Zanubrutinib and Venetoclax in CLL (ZANU-VEN)

• ClinicalTrials.gov Identifier: NCT05168930
• Recruitment Status: Recruiting
• First Posted: December 23, 2021
• Last Update Posted: January 9, 2024
• Sponsor: Dana-Farber Cancer Institute
• Collaborator: BeiGene
• Information provided by (Responsible Party): Inhye Ahn, Dana-Farber Cancer Institute

Study Description

Brief Summary:

This study is being done to test the effectiveness of zanubrutinib in combination with venetoclax in participants with previously treated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).

Condition or disease	Intervention/treatment	Phase
Chronic Lymphocytic Leukemia (CLL); Small Lymphocytic Lymphoma (SLL)	Drug: Venetoclax; Drug: Zanubrutinib	Phase 2

Detailed Description:

This is an open-label, non-randomized phase 2 trial assessing the combination of zanubrutinib and venetoclax in adult participants with CLL or SLL who have relapsed after at least one prior therapy.

Participants will receive study treatment for 15 months initially. There is an option for an additional 12 months of re-treatment with study therapy at the time of disease recurrence. Participants will be followed for 36 months after they discontinue the study drugs.

The study will enroll up to 45 participants. BeiGene Ltd. is providing funding for the trial and the study drug zanubrutinib.

Study Design

• Study Type: Interventional (Clinical Trial)
• Estimated Enrollment: 45 participants
• Allocation: Non-Randomized
• Intervention Model: Parallel Assignment
• Masking: None (Open Label)
• Primary Purpose: Treatment
• Official Title: A Phase 2 Trial of Zanubrutinib and Venetoclax in Previously Treated CLL/SLL Patients
• Actual Study Start Date: February 18, 2022
• Estimated Primary Completion Date: October 28, 2025
• Estimated Study Completion Date: October 28, 2028

Arms and Interventions

Arm	Intervention/treatment
Experimental: Cohort A: BTKi and BCL2i naive; Participants who have never received a BTK inhibitor or a BCL-2 inhibitor	Drug: Venetoclax; C4-15; Other Name: Venclexta; Drug: Zanubrutinib; C1-15; Other Name: Brukinsa
Experimental: Cohort B: BTKi or BCL2i exposed without disease progression; Participants who have received prior treatment with a BTK or BCL-2 inhibitor and discontinued treatment for any reason other than disease progression	Drug: Venetoclax; C4-15; Other Name: Venclexta; Drug: Zanubrutinib; C1-15; Other Name: Brukinsa
Experimental: Cohort C: BTKi exposed and with disease progression; Participants who experienced disease progression on a prior BTK inhibitor. Participants with BTK C481X mutation at enrollment will be excluded.	Drug: Venetoclax; C4-15; Other Name: Venclexta; Drug: Zanubrutinib; C1-15; Other Name: Brukinsa

Outcome Measures

Primary Outcome Measures :

1. Rate of undetectable minimal residual disease (uMRD) [ Time Frame: At the end of cycle 15 (each cycle is 28 days) ]
   Assessed by flow cytometry (FC)

Secondary Outcome Measures :

1. Overall response Rate (ORR) [ Time Frame: At the end of cycle 15 (each cycle is 28 days) ]
   Assessed by 2018 IWCLL criteria
2. Complete Response (CR) Rate [ Time Frame: At the end of cycle 15 (each cycle is 28 days) ]
   Assessed by 2018 IWCLL criteria
3. Percentage of undetectable minimal residual disease (uMRD) in bone marrow with CR [ Time Frame: At the end of cycle 15 (each cycle is 28 days) ]
   Assessed by flow cytometry (FC)
4. Percentage of uMRD in peripheral blood [ Time Frame: After cycle 15At the end of cycle 15 (each cycle is 28 days) ]
   Assessed by flow cytometry (FC)
5. Progression-free survival (PFS) [ Time Frame: 1 and 3 years after treatment initiation ]
   Time since treatment initiation and alive without disease progression
6. Overall survival (OS) [ Time Frame: 1 and 3 years after treatment initiation ]
   Time since treatment initiation and alive

Eligibility Criteria

• Ages Eligible for Study: 18 Years and older (Adult, Older Adult)
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Criteria

