemic pulmonary disease that would preclude prolonged follow-up

Other

  • Not pregnant or nursing
  • Fertile patients must use effective nonhormonal contraception
  • No history of noncompliance to medical regimens
  • No other nonmalignant systemic disease that would preclude prolonged follow-up
  • No other malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer, nonbreast carcinoma in situ, contralateral or ipsilateral carcinoma in situ of the breast, or other nonrecurrent invasive nonbreast malignancy, including any of the following:
  • Stage I papillary thyroid cancer
  • Stage IA carcinoma of the cervix
  • Stage IA or B endometrioid endometrial cancer
  • Borderline or stage I ovarian cancer
  • No psychiatric, addictive, or other disorder that would preclude study compliance

PRIOR CONCURRENT THERAPY:

Biologic therapy

  • Prior or concurrent neoadjuvant or adjuvant trastuzumab allowed

Chemotherapy

  • No prior neoadjuvant or adjuvant chemotherapy
  • Prior or concurrent neoadjuvant or adjuvant trastuzumab allowed

Endocrine therapy

  • No prior tamoxifen, other selective estrogen-receptor modulators (SERMs) (e.g., raloxifene), or hormone replacement therapy for more than 1 year before breast cancer diagnosis
  • No prior neoadjuvant or adjuvant endocrine therapy since diagnosis of breast cancer
  • No concurrent oral or transdermal hormonal therapy
  • No other concurrent estrogen, progesterone, or androgens
  • No other concurrent aromatase inhibitors
  • No concurrent hormone replacement therapy
  • No concurrent oral or other hormonal contraceptives (i.e., implants or depot injections)
  • No concurrent SERMs (e.g., raloxifene)

