Continuous Positive Airway Pressure (CPAP) Treatment in Coronary Artery Disease and Sleep Apnea (RICCADSA)
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ClinicalTrials.gov Identifier: NCT00519597 |
Recruitment Status :
Completed
First Posted : August 22, 2007
Last Update Posted : November 15, 2018
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Coronary Artery Disease Obstructive Sleep Apnea | Device: ResMed S8 (Auto-CPAP) | Phase 4 |
Rationale: OSA is a common condition in CAD with a poor prognosis.Many of these subjects do not report daytime sleepiness, and therefore, are not considered for OSA treatment with CPAP. There is lack of evidence regarding the impact of CPAP on the long-term prognosis of CAD patients with OSA.
Objective: The RICCADSA trial is designed to address if CPAP treatment reduces the combined rate of new revascularization, myocardial infarction, stroke and cardiovascular mortality over a mean follow-up period of 3-years in CAD patients with OSA (Apnea-Hypopnea-Index [AHI]>=15 per h) without daytime sleepiness (Epworth Sleepiness Scale [ESS]<10). Secondary outcomes include cardiovascular biomarkers, cardiac function, maximal exercise capacity and quality of life at baseline, 3-month- and 1-year follow-up as well as polysomnographic findings and adherence to CPAP therapy.
Patients and Methods: A sample of 511 CAD patients (122 non-sleepy OSA patients randomized to CPAP, 122 to non-CPAP; 155 sleepy OSA patients [ESS>=10] on CPAP, and 112 CAD patients without OSA [AHI <5 per h]) were included. The trial has 80% power to detect a risk reduction from an assumed composite end-point rate of 25% to 12% for the primary outcome at intention-to-treat basis.
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 511 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Treatment |
Official Title: | Randomized Intervention With CPAP in Coronary Artery Disease and Sleep Apnea - RICCADSA Trial |
Study Start Date : | December 2005 |
Actual Primary Completion Date : | March 2013 |
Actual Study Completion Date : | May 2013 |
Arm | Intervention/treatment |
---|---|
Experimental: I
Asymptomatic OSA (CPAP)
|
Device: ResMed S8 (Auto-CPAP)
AutoCPAP during sleep |
No Intervention: II
Asymptomatic OSA (no CPAP)
|
|
Active Comparator: III
Symptomatic OSA (OSAS)
|
Device: ResMed S8 (Auto-CPAP)
AutoCPAP during sleep |
No Intervention: IV
Non-OSA
|
- The combined rate of cardiovascular mortality, stroke, myocardial infarction and the need for a new revascularization. [ Time Frame: Three years ]
- Cardiovascular biomarkers, left ventricular function, maximal exercise capacity, quality of life, anxiety and depression state. [ Time Frame: Three months and one year, respectively. ]
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Ages Eligible for Study: | Child, Adult, Older Adult |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Patients with angiographically-verified CAD who have newly undergone PCI or CABG treatment
- Written, informed study consent
- OSA (AHI>=15 per hour) or non-OSA (AHI<5 per hour) diagnosis on the unattended sleep recording at home
Exclusion Criteria:
- Patients with already treated OSAS
- Patients presenting mainly central apneas (Cheynes-Stokes breathing)
- Patients with borderline OSA (AHI <15 and >=5 per hour) upon the unattended sleep recording at home
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00519597
Sweden | |
Skaraborg Hospital | |
Skövde, Sweden, 54185 |
Study Chair: | Yüksel Peker, Ass. Prof. | Göteborg University |
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | Yuksel Peker, MD, PhD, Associate Professor, Skaraborg Hospital |
ClinicalTrials.gov Identifier: | NCT00519597 |
Other Study ID Numbers: |
VGSKAS-4731 |
First Posted: | August 22, 2007 Key Record Dates |
Last Update Posted: | November 15, 2018 |
Last Verified: | November 2018 |
Coronary Artery Disease Sleep Apnea CPAP Revascularization Mortality |
Apnea Sleep Apnea Syndromes Sleep Apnea, Obstructive Coronary Artery Disease Myocardial Ischemia Coronary Disease Respiration Disorders Respiratory Tract Diseases Signs and Symptoms, Respiratory |
Heart Diseases Cardiovascular Diseases Arteriosclerosis Arterial Occlusive Diseases Vascular Diseases Sleep Disorders, Intrinsic Dyssomnias Sleep Wake Disorders Nervous System Diseases |