Effects of Growth Hormone on the Nitric Oxide Pathway
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT00470002 |
Recruitment Status :
Completed
First Posted : May 7, 2007
Last Update Posted : May 7, 2007
|
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Cardiovascular Disease | Drug: Somatropin | Phase 1 |
Nitric oxide (NO) is a potent endogenous vasodilator and has shown to inhibit key processes of atherosclerosis like monocyte adhesion, platelet aggregation, and vascular smooth muscle cell proliferation. Impaired endothelial NO production is a main feature of endothelial dysfunction, which by itself is an early step in the course of atherosclerotic vascular disease.
Recent studies could confirm this close association between parameters of the NO pathway and cardiovascular disease and could further enhance the knowledge on the pathophysiological mechanisms. There is a significant relationship between insulin resistance and the endogenous NO synthase inhibitor asymmetric dimethylarginine (ADMA). Moreover, evidence could be provided that plasma levels of ADMA are a strong and independent predictor of mortality and cardiovascular outcome in haemodialysis patients.
Patients with growth hormone deficiency are characterized by a 1.9 fold higher risk of death from cardiovascular disease. Again, there is good evidence, that alterations of the NO-pathway are involved in this increase of cardiovascular risk. A reduced endogenous systemic production of NO was found in patients with growth hormone deficiency, treatment with recombinant growth hormone normalized NO production. The effects of growth hormone on NO are possibly mediated by insulin-like growth factor-I (IGF-I), which stimulates NO synthesis in vitro. The onset of IGF-I increase in healthy volunteers treated with GH is evident after 12 h, the maximum effect takes place between 5 to 8 days. Also in adults with growth hormone deficiency, the major effects of growth hormone treatment on IGF-I levels are observed within 2 weeks. After discontinuation of growth hormone therapy, IGF-1 levels return to base line within 2-3 days.
The aim of the present study is to further elucidate the in vivo effects of GH on the NO pathway and NO mediated cardiovascular functions.
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 16 participants |
Allocation: | Non-Randomized |
Intervention Model: | Single Group Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Basic Science |
Official Title: | Effects of Growth Hormone (GH) on Parameters of the Nitric Oxide (NO) Pathway |
Study Start Date : | May 2004 |
Actual Study Completion Date : | January 2005 |
- Urinary nitrate excretion [ Time Frame: 10 days ]
- Insulin-like growth factor-1 in serum [ Time Frame: 10 days ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 50 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Healthy male subjects without recent severe diseases
- Age 50 yrs or older
- Body mass index at or below 30 kg/m2
- Insulin-like growth factor-1 level below 200 ng/ml
- Evidence of a personally signed and dated informed consent document indicating that the subject has been informed of all pertinent aspects of the trial
- Subjects that are willing and able to comply with scheduled visits, treatment plan, laboratory tests and other study procedures
Exclusion Criteria:
- History of any severe hepatic, renal, cardiac, endocrine, metabolic, or malignant diseases
- Requirement for medical drug treatment
- Growth hormone treatment during the last 12 months
- Drug dependence, alcohol or nicotine abuse
- Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or may interfere with the interpretation of study results and, in the judgement of the investigator, would make the subject inappropriate for entry into this study.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00470002
Germany | |
Institute of Clinical Pharmacology, Hannover Medical School | |
Hannover, Lower Saxony, Germany, 30623 |
Study Director: | Dirk O Stichtenoth, MD | Institute of Clinical Pharmacology, Hannover Medical School |
ClinicalTrials.gov Identifier: | NCT00470002 |
Other Study ID Numbers: |
MES 03069 VP2-3900-4021576 IRB#3444 |
First Posted: | May 7, 2007 Key Record Dates |
Last Update Posted: | May 7, 2007 |
Last Verified: | May 2007 |
growth hormone nitric oxide nitrate cyclic guanosine monophosphate |
insulin-like growth factor-1 asymmetric dimethylarginine blood pressure endothelial progenitor cells |
Cardiovascular Diseases |