Dimethyl Fumarate (DMF) Observational Study (ESTEEM)
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT02047097 |
Recruitment Status :
Completed
First Posted : January 28, 2014
Last Update Posted : May 24, 2023
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Condition or disease | Intervention/treatment |
---|---|
Multiple Sclerosis | Drug: dimethyl fumarate |
Study Type : | Observational [Patient Registry] |
Actual Enrollment : | 5487 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Target Follow-Up Duration: | 5 Years |
Official Title: | A Multicenter, Global, Observational Study to Collect Information on Safety and to Document the Drug Utilization of Tecfidera™ (Dimethyl Fumarate) When Used in Routine Medical Practice in the Treatment of Multiple Sclerosis (ESTEEM) |
Actual Study Start Date : | November 19, 2013 |
Actual Primary Completion Date : | October 31, 2022 |
Actual Study Completion Date : | October 31, 2022 |
Group/Cohort | Intervention/treatment |
---|---|
dimethyl fumarate (DMF)
Patients with multiple sclerosis receiving dimethyl fumarate (DMF) under routine clinical care
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Drug: dimethyl fumarate
Provided under routine clinical care
Other Names:
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- The number of participants that experience Adverse Events (AEs) that lead to discontinuation of dimethyl fumarate (DMF) [ Time Frame: Up to 5 years ]
- The number of participants that experience Serious Adverse Events (SAEs) [ Time Frame: Up to 5 years ]
- Duration of dimethyl fumarate (DMF) use [ Time Frame: Up to 5 years ]
- dimethyl fumarate (DMF) dosing frequency [ Time Frame: Up to 5 years ]
- Primary reasons for discontinuation of dimethyl fumarate (DMF) use [ Time Frame: Up to 5 years ]
- Frequency of relapses over time [ Time Frame: Up to 5 years ]
- Disease progression as measured by Expanded Disability Status Scale (EDSS) over time [ Time Frame: Up to 5 years ]The EDSS measures disability status on a scale ranging from 0 to 10, with higher scores indicating more disability. Scoring is based on measures of impairment in eight functional systems on examination by a neurologist. Participants with confirmed progression of disability in EDSS physical functional system scores will be defined as those who meet one of the following criteria: an increase of ≥ 1 point from baseline system score of ≥ 1 or an increase of ≥ 2 points from baseline system score of 0 in at least 2 physical functional systems, or an increase of ≥ 2 points from baseline system score of ≥ 1 or an increase of ≥ 3 points from baseline system score of 0 in any 1 physical functional system. Worsening must be confirmed on a subsequent examination using the same criterion in the same functional system(s) at least 6 months later.
- Multiple Sclerosis Impact Scale-29 Items (MSIS-29) physical multiple sclerosis (MS) impact score [ Time Frame: Up to 5 years ]The 29-item Multiple Sclerosis Impact Scale (MSIS-29) is a patient-reported outcome measure to assess the impact of MS on day-to-day life during the past 2 weeks from a patient's perspective; it measures 20 physical items and 9 psychological items. The physical score is generated by summing individual items and then transforming to a scale with a range of 0 to 100, where high scores indicate worse health.
- Multiple Sclerosis Impact Scale-29 Items (MSIS-29) psychological multiple sclerosis (MS) impact score [ Time Frame: Up to 5 years ]The 29-item Multiple Sclerosis Impact Scale (MSIS-29) is a patient-reported outcome measure to assess the impact of MS on day-to-day life during the past 2 weeks from a patient's perspective; it measures 20 physical items and 9 psychological items. The physical score is generated by summing individual items and then transforming to a scale with a range of 0 to 100, where high scores indicate worse health.
- EuroQol-5 Dimensions (5 Level) (EQ-5D-5L) index score [ Time Frame: Up to 5 years ]Descriptive system of health-related quality of life states consisting of five dimensions (mobility, self-care, usual activities, pain/discomfort, anxiety/depression) each of which can take one of five responses. The responses record five levels of severity (no problems/slight problems/moderate problems/severe problems/extreme problems) within a particular EQ-5D dimension.
- EuroQol Visual Analogue Scale (EQ VAS) (0-100 scale) [ Time Frame: Up to 5 years ]Standard vertical 20 cm visual analogue scale (similar to a thermometer) for recording an individual's rating for their current health-related quality of life state (often referred to as page 3 of the EQ-5D questionnaire)
- Modified Fatigue Impact Scale-5 (MFIS-5) total score [ Time Frame: Up to 5 years ]MFIS-5 is a modified form of the Fatigue Impact Scale that consists of five questions that assess the impact of fatigue on physical, cognitive, and psychosocial functioning, with five response levels ranging from 0 ("Never") to 4 ("Almost always"). Total scores range from 0 to 20, with higher scores representing a greater impact of fatigue.
