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Application of Two Different Synthetic Sequential Media for the Human IVF-Embryo Transfer (IVF-ET) Program

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ClinicalTrials.gov Identifier: NCT01356238
Recruitment Status : Completed
First Posted : May 19, 2011
Last Update Posted : May 19, 2011
Sponsor:
Information provided by:
Maria Fertility Hospital

Study Description
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Brief Summary:
Quality-controlled commercial media have been used in many in-vitro fertilization (IVF) laboratories. However, commercial media are costly and difficult to compare directly because their exact compositions are not clearly indicated. Although commercially available media have commonly been used in most IVF programs worldwide, there are several advantages to the use of in-house synthetic sequential media at IVF laboratories. First, the results of quality control should be reliable due to a stringent protocol setting-up. Second, any direct supplementations or deletions of specific components are feasible to obtain good quality embryos and high pregnancy rates since those components can be defined. Finally, dependence on commercially available media diminishes so that the laboratory can more easily accommodate unexpected situations or problems, such as a sudden increase in IVF patients. Therefore, the present study was conducted to compare the efficacy of in-house MRC media in the human IVF-embryo transfer (ET) program to that of commercially available media.

Condition or disease Intervention/treatment Phase
Infertility Other: MRC media Other: Sydney IVF media Not Applicable

Study Design
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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 360 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Official Title: Application of Two Different Synthetic Sequential Media for the Human IVF-ET Program
Study Start Date : November 2009
Actual Primary Completion Date : September 2010
Actual Study Completion Date : October 2010
Arms and Interventions
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Arm Intervention/treatment
Experimental: MRC media
Use MRC media in the human IVF-ET program
 Other: MRC media
Culture media
Active Comparator: Sydney IVF media
Use Sydney IVF media in the human IVF-ET program
 Other: Sydney IVF media
Culture media


Outcome Measures
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Primary Outcome Measures :
  1. Embryo Quality [ Time Frame: 3 Days ]

Secondary Outcome Measures :
  1. Pregnancy and Implantation rates [ Time Frame: 2 months ]

Eligibility Criteria
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Ages Eligible for Study:   20 Years to 39 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Patients undergoing IVF treatment in our clinic during study period

Exclusion Criteria:

  • Females older than 40 years
  • Patients showed fertilization failure
  • Patients with less than two 2PN embryos
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01356238


Locations
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Korea, Republic of
Maria Fertility Hospital
Seoul, Korea, Republic of, 130-812
Sponsors and Collaborators
Maria Fertility Hospital
Investigators
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Principal Investigator: Jeong Yoon, M.S. Maria Fertility Hospital
More Information
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Responsible Party: Jeong Yoon, Maria Fertility Hospital
ClinicalTrials.gov Identifier: NCT01356238    
Other Study ID Numbers: MRC-1
First Posted: May 19, 2011    Key Record Dates
Last Update Posted: May 19, 2011
Last Verified: October 2009
Additional relevant MeSH terms:
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Infertility
Genital Diseases
Urogenital Diseases