Radiotherapy

  • See Disease Characteristics
  • No prior ovarian radiotherapy

Surgery

  • See Disease Characteristics
  • No prior bilateral oophorectomy

Other

  • No concurrent bisphosphonates, except in the following cases:
  • Bone density is at least 1.5 standard deviations below the young adult normal mean
  • Participation in a randomized clinical study testing bisphosphonates in the adjuvant breast cancer setting
  • No other concurrent investigational agents
Open or close this module Contacts/Locations
Study Officials: Olivia Pagani, MD
Study Chair
Ospedale Beata Vergine
Locations: United States, Arkansas
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
[Recruiting]
Little Rock, Arkansas, United States, 72205
Contact:Contact: Laura F. Hutchins, MD 501-686-6000
United States, California
Providence Saint Joseph Medical Center - Burbank
[Recruiting]
Burbank, California, United States, 91505
Contact:Contact: Clinical Trials Office - Providence Saint Joseph Medical Cente 818-847-3220
Moores UCSD Cancer Center
[Recruiting]
La Jolla, California, United States, 92093-0658
Contact:Contact: Clinical Trials Office - Rebecca and John Moores UCSD Cancer C 858-822-5354 cancercto@ucsd.edu
USC/Norris Comprehensive Cancer Center and Hospital
[Recruiting]
Los Angeles, California, United States, 90089-9181
Contact:Contact: Clinical Trials Office - USC/Norris Comprehensive Cancer Cente 323-865-0451
Sutter Cancer Center at Roseville Medical Center
[Recruiting]
Roseville, California, United States, 95661
Contact:Contact: Clinical Trials Office - Sutter Cancer Center 916-454-6595
Sutter Cancer Center
[Recruiting]
Sacramento, California, United States, 95816
Contact:Contact: Clinical Trial Office - Sutter Cancer Center 916-454-6595
San Francisco General Hospital Medical Center
[Recruiting]
San Francisco, California, United States, 94110
Contact:Contact: Hope S. Rugo, MD 415-353-7428
United States, Colorado
University of Colorado Cancer Center at University of Colorado Health Sciences Center
[Recruiting]
Aurora, Colorado, United States, 80045
Contact:Contact: Clinical Trials Office - University of Colorado Cancer Center 720-848-0650
United States, Florida
University of Florida Shands Cancer Center
[Recruiting]
Gainesville, Florida, United States, 32610-0232
Contact:Contact: Clinical Trials Office - University of Florida Shands Cancer C 888-254-7581
Mayo Clinic - Jacksonville
[Recruiting]
Jacksonville, Florida, United States, 32224
Contact:Contact: Clinical Trials Office - Mayo Clinic - Jacksonville 800-664-4542 clinicaltrials@mayo.edu
University of Miami Sylvester Comprehensive Cancer Center
[Recruiting]
Miami, Florida, United States, 33136
Contact:Contact: University of Miami Sylvester Comprehensive Cancer Center Clin 866-574-5124 Sylvester@emergingmed.com
United States, Idaho
St. Luke's Mountain States Tumor Institute - Boise
[Recruiting]
Boise, Idaho, United States, 83712
Contact:Contact: Theodore A. Walters, MD 208-381-2711
United States, Illinois
John H. Stroger, Jr. Hospital of Cook County
[Recruiting]
Chicago, Illinois, United States, 60612-3785
Contact:Contact: Keith A. Dookeran, MD 312-864-5204
University of Chicago Cancer Research Center
[Recruiting]
Chicago, Illinois, United States, 60637-1470
Contact:Contact: Clinical Trials Office - University of Chicago Cancer Research 773-702-8992
Evanston Northwestern Health Care - Evanston Hospital
[Recruiting]
Evanston, Illinois, United States, 60201-1781
Contact:Contact: Clinical Trials Office - Evanston Northwestern Health Care - E 847-570-1381
Hematology/Oncology of the North Shore at Gross Point Medical Center
[Recruiting]
Skokie, Illinois, United States, 60076
Contact:Contact: Marlon B. Kleinman 847-675-3900
United States, Indiana
Fort Wayne Medical Oncology and Hematology
[Recruiting]
Fort Wayne, Indiana, United States, 46815
Contact:Contact: Sreenivasa R. Nattam, MD 260-484-8830
CCOP - Northern Indiana CR Consortium
[Recruiting]
South Bend, Indiana, United States, 46601