- Work Productivity and Activity Impairment questionnaire: Multiple Sclerosis, Version 2.0 (WPAI-MS) impairment percentages [ Time Frame: Up to 5 years ]The Work Productivity and Activity Impairment (WPAI) questionnaire is a validated instrument to measure impairments in work and activities. The WPAI yields four types of scores: 1. Absenteeism (work time missed) 2. Presenteesism (impairment at work / reduced on-the-job effectiveness) 3. Work productivity loss (overall work impairment / absenteeism plus presenteeism) 4. Activity Impairment. WPAI outcomes are expressed as impairment percentages, with higher numbers indicating greater impairment and less productivity.
- Health Care Resource Consumption Questionnaire [ Time Frame: Up to 5 years ]The Health Care Resource Consumption questionnaire is a survey that asks patients how MS affects their use of healthcare services and the impact it has on particular areas of their life (including number of hospitalizations [MS-related, non-MS related, relapse-related, resulting in steroid use], MS-related emergency room visits, MS-related neurologist visits, visits to other health care professionals for MS-related and other reasons).
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Key Inclusion Criteria:
- Patients with multiple sclerosis (MS) who are newly initiating treatment with dimethyl fumarate (DMF) under routine clinical care are eligible to participate in the study.
Key Exclusion Criteria:
- Patients with previous exposure to dimethyl fumarate (DMF), Fumaderm (fumaric acid esters), or compounded fumarates.
- Patients participating in other clinical studies.
NOTE: Other protocol-defined inclusion/exclusion criteria may apply.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02047097
United States, Alabama | |
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Birmingham, Alabama, United States, 35209 | |
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Huntsville, Alabama, United States, 35801 | |
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Gilbert, Arizona, United States, 85234 | |
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Phoenix, Arizona, United States, 85006 | |
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Phoenix, Arizona, United States, 85018 | |
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Phoenix, Arizona, United States, 85048 | |
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Scottsdale, Arizona, United States, 85251 | |
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Tucson, Arizona, United States, 85718 | |
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Fullerton, California, United States, 92835 | |
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Hanford, California, United States, 93230 | |
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Loma Linda, California, United States, 92354 | |
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Los Angeles, California, United States, 90015 | |
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Los Angeles, California, United States, 90048 | |
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Newport Beach, California, United States, 92663 | |
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San Francisco, California, United States, 94158 | |
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Santa Ana, California, United States, 92704 | |
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Aurora, Colorado, United States, 80045 | |
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Colorado Springs, Colorado, United States, 80907 | |
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Denver, Colorado, United States, 80210 | |
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Fort Collins, Colorado, United States, 80528 | |
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Danbury, Connecticut, United States, 06810 | |
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Derby, Connecticut, United States, 06418 | |
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Hartford, Connecticut, United States, 06112 | |
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Norwich, Connecticut, United States, 06360 | |
United States, Delaware | |
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Dover, Delaware, United States, 19901 | |
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Wilmington, Delaware, United States, 19801 | |
United States, District of Columbia | |
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Washington, District of Columbia, United States, 20007 | |
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Washington, District of Columbia, United States, 20037 | |
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Boca Raton, Florida, United States, 33486 | |
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Gainesville, Florida, United States, 32610 | |
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Jacksonville, Florida, United States, 32216 | |
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Lighthouse Point, Florida, United States, 33064 | |
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Maitland, Florida, United States, 32751 | |
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Miami, Florida, United States, 33125 | |
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Port Charlotte, Florida, United States, 33952 | |
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Saint Petersburg, Florida, United States, 33710 | |
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Saint Petersburg, Florida, United States, 33713 | |
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Sarasota, Florida, United States, 34233 | |
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Tampa, Florida, United States, 33606 | |
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Atlanta, Georgia, United States, 30309 | |
