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Resistance Exercise and Cannabis Use

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ClinicalTrials.gov Identifier: NCT03867786
Recruitment Status : Not yet recruiting
First Posted : March 8, 2019
Last Update Posted : January 20, 2023
Sponsor:
Information provided by (Responsible Party):
Gwendolyn Thomas, Penn State University

Study Description
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Brief Summary:
Cannabis is the most widely used illicit drug and rates of hazardous use, and cannabis use disorders (CUDs), have continued to rise in recent years. The highest rates of use and CUDs are seen in young adults (20 - 24 years old) with more than 50% of young adults reporting lifetime use of cannabis, 35% report use in the past year, and 20% report use in the past month. Increased exposure produces higher risk for detrimental psychological and behavioral effects of cannabis use. Given this increased prevalence of cannabis use and associated risks, identifying effective behavioral strategies that reduce cannabis craving, negative psychological effects, and alter neurobiological mechanisms underlying problematic cannabis use are an avenue of needed research. Exercise, particularly resistance exercise, is a behavioral intervention with considerable potential as an adjunctive treatment for CUD.

Condition or disease Intervention/treatment Phase
Cannabis Use Disorder Behavioral: Exercise Behavioral: Video Control Not Applicable

Detailed Description:

Cannabis is the most widely used illicit drug and rates of hazardous use, and cannabis use disorders (CUDs), have continued to rise in recent years. The highest rates of use and CUDs are seen in young adults (20 - 24 years old) with more than 50% of young adults reporting lifetime use of cannabis, 35% report use in the past year, and 20% report use in the past month. Increased exposure produces higher risk for detrimental psychological and behavioral effects of cannabis use. Given this increased prevalence of cannabis use and associated risks, identifying effective behavioral strategies that reduce cannabis craving, negative psychological effects, and alter neurobiological mechanisms underlying problematic cannabis use are an avenue of needed research. Exercise, particularly resistance exercise, is a behavioral intervention with considerable potential as an adjunctive treatment for CUD.

The aims of this proposal seek to address these issues by implementing acute resistance exercise protocol in men and women who have cannabis use disorder. This proposal will: 1 examine the effect of an acute resistance exercise protocol on affect, stress, and compulsive urge to use in non-treatment seeking young adults with CUD 2.examine whether an acute resistance exercise session in individuals with CUD is associated with induced alterations in the appetitive/ reward hormone ghrelin These findings will inform the further development for exercise interventions for cannabis use disorder that can be used with the aim of supporting individuals with CUD reduce use and decrease the negative effects of withdrawal.

Study Design
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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 40 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: The Acute Effects of Resistance Exercise on Cannabis Use and Craving
Estimated Study Start Date : February 1, 2023
Estimated Primary Completion Date : August 31, 2023
Estimated Study Completion Date : December 1, 2024

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Marijuana

Arms and Interventions
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Arm Intervention/treatment
Experimental: Exercise Condition
Participants will undergo a 40 minute exercise protocol
 Behavioral: Exercise
Participants will complete an acute exercise visit.
Active Comparator: Video Control Condition
Participants will view a 40 minute nature video
 Behavioral: Video Control
Participants will complete a video control visit.


Outcome Measures
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Primary Outcome Measures :
  1. Cannabis Craving [ Time Frame: change from baseline ]
    Craving Marijuana Craving Questionnaire (MCQ) The 45-item MCQ is a multi-dimensional questionnaire that assesses marijuana craving. It is based on the the Cocaine Craving Questionnaire and uses items that touch on four specific constructs characterizing craving for marijuana: (1) compulsivity, an inability to control marijuana use; (2) emotionality, use of marijuana in anticipation of relief from withdrawal or negative mood; (3) expectancy, anticipation of positive outcomes from smoking marijuana; and (4) purposefulness, intention and planning to use marijuana for positive outcomes. Each item is rated on a seven-point Likert-type scale ranging from "strongly agree to strongly disagree"

  2. Cannabis Craving [ Time Frame: Change from baseline ]
    Total Ghrelin as measured by 0.5mL plasma

  3. Cannibis Consumption [ Time Frame: change from Baseline ]
    endocannabinoid N-arachidonoylethanolamine (AEA)


Eligibility Criteria
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Ages Eligible for Study:   18 Years to 30 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  1. Healthy individuals between the ages of 18-30 years who currently meet for a moderate or severe cannabis use disorder according to DSM-5 criteria.
  2. Untrained (no structured exercise program for at least the previous 6 months) as verified by self-report on a physical activity form.
  3. No previous bone or muscle problems or previous injuries that would prevent free movement about the shoulder, hip, knee or ankle, or increase the risk of discomfort or injury during exercise. No ongoing back problems.
  4. No known endocrine disorders (including, but not limited to Hyperthyroidism, Hypothyroidism, Hyperparathyroidism, Cushing's Syndrome, Diabetes mellitus, metabolic syndrome or other inflammatory disorders).
  5. No history of blood clotting disorders.
  6. Able to read English and complete study assessments
  7. Voluntarily provide informed consent and sign the informed consent document.
  8. Able to provide negative toxicology screenings for substances, except for cannabis, at intake.

Exclusion Criteria:

  1. Meet current criteria for a moderate or severe substance use disorder for any other substance besides cannabis
  2. Have any current psychiatric disorders with acute symptoms (i.e., psychosis, suicidal, homicidal, current mania).
  3. Younger or older than the specified age range of 18-30.
  4. Any endocrine, bone, muscle problems, previous injuries, back problems, or blood clotting disorders.
  5. Cardiac and severe respiratory illnesses (i.e. arrhythmias, enlarged heart, COPD) -
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03867786


Contacts
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Contact: Gwendolyn Thomas, PhD 8148633172 gat112@psu.edu

Sponsors and Collaborators
Penn State University
More Information
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Responsible Party: Gwendolyn Thomas, Assistant Research Professor, Kinesiology, Penn State University
ClinicalTrials.gov Identifier: NCT03867786    
Other Study ID Numbers: 12345
First Posted: March 8, 2019    Key Record Dates
Last Update Posted: January 20, 2023
Last Verified: January 2023
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Gwendolyn Thomas, Penn State University:
Resistance Exercise Neurobiological Mechanisms
Additional relevant MeSH terms:
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Marijuana Abuse
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders