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Diet-induced Elevations in LDL-C and Progression of Atherosclerosis (Keto-CTA)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT05733325
Recruitment Status : Completed
First Posted : February 17, 2023
Last Update Posted : March 19, 2024
Sponsor:
Collaborator:
Citizen Science Foundation
Information provided by (Responsible Party):
Matthew J. Budoff, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

Brief Summary:
This is an observational study examining the progression of subclinical coronary atherosclerosis in healthy participants who have an elevated LDL-C (above 190mg/dl) secondary to diet not associated with genetic familial hypercholesterolemia (FH). This study participants are classified to be Lean-Mass-Hyper-Responder (LMHR).

Condition or disease
Hypercholesterolemia

Detailed Description:

This is an observational study examining the progression of subclinical coronary atherosclerosis in healthy participants who have an elevated LDL-C (above 190mg/dl) secondary to diet not associated with genetic familial hypercholesterolemia (FH). The investigator proposes to measure subclinical atherosclerosis as measured by low-dose prospective ECG-triggered cardiac computed tomographic angiography (CCTA) - in order to evaluate the rates of progression of atherosclerosis over 1 year. These participants will have voluntarily been eating a very low carbohydrate or ketogenic diet (VLC/KD) for at least 24 months, with evidence of significant elevations in LDL-C after commencing the diet.

Participants will be recruited online through social media including Facebook groups discussing VLC/KDs. The target population are those who experience significant increases in LDL-C on VLC/KDs whilst also being healthy and relatively lean (BMI <30mg/kg2 and waist circumference <102 cm and 88 cm for men and women respectively if BMI 25-30 mg/kg2).

Once participants present their interest to participate in the study by responding to the social media flyer and made an attempt to get in touch with the study site, study staff will reach out to the participant over the phone using an IRB (Institutional Review Board) approved screening questionnaire to verify eligibility and answer any question about the study. Once subject confirms that he/she is interested to participate, they will be informed that a copy of the Informed Consent Form (ICF) will be emailed to them using a HIPAA compliant DocuSign (application to sign a document electronically) portal. Subjects are required to review and electronically sign the ICF. Once an ICF has been signed, subject will be asked to upload the relevant medical records to the HIPAA compliant RedCap portal as documentary evidence to the lipid levels. Once the study team reviews the medical records/lab results and confirm the subject eligibility, the travel arrangements to the study site for the in-person baseline visit will be made.

Study participants will have total of 2 in-person study visits (Baseline - visit 1 and 12 month - visit 2) and will have a 6 month - phone visit in between.

During the baseline site visit, the participants will be asked to take a genetic test, blood draw, ECG and CCTA. Study staff will also be collecting vital signs, medical history, physical exam and questionnaire. Study participants will be asked to measure their morning blood ketone and glucose levels every day and report the results using KetoMojo application.

Subjects will be informed about the possible risk associated with the study participation including radiation from the CT scan/CCTA, risks associated with the taking Beta-blocker, Calcium channel blocker, Nitroglycerin as well as IV insertion.

Recruitment will take place over 6 months, with follow up over 12 months. The study design calls for the enrollment of 100 eligible subjects.

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Study Type : Observational
Actual Enrollment : 100 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Diet-induced Elevations in LDL-C and Progression of Atherosclerosis
Actual Study Start Date : October 18, 2021
Actual Primary Completion Date : February 12, 2024
Actual Study Completion Date : February 12, 2024

Resource links provided by the National Library of Medicine





Primary Outcome Measures :
  1. Percent change in total non-calcified coronary plaque volume [ Time Frame: 12 months ]
    Percent change in total non-calcified coronary plaque volume from baseline (start of the study) till the final visit will be measured using Coronary Computed Tomography Angiography (CCTA).