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Atlanta, Georgia, United States, 30309 | |
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Atlanta, Georgia, United States, 30327 | |
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Augusta, Georgia, United States, 30912 | |
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Columbus, Georgia, United States, 31909 | |
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Savannah, Georgia, United States, 31406 | |
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Chicago, Illinois, United States, 60611 | |
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Chicago, Illinois, United States, 60637 | |
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Evanston, Illinois, United States, 60201 | |
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Herrin, Illinois, United States, 62948 | |
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Peoria, Illinois, United States, 61603 | |
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Winfield, Illinois, United States, 60190 | |
United States, Indiana | |
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Elkhart, Indiana, United States, 46514 | |
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Indianapolis, Indiana, United States, 46202 | |
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Des Moines, Iowa, United States, 50309 | |
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Des Moines, Iowa, United States, 50314 | |
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Waterloo, Iowa, United States, 50702 | |
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Overland Park, Kansas, United States, 66211 | |
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Overland Park, Kansas, United States, 66212 | |
United States, Kentucky | |
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Henderson, Kentucky, United States, 42420 | |
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Louisville, Kentucky, United States, 40207 | |
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Hammond, Louisiana, United States, 70403 | |
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New Orleans, Louisiana, United States, 70121 | |
United States, Maine | |
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Rockport, Maine, United States, 04856 | |
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Baltimore, Maryland, United States, 21201 | |
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Baltimore, Maryland, United States, 21287 | |
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Bethesda, Maryland, United States, 20814 | |
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Cumberland, Maryland, United States, 21502 | |
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Glen Burnie, Maryland, United States, 21061 | |
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Boston, Massachusetts, United States, 02111 | |
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Boston, Massachusetts, United States, 02135 | |
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Foxboro, Massachusetts, United States, 02035 | |
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Jamaica Plain, Massachusetts, United States, 02130 | |
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Lexington, Massachusetts, United States, 02421 | |
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Wellesley, Massachusetts, United States, 02481 | |
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Worcester, Massachusetts, United States, 01655 | |
United States, Michigan | |
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Ann Arbor, Michigan, United States, 48109 | |
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East Lansing, Michigan, United States, 48824 | |
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Farmington Hills, Michigan, United States, 48334 | |
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West Bloomfield, Michigan, United States, 48322 | |
United States, Minnesota | |
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Edina, Minnesota, United States, 55435 | |
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Minneapolis, Minnesota, United States, 55407 | |
United States, Mississippi | |
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Ocean Springs, Mississippi, United States, 39564 | |
United States, Missouri | |
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Saint Louis, Missouri, United States, 63110 | |
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Springfield, Missouri, United States, 65806 | |
United States, Montana | |
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Billings, Montana, United States, 59101 | |
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Great Falls, Montana, United States, 59405 | |
United States, Nebraska | |
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Lincoln, Nebraska, United States, 68506 | |
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Lincoln, Nebraska, United States, 68521 | |
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Wahoo, Nebraska, United States, 68066 | |
United States, Nevada | |
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Las Vegas, Nevada, United States, 89106 | |
United States, New Hampshire | |
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Concord, New Hampshire, United States, 03301 | |
United States, New Jersey | |
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Audubon, New Jersey, United States, 08106 | |
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Flemington, New Jersey, United States, 08822 | |
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Hackensack, New Jersey, United States, 07601 | |
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Livingston, New Jersey, United States, 07039 | |