Inclusion Criteria

• Confirmed diagnosis of CLL or SLL as per 2018 International Workshop on CLL (IWCLL) criteria.
• Participants must have relapsed after at least one prior line of therapy and must currently require therapy by 2019 IWCLL criteria.
• For enrollment to Cohort A: Participants must be covalent BTK and BCL-2 inhibitor naïve. Participants who have received prior therapy with a covalent BTK or BCL-2 inhibitor are not eligible, including but not limited to prior treatment with ibrutinib or acalabrutinib.
• For enrollment to Cohort B: Participants must have had prior treatment with a BTK inhibitor or a BCL-2 inhibitor, but not both, and must not have experienced disease progression as defined by iwCLL criteria while receiving therapy.
• For enrollment to Cohort C: participants must have a disease that progressed during therapy with a covalent BTK inhibitor, not including zanubrutinib.
• Age ≥ 18 years. Because no dosing or adverse event data are currently available on the use of zanubrutinib and venetoclax in participants < 18 years of age and CLL/SLL is extremely rare in this population, children are excluded from this study.
• ECOG performance status ≤ 2 (Karnofsky ≥ 60%, see Appendix A).

• Participants must have adequate organ function as defined below:

  • Platelet count ≥ 20,000/mcL
  • Total bilirubin ≤ 2 × institutional upper limit of normal (ULN) (unless due to controlled hemolysis, Gilbert's disease, or is of non-hepatic origin)
  • AST (SGOT) and ALT (SGPT) ≤ 4 × institutional ULN
  • Serum Creatinine ≤ 1.5 × institutional ULN, OR
  • Calculated creatinine clearance ≥ 50 mL/min (as calculated by the Cockcroft-Gault formula)
• The effects of zanubrutinib or venetoclax on the developing human fetus are unknown. For this reason and because anti-cancer agents are known to be teratogenic, women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately. Men treated or enrolled on this protocol must also agree to use adequate contraception prior to the study, for the duration of study participation, and 4 months after completion of study agent administration.
• Ability to understand and the willingness to sign a written informed consent document.
• Ability to swallow and retain oral medication.

Exclusion Criteria:

• Known BTK C481X mutation.
• For enrollment to Cohort B: participants who have received prior treatment with both a BTK inhibitor and BCL-2 inhibitor.
• Participants who have had previous anti-cancer therapy (e.g., chemotherapy, radiotherapy, immunotherapy, biologic therapy, hormonal therapy, surgery, investigational agents, and/or tumor embolization) within 2 weeks of Cycle 1 Day 1 with the following exceptions:
• Hormonal therapy given in the adjuvant setting
• Corticosteroid therapy (prednisone or equivalent ≤ 20 mg daily) is allowed as clinically warranted as long as the dose is stabilized at least for 7 days prior to initial dosing. Topical, inhaled, intra-articular, or ophthalmologic corticosteroids are permitted
• Participants enrolling to Cohort C may remain on prior BTK inhibitor therapy up until 2 days prior to Cycle 1 Day 1
• History of a prior allogeneic hematologic stem cell transplant.
• Participants with known central nervous system (CNS) involvement, because of their poor prognosis and because they often develop progressive neurologic dysfunction that would confound the evaluation of neurologic and other adverse events. Participants with no known history of CNS involvement are not required to undergo CT scan or lumbar puncture (LP) for trial eligibility unless the participant is symptomatic as judged by the treating investigator.
• Participants who are receiving any other investigational agents at the time of study entry.

• History of other malignancies, with the following exceptions:

  • Malignancy treated with curative intent and with no known active disease present for ≥ 2 years before the first dose of study drug and felt to be at low risk for recurrence by treating physician
  • Adequately treated non-melanoma skin cancer or lentigo maligna without evidence of disease
  • Adequately treated carcinoma in situ without evidence of disease
  • Low-risk prostate cancer on active surveillance
• Participants who have been vaccinated with live, attenuated vaccines < 4 weeks prior to Cycle 1 Day 1.
• Recent infection requiring intravenous antibiotics completed ≤ 7 days before the first dose of study drug, or any uncontrolled active systemic infection.
• Known bleeding disorders (e.g. von Willebrand's disease) or hemophilia.
• History of stroke, intracranial hemorrhage, or recent major bleed within 6 months prior to study entry.
• Participants who require warfarin or other vitamin K antagonists for anticoagulation (other anticoagulants are allowed with approval from the overall principal investigator).
• Participants who are known at the time of study entry to require concomitant treatment with any medications or substances that are moderate or strong CYP3A inhibitors or inducers. Because the lists of these agents are constantly changing, it is important to regularly consult a frequently-updated medical reference. As part of the enrollment/informed consent procedures, the participant will be counseled on the risk of interactions with other agents, and what to do if new medications need to be prescribed or if the participant is considering a new over-the-counter medicine or herbal product.
• Known history of human immunodeficiency virus (HIV), active hepatitis C virus (HCV), or hepatitis B virus (HBV).
• History of allergic reactions attributed to compounds of similar chemical or biologic composition to zanubrutinib or venetoclax.
• Participants with psychiatric illness/social situations that would limit compliance with study requirements.
• Pregnant women are excluded from this study because zanubrutinib and venetoclax are anti-cancer agents with the potential for teratogenic or abortifacient effects. Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with zanubrutinib or venetoclax, breastfeeding should be discontinued if the mother is treated with zanubrutinib or venetoclax.
• Participants with malabsorption syndrome, disease significantly affecting gastrointestinal function, or resection of the stomach or small bowel, symptomatic inflammatory bowel disease or ulcerative colitis, or partial or complete bowel obstruction.
• Currently active, clinically significant cardiovascular disease, such as uncontrolled arrhythmia or Class 3 or 4 congestive heart failure as defined by the New York Heart Association Functional Classification; or a history of myocardial infarction, unstable angina, or acute coronary syndrome within 6 months prior to study entry.
• Any life-threatening illness, medical condition, or organ system dysfunction that, in the treating investigator's opinion, could compromise the participant's safety or the integrity of the trial.
• Active and/or ongoing autoimmune anemia and/or autoimmune thrombocytopenia.

