Colchicine Cardiovascular Outcomes Trial (COLCOT) (COLCOT)

• ClinicalTrials.gov Identifier: NCT02551094
• Recruitment Status: Completed
• First Posted: September 16, 2015
• Results First Posted: October 19, 2020
• Last Update Posted: October 19, 2020
• Sponsor: Montreal Heart Institute
• Information provided by (Responsible Party): Montreal Heart Institute

Study Description

Brief Summary:

The study evaluates whether long-term treatment with colchicine reduces rates of cardiovascular events in patients after myocardial infarction. Patients who have suffered a documented acute myocardial infarction within the last 30 days, are treated according to the national guidelines and after having completed any planned percutaneous revascularization procedures associated with their initial infarction will receive either colchicine (0.5 mg per day) or matching placebo (1:1 allocation ratio) for an estimated 2 years period or until the target of 301 primary endpoints has been reached.

Condition or disease	Intervention/treatment	Phase
Coronary Artery Disease; Myocardial Infarction	Drug: colchicine; Drug: colchicine placebo	Phase 3

Detailed Description:

Atherosclerosis is the most common cause of myocardial infarction, stroke and peripheral arterial disease. Research has clearly demonstrated that inflammation plays a key role in the initiation, progression and manifestations of atherosclerosis. Atherosclerotic lesions begin as an accumulation of lipid-laden cells (primarily macrophages) beneath the endothelium, and progress with the further accumulation of cells, connective-tissue elements, lipids and debris through immunological and inflammatory activation. Neutrophils and other inflammatory cells have been shown to invade culprit atherosclerotic lesions in acute coronary syndromes. It is likely that the inflammatory process is responsible for the high rate of cardiovascular events despite significant advances in the treatment of risk factors such as hypercholesterolemia and hypertension. It is vital to improve our understanding of the inflammatory nature of atherosclerotic disease and modify the inflammatory process with targeted therapies. Prospective cohort studies have consistently shown that high sensitivity C-reactive protein (hs-CRP) and several other biomarkers of inflammation are independently associated with increasing risk of future cardiovascular events in different populations. This together with animal models showing that reduced inflammation has anti-atherosclerotic effects, create the impetus to test the hypothesis that treatment of the underlying inflammatory process will contribute to improved cardiovascular clinical outcomes. Colchicine is an inexpensive, yet potent, anti-inflammatory drug approved for acute use in patients with gout and chronic use in patients with Familial Mediterranean Fever. The mechanism of action is through the inhibition of tubulin polymerization and potentially also through effects on cellular adhesion molecules and inflammatory chemokines. Colchicine may also have direct anti-inflammatory effects by inhibiting key inflammatory signaling networks known as the inflammasome and pro-inflammatory cytokines. Through the disruption of the cytoskeleton, colchicine is believed to suppress secretion of cytokines and chemokines as well as in vitro platelet aggregation. Considerable work has highlighted the potential of colchicine in the treatment of cardiovascular diseases mediated by pro-inflammatory processes. More recently colchicine has been evaluated for its effect on cardiovascular events in patients with coronary artery disease (CAD).

Study Design

• Study Type: Interventional (Clinical Trial)
• Actual Enrollment: 4745 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
• Primary Purpose: Prevention
• Official Title: Colchicine Cardiovascular Outcomes Trial (COLCOT)
• Actual Study Start Date: December 4, 2015
• Actual Primary Completion Date: July 17, 2019
• Actual Study Completion Date: July 17, 2019

Arms and Interventions

Arm	Intervention/treatment
Active Comparator: colchicine; 0.5 mg tablet of colchicine taken once a day	Drug: colchicine; 0.5 mg tablet taken once a day; Other Name: no other name
Placebo Comparator: colchicine placebo; 0.5 mg tablet of placebo taken once a day	Drug: colchicine placebo; sugar pill manufactured to mimic colchicine 0.5 mg tablet; Other Name: no other name

Outcome Measures

Primary Outcome Measures :

1. First Event of Cardiovascular Death, Resuscitated Cardiac Arrest, Acute Myocardial Infarction, Stroke, or Urgent Hospitalization for Angina Requiring Coronary Revascularization [ Time Frame: From randomization to occurence of first event, assessed up to 3.5 years ]
   The descriptive statistics are the number of participants having at least one of the composites of the primary endpoint.