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New Brunswick, New Jersey, United States, 08903 | |
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Newark, New Jersey, United States, 07103 | |
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Stratford, New Jersey, United States, 08084 | |
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Toms River, New Jersey, United States, 08755 | |
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West Long Branch, New Jersey, United States, 07764 | |
United States, New York | |
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Albany, New York, United States, 12206 | |
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Cedarhurst, New York, United States, 11516 | |
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East Meadow, New York, United States, 11554 | |
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Kingston, New York, United States, 12401 | |
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New York, New York, United States, 10016 | |
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New York, New York, United States, 10029 | |
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Patchogue, New York, United States, 11772 | |
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Plainview, New York, United States, 11803 | |
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Syracuse, New York, United States, 13202 | |
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Syracuse, New York, United States, 13210 | |
United States, North Carolina | |
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Asheville, North Carolina, United States, 28803 | |
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Charlotte, North Carolina, United States, 28204 | |
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Charlotte, North Carolina, United States, 28226 | |
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Greensboro, North Carolina, United States, 27405 | |
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Hendersonville, North Carolina, United States, 28792 | |
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Pinehurst, North Carolina, United States, 28370 | |
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Raleigh, North Carolina, United States, 27607 | |
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Wilmington, North Carolina, United States, 28401 | |
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Winston-Salem, North Carolina, United States, 27157 | |
United States, North Dakota | |
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Bismarck, North Dakota, United States, 58501 | |
United States, Ohio | |
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Canton, Ohio, United States, 44735 | |
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Centerville, Ohio, United States, 45459 | |
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Cincinnati, Ohio, United States, 45267 | |
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Cleveland, Ohio, United States, 44195 | |
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Columbus, Ohio, United States, 43210 | |
United States, Oklahoma | |
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Oklahoma City, Oklahoma, United States, 73104 | |
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Tulsa, Oklahoma, United States, 74136 | |
United States, Oregon | |
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Portland, Oregon, United States, 97225 | |
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Portland, Oregon, United States, 97239 | |
United States, Pennsylvania | |
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Abington, Pennsylvania, United States, 19001 | |
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Allentown, Pennsylvania, United States, 18103 | |
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Greensburg, Pennsylvania, United States, 15601 | |
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Meadowbrook, Pennsylvania, United States, 19046 | |
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Monroeville, Pennsylvania, United States, 15146 | |
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Natrona Heights, Pennsylvania, United States, 15065 | |
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Philadelphia, Pennsylvania, United States, 19107 | |
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Pittsburgh, Pennsylvania, United States, 15212 | |
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Columbia, South Carolina, United States, 29203 | |
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Greenville, South Carolina, United States, 29605 | |
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Spartanburg, South Carolina, United States, 29307 | |
United States, Tennessee | |
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Franklin, Tennessee, United States, 37064 | |
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Knoxville, Tennessee, United States, 37920 | |
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Knoxville, Tennessee, United States, 37922 | |
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Nashville, Tennessee, United States, 37205 | |
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Nashville, Tennessee, United States, 37232 | |
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Arlington, Texas, United States, 76012 | |
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Colleyville, Texas, United States, 76034 | |
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Dallas, Texas, United States, 75246 | |
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Dallas, Texas, United States, 75390 | |
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Houston, Texas, United States, 77030 | |
United States, Virginia | |
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Norfolk, Virginia, United States, 23502 | |