Contact:Contact: Rafat H. Ansari, MD, FACP 574-234-5123
United States, Iowa
Hematology Oncology Associates of the Quad Cities
[Recruiting]
Bettendorf, Iowa, United States, 52722
Contact:Contact: Shobha R. Chitneni 563-355-7733
Siouxland Hematology-Oncology Associates, LLP
[Recruiting]
Sioux City, Iowa, United States, 51101
Contact:Contact: Donald B. Wender, MD, PhD 712-252-9326
Cedar Valley Medical Specialists, P.C. - West Ridgeway Avenue
[Recruiting]
Waterloo, Iowa, United States, 50702
Contact:Contact: Mohammed T. Masri, MD 319-272-2070
United States, Kansas
Cancer Center of Kansas, PA - Chanute
[Recruiting]
Chanute, Kansas, United States, 66720
Contact:Contact: Shaker R. Dakhil, MD, FACP 316-262-4467
Cancer Center of Kansas, PA - Dodge City
[Recruiting]
Dodge City, Kansas, United States, 67801
Contact:Contact: Shaker R. Dakhil, MD, FACP 316-262-4467
Cancer Center of Kansas, PA - Kingman
[Recruiting]
Kingman, Kansas, United States, 67068
Contact:Contact: Shaker R. Dakhil, MD, FACP 316-262-4467
Southwest Medical Center
[Recruiting]
Liberal, Kansas, United States, 67901
Contact:Contact: Shaker R. Dakhil, MD, FACP 316-262-4467
Cancer Center of Kansas, PA - Newton
[Recruiting]
Newton, Kansas, United States, 67114
Contact:Contact: Shaker R. Dakhil, MD, FACP 316-262-4467
Cancer Center of Kansas, PA - Salina
[Recruiting]
Salina, Kansas, United States, 67042
Contact:Contact: Shaker R. Dakhil, MD, FACP 316-262-4467
Stormont-Vail Cancer Center
[Recruiting]
Topeka, Kansas, United States, 66604
Contact:Contact: Stanley J. Vogel, MD 785-354-0544
Cancer Center of Kansas, PA - Wellington
[Recruiting]
Wellington, Kansas, United States, 67152
Contact:Contact: Shaker R. Dakhil, MD, FACP 316-262-4467
Associates in Womens Health, PA - North Review
[Recruiting]
Wichita, Kansas, United States, 67203
Contact:Contact: Shaker R. Dakhil, MD, FACP 316-262-4467
Cancer Center of Kansas, PA - Medical Arts Tower
[Recruiting]
Wichita, Kansas, United States, 67208
Contact:Contact: Shaker R. Dakhil, MD, FACP 316-262-4467
Cancer Center of Kansas, PA - Wichita
[Recruiting]
Wichita, Kansas, United States, 67214
Contact:Contact: Shaker R. Dakhil, MD, FACP 316-262-4467
CCOP - Wichita
[Recruiting]
Wichita, Kansas, United States, 67214
Contact:Contact: Shaker R. Dakhil, MD, FACP 316-262-4467
Via Christi Cancer Center at Via Christi Regional Medical Center
[Recruiting]
Wichita, Kansas, United States, 67214
Contact:Contact: Shaker R. Dakhil, MD, FACP 316-262-4467
Cancer Center of Kansas, PA - Winfield
[Recruiting]
Winfield, Kansas, United States, 67156
Contact:Contact: Shaker R. Dakhil, MD, FACP 316-262-4467
United States, Maine
MaineGeneral Medical Center - Waterville Campus
[Recruiting]
Waterville, Maine, United States, 04901
Contact:Contact: Clinical Trials Office - MaineGeneral Medical Center - Watervi 207-872-1792
United States, Maryland
Greenebaum Cancer Center at University of Maryland Medical Center
[Recruiting]
Baltimore, Maryland, United States, 21201
Contact:Contact: Clinical Trials Office - Greenebaum Cancer Center 800-888-8823
Suburban Hospital
[Recruiting]
Bethesda, Maryland, United States, 20814
Contact:Contact: Carolyn B. Hendricks, MD 301-897-1503
Frederick Memorial Hospital Regional Cancer Therapy Center
[Recruiting]
Frederick, Maryland, United States, 21701
Contact:Contact: Elhamy Eskander, MD, FACP 301-662-8477
United States, Massachusetts
Tufts-NEMC Cancer Center
[Recruiting]
Boston, Massachusetts, United States, 02111
Contact:Contact: John K. Erban, MD 617-636-5147
Massachusetts General Hospital Cancer Center
[Recruiting]
Boston, Massachusetts, United States, 02114
Contact:Contact: Clinical Trials Office - Massachusetts General Hospital Cancer 877-726-5130
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
[Recruiting]
Boston, Massachusetts, United States, 02115
Contact:Contact: Clinical Trials Office - Dana-Farber/Harvard Cancer Center 617-582-8480
Faulkner Hospital
[Recruiting]
