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Trial record 1 of 2 for:    MATCH-R
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A Prospective Trial to Study the Evolution of Clonal Architecture of Tumors From Patients Treated With Molecular Targeted Agents (MATCH-R)

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ClinicalTrials.gov Identifier: NCT02517892
Recruitment Status : Active, not recruiting
First Posted : August 7, 2015
Last Update Posted : August 22, 2023
Sponsor:
Information provided by (Responsible Party):
Gustave Roussy, Cancer Campus, Grand Paris

Study Description
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Brief Summary:

This is a prospective study to identify molecular mechanisms of acquired resistance to targeted therapies in patients with unresectable or metastatic cancer.

This is a protocol to study clinical characteristics and biopsy tissue of patients with oncogene-driven cancer who have had previous clinical response to targeted therapy and subsequently experience progression of disease. The tissues and other specimens will be used to carry out laboratory studies to explore the molecular basis of acquired resistance to targeted therapies.


Condition or disease Intervention/treatment Phase
Metastatic Oncogen-driven Cancer Procedure: Biopsy Not Applicable

Study Design
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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 1500 participants
Allocation: N/A
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Other
Official Title: A Prospective Trial to Study the Evolution of Clonal Architecture of Tumors From Patients Treated With Molecular Targeted Agents
Actual Study Start Date : December 18, 2014
Estimated Primary Completion Date : November 18, 2023
Estimated Study Completion Date : March 2025
Arms and Interventions
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Arm Intervention/treatment
Experimental: Patients with metastatic oncogen-driven cancer Procedure: Biopsy


Outcome Measures
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Primary Outcome Measures :
  1. Type and frequency of molecular alterations in resistant tumors using whole exome sequencing [ Time Frame: 30 days after inclusion ]

Eligibility Criteria
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Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

Patients diagnosed with confirmed cancer and who fulfill the following eligibility criteria will be considered eligible for this study:

  1. Patient affiliated to a social security regimen
  2. Patients scheduled to receive anticancer agents or currently receiving anticancer agents
  3. Tumor lesion accessible to core biopsies (malignant effusions can represent an alternative)
  4. Patient who is fully informed, able to comply with the protocol and who signed the informed consent.
  5. Availability of initial tumor material (ideally frozen, or non-Bouin fixed paraffin embedded material) acquired before exposure to the targeted therapy Note: Patients may have received other treatments since treatment with targeted therapies including radiation or chemotherapy, before undergoing the study biopsy.

Exclusion Criteria:

1. Coagulation abnormality prohibiting a biopsy

Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02517892


Locations
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France
Gustave Roussy Cancer Campus Grand Paris
Villejuif, Val De Marne, France, 94805
Sponsors and Collaborators
Gustave Roussy, Cancer Campus, Grand Paris
More Information
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Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

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Responsible Party: Gustave Roussy, Cancer Campus, Grand Paris
ClinicalTrials.gov Identifier: NCT02517892    
Other Study ID Numbers: 2014-A01147-40
2014/2144 ( Other Identifier: CSET number )
First Posted: August 7, 2015    Key Record Dates
Last Update Posted: August 22, 2023
Last Verified: August 2023