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Richmond, Virginia, United States, 23298 | |
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Virginia Beach, Virginia, United States, 23456 | |
United States, Washington | |
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Kirkland, Washington, United States, 98034 | |
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Seattle, Washington, United States, 98101 | |
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Spokane, Washington, United States, 99208 | |
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Tacoma, Washington, United States, 98405 | |
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Tacoma, Washington, United States, 98409 | |
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Green Bay, Wisconsin, United States, 54301 | |
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Green Bay, Wisconsin, United States, 54303 | |
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Green Bay, Wisconsin, United States, 54308 | |
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Green Bay, Wisconsin, United States, 54311 | |
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La Crosse, Wisconsin, United States, 54601 | |
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Madison, Wisconsin, United States, 53715 | |
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Milwaukee, Wisconsin, United States, 53211 | |
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Milwaukee, Wisconsin, United States, 53215 | |
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Neenah, Wisconsin, United States, 54956 | |
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Waukesha, Wisconsin, United States, 53188 | |
Argentina | |
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Ciudad Autonoma Buenos Aires, Buenos Aires, Argentina, C1181ACH | |
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Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1061ABD | |
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Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1425DKT | |
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Vicente Lopez, Buenos Aires, Argentina, 1602 | |
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Rosario, Santa Fe, Argentina, S2000DFD | |
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Rosario, Santa Fe, Argentina, S2000 | |
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San Miguel de Tucuman, Tucuman, Argentina, 4000 | |
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Ciudad Autonoma Buenos Aires, Argentina, 1199 | |
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Ciudad Autonoma Buenos Aires, Argentina, C1013AAB | |
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Ciudad Autonoma Buenos Aires, Argentina, C1118AAT | |
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Ciudad Autonoma Buenos Aires, Argentina, C1192AAW | |
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Cordoba, Argentina, 5000 | |
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Cordoba, Argentina, X5004CDT | |
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Guaymallén, Argentina, 5519 | |
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Mendoza, Argentina, M5502AWY | |
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Salta, Argentina, 4400 | |
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San Juan, Argentina, 5400 | |
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Santiago del Estero, Argentina, 4200 | |
Australia, New South Wales | |
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Camperdown, New South Wales, Australia, 2050 | |
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Concord, New South Wales, Australia, 2139 | |
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Kogarah, New South Wales, Australia, 2217 | |
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Liverpool, New South Wales, Australia, 2170 | |
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New Lambton Heights, New South Wales, Australia, 2305 | |
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Randwick, New South Wales, Australia, 2031 | |
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St. Leonards, New South Wales, Australia, 2065 | |
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Sydney, New South Wales, Australia, 2109 | |
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Westmead, New South Wales, Australia, 2145 | |
Australia, Queensland | |
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Auchenflower, Queensland, Australia, 4066 | |
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Gold Coast, Queensland, Australia, 9726 | |
Australia, South Australia | |
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Bedford Park, South Australia, Australia, 5042 | |
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Kent Town, South Australia, Australia, 5067 | |
Australia, Victoria | |
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Box Hill, Victoria, Australia, 3128 | |
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Clayton, Victoria, Australia, 3168 | |
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Geelong, Victoria, Australia, 3220 | |
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Heidelberg, Victoria, Australia, 3084 | |
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Melbourne, Victoria, Australia, 3004 | |
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Melbourne, Victoria, Australia, 3181 | |
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Parkville, Victoria, Australia, 3050 | |
Australia, Western Australia | |
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Nedlands, Western Australia, Australia, 6009 | |
Austria | |
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Amstetten, Austria, 3300 | |