Boston, Massachusetts, United States, 02130
Contact:Contact: Harold J. Burstein, MD, PhD 617-632-3800
Beth Israel Deaconess Medical Center
[Recruiting]
Boston, Massachusetts, United States, 02215
Contact:Contact: Clinical Trials Office - Beth Israel Deaconess Medical Center 617-667-9925
Bethke Cancer Center at Emerson Hospital
[Recruiting]
Concord, Massachusetts, United States, 01742
Contact:Contact: Harold J. Burstein, MD, PhD 617-632-3800
Addison Gilbert Hospital
[Recruiting]
Gloucester, Massachusetts, United States, 01930
Contact:Contact: Angus P. McIntyre, MD 978-281-6460
Cape Cod Hospital
[Recruiting]
Hyannis, Massachusetts, United States, 02601
Contact:Contact: David R. Lovett 508-771-1800
NSMC Cancer Center - Peabody
[Recruiting]
Peabody, Massachusetts, United States, 01960
Contact:Contact: Karen Krag, MD 978-977-3434
United States, Michigan
William Beaumont Hospital - Royal Oak Campus
[Recruiting]
Royal Oak, Michigan, United States, 48073
Contact:Contact: Cancer Clinical Trials Office 248-551-7695
United States, Minnesota
Fairview Ridges Hospital
[Recruiting]
Burnsville, Minnesota, United States, 55337
Contact:Contact: Patrick J. Flynn, MD 612-863-8585
Mercy and Unity Cancer Center at Mercy Hospital
[Recruiting]
Coon Rapids, Minnesota, United States, 55433
Contact:Contact: Patrick J. Flynn, MD 612-863-8585
Fairview Southdale Hospital
[Recruiting]
Edina, Minnesota, United States, 55435
Contact:Contact: Clinical Trials Office - Fairview Southdale Hospital 612-625-3650
Mercy and Unity Cancer Center at Unity Hospital
[Recruiting]
Fridley, Minnesota, United States, 55432
Contact:Contact: Patrick J. Flynn, MD 612-863-8585
Virginia Piper Cancer Institute at Abbott-Northwestern Hospital
[Recruiting]
Minneapolis, Minnesota, United States, 55407
Contact:Contact: Clinical Trials Office - Virginia Piper Cancer Institute at Ab 612-863-5654
Hubert H. Humphrey Cancer Center at North Memorial Medical Center
[Recruiting]
Robbinsdale, Minnesota, United States, 55422-2900
Contact:Contact: Clinical Trials Office - Hubert H. Humphrey Cancer Center 763-520-1893
Mayo Clinic Cancer Center
[Recruiting]
Rochester, Minnesota, United States, 55905
Contact:Contact: Clinical Trials Office - Mayo Clinic Cancer Center 507-538-7623
CCOP - Metro-Minnesota
[Recruiting]
Saint Louis Park, Minnesota, United States, 55416
Contact:Contact: Patrick J. Flynn, MD 612-863-8585
Park Nicollet Health Services
[Recruiting]
St. Louis Park, Minnesota, United States, 55416
Contact:Contact: Patrick J. Flynn, MD 612-863-8585
United Hospital
[Recruiting]
St. Paul, Minnesota, United States, 55102
Contact:Contact: Patrick J. Flynn, MD 612-863-8585
Ridgeview Medical Center
[Recruiting]
Waconia, Minnesota, United States, 55387
Contact:Contact: Patrick J. Flynn, MD 612-863-8585
United States, Missouri
CCOP - Kansas City
[Recruiting]
Kansas City, Missouri, United States, 64131
Contact:Contact: William T. Stephenson, MD 816-823-0555
Saint Louis University Cancer Center
[Recruiting]
Saint Louis, Missouri, United States, 63110
Contact:Contact: Clinical Trials Office - St. Louis University Cancer Center 314-977-4440
St. John's Regional Health Center
[Recruiting]
Springfield, Missouri, United States, 65804
Contact:Contact: John W. Goodwin, MD 417-889-8099
Hulston Cancer Center at Cox Medical Center South
[Recruiting]
Springfield, Missouri, United States, 65807
Contact:Contact: John W. Goodwin, MD 417-889-8099
Siteman Cancer Center at Barnes-Jewish Hospital
[Recruiting]
St Louis, Missouri, United States, 63110
Contact:Contact: Matthew J. Ellis, MD, PhD, FRCP 314-747-7222
United States, Montana
CCOP - Montana Cancer Consortium
[Recruiting]
Billings, Montana, United States, 59101
Contact:Contact: Benjamin T. Marchello 406-259-2245
United States, New Jersey
CCOP - Northern New Jersey
[Recruiting]
Hackensack, New Jersey, United States, 07601
Contact:Contact: Norman G. Rosenblum, MD, PhD 201-996-5917
Fox Chase Virtua Health Cancer Program - Marlton
[Recruiting]
Marlton, New Jersey, United States, 08053