Contacts and Locations

Contacts

Contact: Megan Forsyth; 857-215-1405; megan_forsyth@dfci.harvard.edu

Locations

United States, Maine

New England Cancer Specialists; Recruiting

Scarborough, Maine, United States, 04074

Contact: Patricia Collins 207-303-3429 collip@newecs.org

Principal Investigator: John P Winters, III, MD

United States, Massachusetts

Beth Israel Deaconess Medical Center; Recruiting

Boston, Massachusetts, United States, 02215

Contact: Jon Arnason, MD

Principal Investigator: Jon Arnason, MD

Dana-Farber Cancer Institute; Recruiting

Boston, Massachusetts, United States, 02215

Contact: Inhye E Ahn, MD

Principal Investigator: Inhye E Ahn, MD

South Shore Hospital; Recruiting

South Weymouth, Massachusetts, United States, 02190

Contact: Nicole Hixon, RN Nicole_Hixon@DFCI.HARVARD.EDU

Principal Investigator: Nancy Kaddis, MD, MPH

Sponsors and Collaborators

Dana-Farber Cancer Institute

BeiGene

Investigators

• Principal Investigator: Inhye E Ahn, MD; Dana-Farber Cancer Institute

More Information

• Responsible Party: Inhye Ahn, Principal Investigator, Dana-Farber Cancer Institute
• ClinicalTrials.gov Identifier: NCT05168930
• Other Study ID Numbers: 21-279
• First Posted: December 23, 2021
• Last Update Posted: January 9, 2024
• Last Verified: January 2024

Individual Participant Data (IPD) Sharing Statement:

• Plan to Share IPD: Yes
• Plan Description: The Dana-Farber / Harvard Cancer Center encourages and supports the responsible and ethical sharing of data from clinical trials. De-identified participant data from the final research dataset used in the published manuscript may only be shared under the terms of a Data Use Agreement. Requests may be directed to: [contact information for Sponsor Investigator or designee]. The protocol and statistical analysis plan will be made available on Clinicaltrials.gov only as required by federal regulation or as a condition of awards and agreements supporting the research.
• Supporting Materials: Study Protocol; Statistical Analysis Plan (SAP); Informed Consent Form (ICF)
• Time Frame: Data can be shared no earlier than 1 year following the date of publication
• Access Criteria: Contact the Belfer Office for Dana-Farber Innovations (BODFI) at innovation@dfci.harvard.edu

• Studies a U.S. FDA-regulated Drug Product: Yes
• Studies a U.S. FDA-regulated Device Product: No

Keywords provided by Inhye Ahn, Dana-Farber Cancer Institute:

Zanubrutinib; Venetoclax

Additional relevant MeSH terms:

Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Leukemia; Neoplasms by Histologic Type; Neoplasms; Hematologic Diseases; Lymphoproliferative Disorders; Lymphatic Diseases; Immunoproliferative Disorders; Immune System Diseases; Leukemia, B-Cell; Chronic Disease; Disease Attributes; Pathologic Processes; Venetoclax; Zanubrutinib; Antineoplastic Agents; Tyrosine Kinase Inhibitors; Protein Kinase Inhibitors; Enzyme Inhibitors; Molecular Mechanisms of Pharmacological Action