Secondary Outcome Measures :

1. Death (Total Mortality) [ Time Frame: From randomization to death, assessed up to 3.5 years ]
   The descriptive statistics are the number of participants having deceased.
2. Cardiovascular Death [ Time Frame: From randomization to death, assessed up to 3.5 years ]
   The descriptive statistics are presented as the number of participants having had a cardiovascular death.
3. Resuscitated Cardiac Arrest [ Time Frame: From randomization to event, assessed up to 3.5 years ]
   The descriptive statistics are presented as the number of participants having had resuscitated cardiac arrest
4. Myocardial Infarction [ Time Frame: From randomization to event, assessed up to 3.5 years ]
   The descriptive statistics are presented as the number of participants having had myocardial infarction.
5. Stroke [ Time Frame: From randomization to event, assessed up to 3.5 years ]
   The descriptive statistics are presented as the number of participants having had a stroke.
6. Urgent Hospitalization for Angina Requiring Coronary Revascularization [ Time Frame: From randomization to event, assessed up to 3.5 years ]
   The descriptive statistics are presented as the number of participants having had urgent hospitalization for angina requiring coronary revascularization.
7. First Event of Cardiovascular Death, Resuscitated Cardiac Arrest, Acute MI or Stroke. [ Time Frame: From randomization to occurence of first event, assessed up to 3.5 years ]
   The descriptive statistics are presented as the number of participants having had a first event of cardiovascular death, resuscitated cardiac arrest, acute MI or stroke.

Other Outcome Measures:

1. First Event of Deep Venous Thrombosis or Pulmonary Embolus [ Time Frame: From randomization to occurence of first event, assessed up to 3.5 years ]
   The descriptive statistics are presented as the number of participants having had a first event of deep venous thrombosis or pulmonary embolus.
2. Atrial Fibrillation [ Time Frame: From randomization to event, assessed up to 3.5 years ]
   The descriptive statistics are presented as the number of participants having had atrial fibrillation.
3. Heart Failure Hospitalization [ Time Frame: From randomization to event, assessed up to 3.5 years ]
   The descriptive statistics are presented as the number of participants having had heart failure hospitalization.
4. Coronary Revascularization [ Time Frame: From randomization to event, assessed up to 3.5 years ]
   The descriptive statistics are presented as the number of participants having had coronary revascularization.

Eligibility Criteria

• Ages Eligible for Study: 18 Years and older (Adult, Older Adult)
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Criteria

Inclusion Criteria:

• Males and females of at least 18 years of age capable and willing to provide informed consent
• Patient must have suffered a documented acute myocardial infarction within the last 30 days
• Patient must be treated according to national guidelines (including anti-platelet therapy, statin, renin-angiotensin-aldosterone system inhibitor (preferably angiotensin-converting enzyme) and beta-blocker when indicated)
• Patient must have completed any planned percutaneous revascularization procedures associated with his or her qualifying myocardial infarction
• Female patient is either not of childbearing potential, defined as postmenopausal for at least one year or surgically sterile, or is of childbearing potential and practicing at least one method of contraception and preferably two complementary forms of contraception
• Patient is judged to be in good general health as determined by the principal investigator
• Patient must be able and willing to comply with the requirements of this study protocol

Exclusion Criteria:

• Patient with a poorly controlled medical condition, such as New York Heart Association Class III-IV heart failure, a left ventricular ejection fraction of less than 35%, recent stroke (within the past 3 months), or any other condition which in the opinion of the investigator, would put the patient at risk if participating in this study
• Patient with a Type 2 index MI (secondary to ischemic imbalance)
• Patient with a prior coronary artery bypass graft within the past 3 years, or planned
• Patient currently in cardiogenic shock or with hemodynamic instability
• Patient with a history of cancer or lymphoproliferative disease within the last 3 years other than a successfully treated non-metastatic cutaneous squamous cell or basal cell carcinoma and or localized carcinoma in situ of the cervix
• Patient with inflammatory bowel disease (Crohn's disease or ulcerative colitis) or patient with chronic diarrhea
• Patient with pre-existent progressive neuromuscular disease or patient with creatine phosphokinase level greater than 3 times the upper limit of normal (unless due to myocardial infarction which is allowed) as measured within the past 30 days and determined to be non-transient through repeat testing
• Patient with any of the following as measured within the past 30 days, and determined to be non-transient through repeat testing: hemoglobin less than 115 grams/L, white blood cell count less than 3.0 X 10(9)/L,platelet count less than 110 X 10(9)/L, alanine aminotransferase greater than 3 times the upper limit of normal, total bilirubin greater than 2 times the upper limit of normal (unless due to Gilbert syndrome, which is allowed), creatinine greater than 2 times the upper limit of normal
• Patient with a history of cirrhosis, chronic active hepatitis or sever hepatic disease
• Female patient who is pregnant, or breast-feeding or is considering becoming pregnant during the study or for 6 months after the last dose of study medication
• Patient with a history of clinically significant drug or alcohol abuse in the last year
• Patient is currently using or plan to begin chronic systemic steroid therapy (oral or intravenous) during the study (topical or inhaled steroids are allowed)
• Patient currently taking colchicine for other indications (mainly chronic indications represented by Familial Mediterranean Fever or gout); there is no wash-out period required for patients who have been treated with colchicine and stopped treatment prior to enrollment
• Patient with history of an allergic reaction or significant sensitivity to colchicine
• Patient who has used an investigational chemical agent less than 30 days or 5 half-lives prior to the screening visit (whichever is longer)
• Patient is considered by he investigator, for any reason, to be an unsuitable candidate for the study

Contacts and Locations

Locations

Canada, Quebec

Montreal Heart Institute

Montreal, Quebec, Canada, H1T1C8

Sponsors and Collaborators

Montreal Heart Institute

Investigators

• Principal Investigator: Jean-Claude Tardif, MD; Montreal Heart Institute
• Study Director: Andreas Orfanos, MD; Montreal Health Innovations Coordinating Centre

  Study Documents (Full-Text)

Documents provided by Montreal Heart Institute:

Statistical Analysis Plan  [PDF] August 28, 2019

Study Protocol  [PDF] November 15, 2018

More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Bouabdallaoui N, Tardif JC, Waters DD, Pinto FJ, Maggioni AP, Diaz R, Berry C, Koenig W, Lopez-Sendon J, Gamra H, Kiwan GS, Blondeau L, Orfanos A, Ibrahim R, Gregoire JC, Dube MP, Samuel M, Morel O, Lim P, Bertrand OF, Kouz S, Guertin MC, L'Allier PL, Roubille F. Time-to-treatment initiation of colchicine and cardiovascular outcomes after myocardial infarction in the Colchicine Cardiovascular Outcomes Trial (COLCOT). Eur Heart J. 2020 Nov 7;41(42):4092-4099. doi: 10.1093/eurheartj/ehaa659.

Tardif JC, Kouz S, Waters DD, Bertrand OF, Diaz R, Maggioni AP, Pinto FJ, Ibrahim R, Gamra H, Kiwan GS, Berry C, Lopez-Sendon J, Ostadal P, Koenig W, Angoulvant D, Gregoire JC, Lavoie MA, Dube MP, Rhainds D, Provencher M, Blondeau L, Orfanos A, L'Allier PL, Guertin MC, Roubille F. Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction. N Engl J Med. 2019 Dec 26;381(26):2497-2505. doi: 10.1056/NEJMoa1912388. Epub 2019 Nov 16.

• Responsible Party: Montreal Heart Institute
• ClinicalTrials.gov Identifier: NCT02551094
• Other Study ID Numbers: MHIPS-003
• First Posted: September 16, 2015
• Results First Posted: October 19, 2020
• Last Update Posted: October 19, 2020
• Last Verified: September 2020

Additional relevant MeSH terms:

Coronary Artery Disease; Myocardial Infarction; Infarction; Ischemia; Pathologic Processes; Necrosis; Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Colchicine; Gout Suppressants; Antirheumatic Agents; Tubulin Modulators; Antimitotic Agents; Mitosis Modulators; Molecular Mechanisms of Pharmacological Action; Antineoplastic Agents