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Salzburg, Austria, 5020 | |
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Vienna, Austria, 1040 | |
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Vienna, Austria, 1180 | |
Canada, Alberta | |
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Calgary, Alberta, Canada, T2N 2T9 | |
Canada, British Columbia | |
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Burnaby, British Columbia, Canada, V5H 4K7 | |
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Victoria, British Columbia, Canada, V8R 1J8 | |
Canada, New Brunswick | |
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Moncton, New Brunswick, Canada, E1C 6Z8 | |
Canada, Nova Scotia | |
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Halifax, Nova Scotia, Canada, B3H 1V7 | |
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Sydney, Nova Scotia, Canada, B1P 1P3 | |
Canada, Ontario | |
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Cambridge, Ontario, Canada, N1R7L6 | |
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London, Ontario, Canada, N6A 5A5 | |
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Milton, Ontario, Canada, L9T 5B5 | |
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Scarborough, Ontario, Canada, M1R 3A6 | |
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Thunder Bay, Ontario, Canada, P7B 6V4 | |
Canada, Quebec | |
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Gatineau, Quebec, Canada, J8Y 1W2 | |
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Montreal, Quebec, Canada, H2L 4M1 | |
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Montréal, Quebec, Canada, H2L 4M1 | |
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Montréal, Quebec, Canada, H3A 2B4 | |
Canada, Saskatchewan | |
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Regina, Saskatchewan, Canada, S4S 3R8 | |
Czechia | |
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Brno, Czechia, 656 91 | |
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Hradec Kralove, Czechia, 50333 | |
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Jihlava, Czechia, 58633 | |
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Olomouc, Czechia, 77520 | |
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Pardubice, Czechia, 532 03 | |
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Praha 10, Czechia, 100 34 | |
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Teplice, Czechia, 41529 | |
Denmark | |
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Aarhus C, Denmark, 8200 | |
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Esbjerg, Denmark, 6715 | |
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Glostrup, Denmark, 2600 | |
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Odense C, Denmark, 5000 | |
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Sønderborg, Denmark, 6400 | |
France | |
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Montlucon, Allier, France, 03113 | |
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Mulhouse Cedex, Haut Rhin, France, 68100 | |
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Toulouse cedex 9, Haute Garonne, France, 31059 | |
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Pringy cedex, Haute Savoie, France, 74374 | |
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Rueil Malmaison, Hauts De Seine, France, 92500 | |
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Dax cedex, Landes, France, 40107 | |
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Agen cedex 09, Lot Et Garonne, France, 47923 | |
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Perpignan, Pyrenees Orientales, France, 66046 | |
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Bron Cedex, Rhone, France, 69677 | |
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La Roche sur Yon, Vendee, France, 85925 | |
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Epinal cedex, Vosges, France, 88021 | |
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Gonesse, France, 95503 | |
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Rambouillet, France, 78120 | |
Germany | |
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Freiburg, Baden Wuerttemberg, Germany, 79098 | |
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Heidelberg, Baden Wuerttemberg, Germany, 69120 | |
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Heidenheim, Baden Wuerttemberg, Germany, 89518 | |
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Ladenburg, Baden Wuerttemberg, Germany, 68526 | |
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Mannheim, Baden Wuerttemberg, Germany, 68159 | |
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Mannheim, Baden Wuerttemberg, Germany, 68161 | |
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Ravensburg, Baden Wuerttemberg, Germany, 88212 | |
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Singen, Baden Wuerttemberg, Germany, 78224 | |
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Sinsheim, Baden Wuerttemberg, Germany, 74889 | |
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Stuttgart, Baden Wuerttemberg, Germany, 70176 | |
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Stuttgart, Baden Wuerttemberg, Germany, 70178 | |
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Stuttgart, Baden Wuerttemberg, Germany, 70182 | |
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Ulm, Baden Wuerttemberg, Germany, 89078 | |
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Alzenau, Bavaria, Germany, 63755 | |
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Bayreuth, Bayern, Germany, 95445 | |
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Bogen, Bayern, Germany, 94327 | |
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Erlangen, Bayern, Germany, 91054 | |