Contact:Contact: Clinical Trials Office - Fox Chase Virtua Health Cancer Progra 888-847-8823
Overlook Hospital
[Recruiting]
Summit, New Jersey, United States, 07902
Contact:Contact: Daniel J. Moriarty, MD 908-608-0078
South Jersey Healthcare Regional Cancer Center
[Recruiting]
Vineland, New Jersey, United States, 08360
Contact:Contact: Clinical Trials Office - South Jersey Healthcare Regional Canc 856-641-7933
United States, New York
Albert Einstein Cancer Center at Albert Einstein College of Medicine
[Recruiting]
Bronx, New York, United States, 10461
Contact:Contact: Clinical Trials Office - Albert Einstein Cancer Center 718-430-2302 aecc@aecom.yu.edu
United States, North Carolina
Randolph Hospital
[Recruiting]
Asheboro, North Carolina, United States, 27203-5400
Contact:Contact: Clinical Trails Office - Randolph Hospital 336-832-0821
Hope A Women's Cancer Center
[Recruiting]
Asheville, North Carolina, United States, 28801
Contact:Contact: David J. Hetzel, MD 828-670-8403
Mission Hospitals - Memorial Campus
[Recruiting]
Asheville, North Carolina, United States, 28801
Contact:Contact: Clinical Trials Office - Mission Hospitals - Memorial Campus 828-213-4150
Presbyterian Cancer Center at Presbyterian Hospital
[Recruiting]
Charlotte, North Carolina, United States, 28233-3549
Contact:Contact: Clinical Trials Office - Presbyterian Cancer Center 704-384-5369
Wayne Memorial Hospital, Incorporated
[Recruiting]
Goldsboro, North Carolina, United States, 27534
Contact:Contact: James N. Atkins, MD 919-580-0000
Moses Cone Regional Cancer Center at Wesley Long Community Hospital
[Recruiting]
Greensboro, North Carolina, United States, 27403-1199
Contact:Contact: Clinical Trials Office - Moses Cone Regional Cancer Center 336-832-0821
Pardee Memorial Hospital
[Recruiting]
Hendersonville, North Carolina, United States, 28791
Contact:Contact: James E. Radford, MD 828-692-8045
Lenoir Memorial Cancer Center
[Recruiting]
Kinston, North Carolina, United States, 28501
Contact:Contact: Peter R. Watson, MD 252-522-7600
Annie Penn Cancer Center
[Recruiting]
Reidsville, North Carolina, United States, 27320
Contact:Contact: John E. Feldmann 336-951-4584
Forsyth Regional Cancer Center at Forsyth Medical Center
[Recruiting]
Winston-Salem, North Carolina, United States, 27103
Contact:Contact: Samer E. Bibawi 336-718-8181
United States, North Dakota
Cancer Care Center at Medcenter One Hospital
[Recruiting]
Bismarck, North Dakota, United States, 58501
Contact:Contact: Edward J. Wos, DO 701-323-5741
Dakota Cancer Institute at Innovis Health - Dakota Clinic
[Recruiting]
Fargo, North Dakota, United States, 58103
Contact:Contact: Kaushik Sen, MD 701-364-8910
Trinity Cancer Care Center
[Recruiting]
Minot, North Dakota, United States, 58701
Contact:Contact: Paul H. Freiberg, MD 701-852-0719
United States, Ohio
Aultman Hospital Cancer Center at Aultman Health Foundation
[Recruiting]
Canton, Ohio, United States, 44710-1799
Contact:Contact: Clinical Trials Office - Aultman Hospital Cancer Center 330-363-4857
MetroHealth's Cancer Care Center at MetroHealth Medical Center
[Recruiting]
Cleveland, Ohio, United States, 44109
Contact:Contact: Bruce J. Averbook, MD, FACS 216-778-4795
St. Joseph Cancer Center at St. Joseph Health Center
[Recruiting]
Warren, Ohio, United States, 44484
Contact:Contact: Clinical Trials Office - St. Joseph Cancer Center 330-841-4372
United States, Oklahoma
Comanche County Memorial Hospital
[Recruiting]
Lawton, Oklahoma, United States, 73505
Contact:Contact: Nadim F. Nimeh, MD 580-355-8699 ext. 4200
United States, Pennsylvania
Geisinger Medical Center
[Recruiting]
Danville, Pennsylvania, United States, 17822-0001
Contact:Contact: Clinical Trials Office - Geisinger Medical Center 570-271-5251
Geisinger Medical Group - Scenery Park
[Recruiting]
State College, Pennsylvania, United States, 16801
Contact:Contact: Albert M. Bernath, MD 814-231-4560
Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
[Recruiting]
Wilkes-Barre, Pennsylvania, United States, 18711
Contact:Contact: Clinical Trials Office - Frank M. and Dorothea Henry Cancer Ce 570-271-5251
United States, South Carolina
McLeod Regional Medical Center
[Recruiting]
Florence, South Carolina, United States, 29501
Contact:Contact: Clinical Trials Office - McLeod Regional Medical Center 843-679-7256
CCOP - Greenville
[Recruiting]
Greenville, South Carolina, United States, 29615
Contact:Contact: Jeffrey K. Giguere, MD, FACP 864-241-6251
United States, South Dakota
Avera Cancer Institute
[Recruiting]
Sioux Falls, South Dakota, United States, 57105
Contact:Contact: Loren K. Tschetter, MD 605-328-8000
Sioux Valley Hospital and University of South Dakota Medical Center
[Recruiting]
Sioux Falls, South Dakota, United States, 57117-5039
Contact:Contact: Clinical Trials Office - Sioux Valley Hospital and University 605-328-1367
United States, Texas
St. Joseph Regional Cancer Center
[Recruiting]
Bryan, Texas, United States, 77802
Contact:Contact: Usha Venkatraj, MD 979-774-0900
United States, Vermont
Mountainview Medical
[Recruiting]
Berlin, Vermont, United States, 05602
Contact:Contact: Susan Burdette-Radoux, MD 802-847-3827
Fletcher Allen Health Care - University Health Center Campus
[Recruiting]
Burlington, Vermont, United States, 05401
Contact:Contact: Susan Burdette-Radoux, MD 802-847-3827
United States, Virginia
Danville Regional Medical Center
[Recruiting]
Danville, Virginia, United States, 24541
Contact:Contact: Clinical Trials Office - Danville Regional Medical Center 434-799-3753
United States, Washington
St. Joseph Hospital Community Cancer Center
[Recruiting]
Bellingham, Washington, United States, 98225
Contact:Contact: Saul E. Rivkin, MD 206-386-2929
Group Health Central Hospital
[Recruiting]
Seattle, Washington, United States, 98104-1387
Contact:Contact: Saul E. Rivkin, MD 206-386-2929
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
[Recruiting]
Seattle, Washington, United States, 98122-4307
Contact:Contact: Saul E. Rivkin, MD 206-386-2929
University Cancer Center at University of Washington Medical Center
[Recruiting]
Seattle, Washington, United States, 98195-6043
Contact:Contact: Clinical Trials Office - University of Washington Cancer Cente 206-616-8289
Cancer Care Northwest - Spokane South
[Recruiting]
Spokane, Washington, United States, 99202
Contact:Contact: Clinical Trials Office - Cancer Care Northwest - Spokane South 509-228-1081
Madigan Army Medical Center - Tacoma
[Recruiting]
Tacoma, Washington, United States, 98431
Contact:Contact: David E. McCune, MD 253-968-2504
United States, West Virginia
Mary Babb Randolph Cancer Center at West Virginia University Hospitals
[Recruiting]
Morgantown, West Virginia, United States, 26506
Contact:Contact: Jame Abraham, MD 304-293-4229
United States, Wisconsin
All Saints Cancer Center at All Saints Medical Center
[Recruiting]
Racine, Wisconsin, United States, 53405
Contact:Contact: Richard N. Odders, MD 262-687-5000
University of Wisconsin Cancer Center at Aspirus Wausau Hospital
[Recruiting]
Wausau, Wisconsin, United States, 54401
Contact:Contact: Clinical Trials Office - University of Wisconsin Cancer Center 608-262-5223
Australia, New South Wales
Cancer Therapy Centre at Campbelltown Hospital
[Recruiting]
Campbelltown, New South Wales, Australia, 2560
Contact:Contact: Stephen Della-Fiorentina, MD 61-2-4634-4355
Cancer Therapy Centre at Liverpool Hospital
[Recruiting]
Liverpool, New South Wales, Australia, 2170
Contact:Contact: Stephen Della-Fiorentina, MD 61-2-9828-5282
Australia, Tasmania
Royal Hobart Hospital
[Recruiting]
Hobart, Tasmania, Australia, 7000
Contact:Contact: Raymond M. Lowenthal, MD 61-3-6222-8157 r.m.lowenthal@utas.edu.au
Australia, Victoria
Breast Unit Mercy Private
[Recruiting]
East Melbourne, Victoria, Australia, 3002
Contact:Contact: Mitchell Chipman, MD 61-3-9419-1166 drmpc@bigpond.com
Peter MacCallum Cancer Centre
[Recruiting]
East Melbourne, Victoria, Australia, 3002