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Landshut, Bayern, Germany, 84028 | |
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Muenchen, Bayern, Germany, 81825 | |
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Neuburg, Bayern, Germany, 86633 | |
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Nuernberg, Bayern, Germany, 90451 | |
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Nürnberg, Bayern, Germany, 90419 | |
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Regensburg, Bayern, Germany, 93095 | |
Research Site | |
Unterhaching, Bayern, Germany, 82008 | |
Research Site | |
Wolfratshausen, Bayern, Germany, 82515 | |
Research Site | |
Wuerzburg, Bayern, Germany, 97080 | |
Research Site | |
Butzbach, Hessen, Germany, 35510 | |
Research Site | |
Eltville, Hessen, Germany, 65343 | |
Research Site | |
Erbach, Hessen, Germany, 64711 | |
Research Site | |
Eschwege, Hessen, Germany, 37269 | |
Research Site | |
Frankfurt, Hessen, Germany, 60313 | |
Research Site | |
Frankfurt, Hessen, Germany, 60488 | |
Research Site | |
Frankfurt, Hessen, Germany, 60528 | |
Research Site | |
Gelnhausen, Hessen, Germany, 63571 | |
Research Site | |
Giessen, Hessen, Germany, 35392 | |
Research Site | |
Gladenbach, Hessen, Germany, 35075 | |
Research Site | |
Kassel, Hessen, Germany, 34121 | |
Research Site | |
Wiesbaden, Hessen, Germany, 65183 | |
Research Site | |
Buchholz, Niedersachsen, Germany, 21244 | |
Research Site | |
Gottingen, Niedersachsen, Germany, 37073 | |
Research Site | |
Oldenburg, Niedersachsen, Germany, 26122 | |
Research Site | |
Stade, Niedersachsen, Germany, 21682 | |
Research Site | |
Aachen, Nordrhein Westfalen, Germany, 52062 | |
Research Site | |
Aachen, Nordrhein Westfalen, Germany, 52078 | |
Research Site | |
Bad Honnef, Nordrhein Westfalen, Germany, 53604 | |
Research Site | |
Bergisch-Gladbach, Nordrhein Westfalen, Germany, 51429 | |
Research Site | |
Bielefeld, Nordrhein Westfalen, Germany, 33647 | |
Research Site | |
Bochum, Nordrhein Westfalen, Germany, 44789 | |
Research Site | |
Bonn, Nordrhein Westfalen, Germany, 53111 | |
Research Site | |
Duesseldorf, Nordrhein Westfalen, Germany, 40211 | |
Research Site | |
Essen, Nordrhein Westfalen, Germany, 45138 | |
Research Site | |
Hagen, Nordrhein Westfalen, Germany, 58095 | |
Research Site | |
Koeln, Nordrhein Westfalen, Germany, 50935 | |
Research Site | |
Köln, Nordrhein Westfalen, Germany, 51063 | |
Research Site | |
Remscheid, Nordrhein Westfalen, Germany, 42853 | |
Research Site | |
Siegen, Nordrhein Westfalen, Germany, 57076 | |
Research Site | |
Willich, Nordrhein Westfalen, Germany, 47877 | |
Research Site | |
Wuppertal, Nordrhein Westfalen, Germany, 42284 | |
Research Site | |
Frankenthal, Rheinland Pfalz, Germany, 67227 | |
Research Site | |
Kandel, Rheinland Pfalz, Germany, 76870 | |
Research Site | |
Katzenelnbogen, Rheinland Pfalz, Germany, 56368 | |
Research Site | |
Rülzheim, Rheinland Pfalz, Germany, 76761 | |
Research Site | |
Trier, Rheinland Pfalz, Germany, 54292 | |
Research Site | |
Halle, Sachsen Anhalt, Germany, 06120 | |
Research Site | |
Magdeburg, Sachsen Anhalt, Germany, 39120 | |
Research Site | |
Chemnitz, Sachsen, Germany, 09117 | |
Research Site | |
Gorlitz, Sachsen, Germany, 02828 | |
Research Site | |
Leipzig, Sachsen, Germany, 04103 | |
Research Site | |
Leipzig, Sachsen, Germany, 04229 | |
Research Site | |
Wermsdorf, Sachsen, Germany, 04779 | |
Research Site | |
Kiel, Schleswig Holstein, Germany, 24105 | |
Research Site | |
Eisenach, Thueringen, Germany, 99817 | |
Research Site | |
Erfurt, Thueringen, Germany, 99096 | |
Research Site | |
Jena, Thueringen, Germany, 07747 | |
Research Site | |
Berlin, Germany, 10713 | |
Research Site | |
Berlin, Germany, 10961 | |
Research Site | |
Berlin, Germany, 12099 | |
Research Site | |
Berlin, Germany, 12163 | |
Research Site | |
Berlin, Germany, 13347 | |
Research Site | |
Berlin, Germany, 13465 | |
Research Site | |
Hamburg, Germany, 20249 | |
Research Site | |
Hamburg, Germany, 21149 | |
Research Site | |
Neusäß, Germany, 86356 | |
Hungary | |
Research Site | |
Budapest, Hungary, 1086 | |
Research Site | |
Budapest, Hungary, 1106 | |
Research Site | |
Budapest, Hungary, 1145 | |
Research Site | |
Eger, Hungary, 3300 | |
Research Site | |
Gyor, Hungary, 9024 | |
Research Site | |
Miskolc, Hungary, 3526 | |
Research Site | |
Szeged, Hungary, 6725 | |
Research Site | |
Tatabanya, Hungary, 2800 | |
Research Site | |
Zalaegerszeg, Hungary, 8900 | |
Ireland | |
Research Site | |
Dublin, Ireland, D04 N2E0 | |
Research Site | |
Dublin, Ireland, D09 V2N0 | |
Italy | |
Research Site | |
Torrette, Ancona, Italy, 60126 | |
Research Site | |
Montichiari, Brescia, Italy, 25018 | |
Research Site | |
Pozzilli, Isernia, Italy, 86077 | |
Research Site | |
Legnano, Milano, Italy, 20025 | |
Research Site | |
Fidenza, Parma, Italy, 43036 | |
Research Site | |
Orbassano, Torino, Italy, 10043 | |
Research Site | |
Gallarate, Varese, Italy, 21013 | |
Research Site | |
Bari, Italy, 70124 | |
Research Site | |
Bergamo, Italy, 24127 | |
Research Site | |
Bologna, Italy, 40139 | |
Research Site | |
Cagliari, Italy, 09126 | |
Research Site | |
Catanzaro, Italy, 88100 | |
Research Site | |
Genova, Italy, 16132 | |
Research Site | |
Messina, Italy, 98125 | |
Research Site | |
Milano, Italy, 20132 | |
Research Site | |
Modena, Italy, 41126 | |
Research Site | |
Napoli, Italy, 80131 | |
Research Site | |
Palermo, Italy, 90127 | |
Research Site | |
Palermo, Italy, 90146 | |
Research Site | |
Parma, Italy, 43126 | |
Research Site | |
Pavia, Italy, 27100 | |
Research Site | |
Perugia, Italy, 06156 | |
Research Site | |
Pordenone, Italy, 33170 | |
Research Site | |
Reggio Emilia, Italy, 42100 | |
Research Site | |
Roma, Italy, 00152 | |
Research Site | |
Roma, Italy, 00161 | |
Research Site | |
Roma, Italy, 00168 | |
Research Site | |
Roma, Italy, 00189 | |
Netherlands | |
Research Site | |
Amsterdam, Netherlands, 1091 AC | |
Research Site | |
Arnhem, Netherlands, 6815 AD | |
Research Site | |
Breda, Netherlands, 4818 CK | |
Research Site | |
Eindhoven, Netherlands, 5623 EJ | |
Research Site | |
Geldrop, Netherlands, 5664 EH | |
Research Site | |
Geleen, Netherlands, 6162 BG | |
Research Site | |
Hoorn, Netherlands, 1624 NP | |
Research Site | |
Leeuwarden, Netherlands, 8934 AD | |
Research Site | |
Leiden, Netherlands, 2334 CK | |
Research Site | |
Nieuwegein, Netherlands, 3435 CM | |
Research Site | |
Nijmegen, Netherlands, 6532 SZ | |
Research Site | |
Tilburg, Netherlands, 5042 AD | |
Research Site | |
Venlo, Netherlands, 5912 BL | |
New Zealand | |
Research Site | |
Christchurch, New Zealand, 8011 | |
Research Site | |
Dunedin, New Zealand, 9016 | |
Research Site | |
Hamilton, New Zealand, 3200 | |
Norway | |
Research Site | |
Bodø, Norway, 8005 | |
Research Site | |
Namsos, Norway, 7801 | |
Poland | |
Research Site | |
Ochojec, Katowice, Poland, 40-635 | |
Research Site | |
Bialystok, Poland, 15-276 | |
Research Site | |
Bydgoszcz, Poland, 85-681 | |
Research Site | |
Gdansk, Poland, 80-803 | |
Research site | |
Glogow Malopolski, Poland, 36-060 | |
Research Site | |
Grudziadz, Poland, 86-300 | |
Research site | |
Katowice, Poland, 40-571 | |
Research Site | |
Katowice, Poland, 40-752 | |
Research Site | |
Konskie, Poland, 26-200 | |
Research site | |
Konstancin-Jeziorna, Poland, 05-510 | |
Research Site | |
Krakow, Poland, 31-503 | |
Research site | |
Krakow, Poland, 31-637 | |
Research Site | |
Lublin, Poland, 20-954 | |
Research Site | |
Olsztyn, Poland, 10-561 | |
Research Site | |
Poznan, Poland, 60-355 | |
Research Site | |
Warszawa, Poland, 02-091 | |
Research Site | |
Warszawa, Poland, 02-957 | |
Research Site | |
Warszawa, Poland, 04-749 | |
Research Site | |
Zabrze, Poland, 41-800 | |
Portugal | |
Research Site | |
Amadora, Portugal, 2720-276 | |
Research Site | |
Braga, Portugal, 4710-243 | |
Research Site | |
Guimarães, Portugal, 4835-044 | |
Research Site | |
Matosinhos, Portugal, 4454-509 | |
Research Site | |
Penafiel, Portugal, 4560-007 | |
Research Site | |
Santarém, Portugal, 2005-177 | |
Research Site | |
Viana do Castelo, Portugal, 4901-858 | |
Research Site | |
Vila Nova de Gaia, Portugal, 4434-502 | |
Puerto Rico | |
Research Site | |
Guaynabo, Puerto Rico, 00968 | |
Research Site | |
San Juan, Puerto Rico, 00921 | |
Slovakia | |
Research Site | |
Banska Bystrica, Slovakia, 97517 | |
Research Site | |
Bratislava, Slovakia, 82101 | |
Research Site | |
Bratislava, Slovakia, 83101 | |
Research site | |
Martin, Slovakia, 03659 | |
Research Site | |
Nitra, Slovakia, 95001 | |
Research Site | |
Presov, Slovakia, 08081 | |
Research Site | |
Ruzomberok, Slovakia, 03426 | |
Research Site | |
Trencin, Slovakia, 91101 | |
Research Site | |
Trnava, Slovakia, 917 75 | |
Spain | |
Research Site | |
Gijon, Asturias, Spain, 33206 | |
Research Site | |
Palma de Mallorca, Baleares, Spain, 07010 | |
Research Site | |
Badalona, Barcelona, Spain, 08916 | |
Research Site | |
L'Hospitalet de Llobregat, Barcelona, Spain, 08907 | |
Research Site | |
Santander, Cantabria, Spain, 38003 | |
Research Site | |
Santiago de Compostela, La Coruña, Spain, 15706 | |
Research Site | |
Santa Cruz de Tenerife, Tenerife, Spain, 38010 | |
Research Site | |
Alzira, Valencia, Spain, 46600 | |
Research Site | |
Avila, Spain, 05004 | |
Research Site | |
Cádiz, Spain, 11009 | |
Research Site | |
Granada, Spain, 18014 | |
Research Site | |
Huelva, Spain, 21080 | |
Research Site | |
Jaén, Spain, 23007 | |
Research Site | |
Madrid, Spain, 28006 | |
Research Site | |
Murcia, Spain, 30008 | |
Research Site | |
Pontevedra, Spain, 36071 | |
Switzerland | |
Research Site | |
Bern, Switzerland, 3010 | |
Research Site | |
Lausanne, Switzerland, CH-1011 | |
Research Site | |
Lugano, Switzerland, 6900 | |
United Kingdom | |
Research Site | |
Bristol, Avon, United Kingdom, BS10 5NB | |
Research Site | |
Exeter, Devon, United Kingdom, EX2 5DW | |
Research Site | |
Plymouth, Devon, United Kingdom, PL6 8DH | |
Research Site | |
Torquay, Devon, United Kingdom, TQ2 7AA | |
Research Site | |
Salford, Greater Manchester, United Kingdom, M6 8HD | |
Research Site | |
Basingstoke, Hampshire, United Kingdom, RG24 9NA | |
Research Site | |
Southampton, Hampshire, United Kingdom, SO16 6YD | |
Research Site | |
Leicester, Leicestershire, United Kingdom, LE5 4PW | |
Research Site | |
Edinburgh, Lothian Region, United Kingdom, EH4 2XU | |
Research Site | |
Liverpool, Merseyside, United Kingdom, L9 7LJ | |
Research Site | |
Norwich, Norfolk, United Kingdom, NR4 7UY | |
Research Site | |
Nottingham, Nottinghamshire, United Kingdom, NG7 2UH | |
Research Site | |
Glasgow, Strathclyde, United Kingdom, G51 4TF | |
Research Site | |
Dundee, Tayside Region, United Kingdom, DD1 9SY | |
Research Site | |
Newcastle upon Tyne, Tyne & Wear, United Kingdom, NE4 5PL | |
Research Site | |
Birmingham, West Midlands, United Kingdom, B15 2GB | |
Research Site | |
Leeds, West Yorkshire, United Kingdom, LS1 3EX | |
Research Site | |
Belfast, United Kingdom, BT16 0RH | |
Research Site | |
Swansea, United Kingdom, SA6 6NL |
Study Director: | Medical Director | Biogen |
Responsible Party: | Biogen |
ClinicalTrials.gov Identifier: | NCT02047097 |
Other Study ID Numbers: |
109MS401 |
First Posted: | January 28, 2014 Key Record Dates |
Last Update Posted: | May 24, 2023 |
Last Verified: | May 2023 |
Multiple Sclerosis Sclerosis Pathologic Processes Demyelinating Autoimmune Diseases, CNS Autoimmune Diseases of the Nervous System Nervous System Diseases Demyelinating Diseases |
Autoimmune Diseases Immune System Diseases Dimethyl Fumarate Dermatologic Agents Immunosuppressive Agents Immunologic Factors Physiological Effects of Drugs |