Contact:Contact: Prudence Francis, MD 61-39-656-1701 Prue.Francis@petermac.org
Maroondah Hospital
[Recruiting]
East Ringwood, Victoria, Australia, 3135
Contact:Contact: J. Chirgwin, MD 61-3-9871-3582
Austin Hospital
[Recruiting]
Heidelberg, Victoria, Australia, 3084
Contact:Contact: Mitchell Chipman, MD 61-3-9457-1029 drmpc@bigpond.com
Australia, Western Australia
Royal Perth Hospital
[Recruiting]
Perth, Western Australia, Australia, 6000
Contact:Contact: E Bayliss, MBBS, FRACP 011-61-8-9224-2334 evan.bayliss@health.wa.gov.au
Canada, Alberta
Tom Baker Cancer Centre - Calgary
[Recruiting]
Calgary, Alberta, Canada, T2N 4N2
Contact:Contact: Barbara A. Walley, MD, FRCPC 403-944-1013
Cross Cancer Institute at University of Alberta
[Recruiting]
Edmonton, Alberta, Canada, T6G 1Z2
Contact:Contact: Katia S. Tonkin, MD 780-432-8771
Canada, Ontario
Margaret and Charles Juravinski Cancer Centre
[Recruiting]
Hamilton, Ontario, Canada, L8V 5C2
Contact:Contact: Richard Tozer, MD, PhD 905-387-9495ext64604
Trillium Health Centre - Mississauga Site
[Recruiting]
Mississauga, Ontario, Canada, L5B 1B8
Contact:Contact: John A.P. Gapski, MD 905-270-3842
Canada, Quebec
Hopital Charles Lemoyne
[Recruiting]
Greenfield Park, Quebec, Canada, J4V 2H1
Contact:Contact: Catherine Prady, MD 450-466-5000ext3376
Hopital Du Sacre-Coeur de Montreal
[Recruiting]
Montreal, Quebec, Canada, H4J 1C5
Contact:Contact: Josee-Anne Roy 514-338-2150
Canada, Saskatchewan
Allan Blair Cancer Centre at Pasqua Hospital
[Recruiting]
Regina, Saskatchewan, Canada, S4T 7T1
Contact:Contact: Muhammad Salim, MD 306-766-2203
Saskatoon Cancer Centre at the University of Saskatchewan
[Recruiting]
Saskatoon, Saskatchewan, Canada, S7N 4H4
Contact:Contact: Amer Sami, MD 306-655-2710
Hungary
National Institute of Oncology
[Recruiting]
Budapest, Hungary, 1122
Contact:Contact: Istvan Lang, MD, PhD, DSc 36-1-22-48-763 lang@oncol.hu
Italy
Centro di Riferimento Oncologico - Aviano
[Recruiting]
Aviano, Italy, 33081
Contact:Contact: Diana Crivellari, MD 39-0434-659-024 dcrivellari@oro.it
Ospedali Riuniti di Bergamo
[Recruiting]
Bergamo, Italy, 24100
Contact:Contact: Carlo Tondini, MD 39-03-526-6424 carlo.tondoni@ospedaliriuniti.bergamo.it
Ospedale B. Ramazzini
[Recruiting]
Carpi, Italy, 41012
Contact:Contact: Fabrizio Artioli, MD 39-059-659-313 f.artioli@ausl.mo.it
European Institute of Oncology
[Recruiting]
Milan, Italy, 20141
Contact:Contact: Aron Goldhirsch, MD 39-02-574-894-39 aron.goldhirsch@ibcsg.org
Fondazione Salvatore Maugeri
[Recruiting]
Pavia, Italy, I-27100
Contact:Contact: Lorenzo Pavesi 39-382-592-669
Ospedale Civile Rimini
[Recruiting]
Rimini, Italy, 47900
Contact:Contact: Alberto Ravaioli, MD 39-541-705-409 aravaiol@auslrn.net
Policlinico Universitario
[Recruiting]
Udine, Italy, 33100
Contact:Contact: Fabio Puglisi 39-4-3255-9304 fabio.puglisi@med.uniud.it
Ospedale di Circolo e Fondazione Macchi
[Recruiting]
Varese, Italy, 21100
Contact:Contact: Graziella Pinotti 39-332-278-558
Peru
Instituto Nacional de Enfermedades Neoplasicas
[Recruiting]
Lima, Peru, 34
Contact:Contact: Henry Gomez Moreno 51-1-710-6900
South Africa
Sandton Oncology Centre
[Recruiting]
Johannesburg, South Africa, 2121
Contact:Contact: Daniel A. Vorobiof, MD 27-11-883-0900 voro@global.co.za
Switzerland
Oncology Institute of Southern Switzerland
[Recruiting]
Bellinzona, Switzerland, CH-6500
Contact:Contact: Olivia Pagani, MD 41-91-820-9111 olivia.pagani@ibcsg.org
Ospedale "la Carita", Locarno
[Recruiting]
Locarno, Switzerland, 6600
Contact:Contact: Olivia Pagani, MD 41-91-811-3111
Ospedale Civico
[Recruiting]
Lugano, Switzerland, CH-6903
Contact:Contact: Olivia Pagani, MD 41-91-811-3111
Ospedale Beata Vergine
[Recruiting]
Mendrisio, Switzerland, CH-6850
Contact:Contact: Olivia Pagani, MD 41-91-811-3667
Kantonsspital - St. Gallen
[Recruiting]
St. Gallen, Switzerland, CH-9007
Contact:Contact: Beat Thurlimann, MD 41-71-494-1178 beat.thuerlimann@kssg.ch
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