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Lean Mass Hyper-Responders: The target population are those who experience significant increases in LDL-C on VLC/KDs whilst also being healthy and relatively lean (BMI <30mg/kg2 and waist circumference <102 cm and 88 cm for men and women respectively if BMI 25-30 mg/kg2). These individuals are referred to as lean mass hyper-responders (LMHRs) with diet-induced hypercholesterolemia (DIH).
Criteria

Inclusion Criteria:

  • Age ≥ 18 years old
  • Had an LDL cholesterol of 160 mg/dL or below from most recent labs taken before adopting a low carb diet (requires documentary evidence)
  • Has seen an increase of LDL cholesterol to 190 mg/dL or above from most recent labs on current diet **
  • Has LDL cholesterol levels at least 50% or greater compared to most recent documented value prior to starting the diet.
  • On low carb, ketogenic diet for the last 24 months or more.
  • HDL-C ≥ 60 mg/dL and triglyceride level ≤ 80 mg/dL **
  • Willingness to participate in the study and ability to sign informed consent
  • In the investigator's opinion subjects are willing and likely able to comply with scheduled visits, laboratory tests, and other study procedures.
  • Normal to low BP (systolic ≤ 130 mm Hg or diastolic ≤ 80 mm Hg) at screening/baseline (visit 1).
  • Fasting glucose < 110 mg/dL and HbA1c < 6.0%) **
  • hsCRP < 2 mg/L **
  • No prior diagnosis of Type 2 Diabetes
  • No prior use of anti-diabetic medication
  • Not currently taking lipid lowering supplements or medications including statins, red yeast rice, garlic, ezetimibe, berberine

    • Requires documentary evidence

Exclusion Criteria:

  • Untreated hypothyroidism (TSH > 10)
  • Use of medications that elevated LDL-C (anabolic steroids, isotretinoin, immunosuppressants, amiodarone, thiazide diuretics, glucocorticoids, or thiazolidinediones)
  • Pregnancy
  • Has smoked more than 100 cigarettes in lifetime
  • An ongoing inflammatory disorder (e.g. psoriatic arthritis)
  • History of atherosclerotic heart disease
  • Known history of molecularly defined Familial Hypercholesterolemia
  • BMI = or > 30 kg/m^2 (or waist circumference > 88 cm or > 102 cm for women and men respectively if BMI between 25-30 kg/m^2)
  • Renal insufficiency (calculated creatinine clearance of <50 ml per minute, MDRD (modification of Diet in Renal Disease) equation).
  • Use of Lipid lowering medication (Statins, etc) at the time of most recent labs taken before starting Ketogenic diet.
  • AST (Aspartate aminotransferase) or ALT (Alanine Transaminase) >2 times the upper limit of normal (ULN) at the Screening visit (V1), or a total bilirubin >1.5 times the ULN unless the subject has a history of Gilbert's.
  • Subject unable to provide medical records indicating lab results before starting a keto- diet.
  • Subject has a history of malignancy ≤5 years prior to signing informed consent, except for adequately treated basal cell or squamous cell skin cancer or in situ cervical cancer.
  • Note (1) A subject with a history of malignancy >5 years prior to signing informed consent should have no evidence of residual or recurrent disease.
  • Other severe acute or chronic medical or psychiatric condition or laboratory abnormality at the Screening visit (V1) that may increase the risk associated with trial participation or investigational product administration or may interfere with the interpretation of trial results and, in the judgment of the investigator, would make the subject inappropriate for entry into this trial.
  • Subjects with known allergy to iodinated contrast material
  • Subject is pregnant or breast-feeding, or is expecting to conceive during the study period.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT05733325


Locations
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United States, California
Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center (The Lundquist Institute)
Torrance, California, United States, 90502
Sponsors and Collaborators
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Citizen Science Foundation
Investigators
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Principal Investigator: Matthew A Budoff, MD The Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center
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Responsible Party: Matthew J. Budoff, Professor of Medicine, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
ClinicalTrials.gov Identifier: NCT05733325    
Other Study ID Numbers: CSF-A1
First Posted: February 17, 2023    Key Record Dates
Last Update Posted: March 19, 2024
Last Verified: March 2024

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Atherosclerosis
Hypercholesterolemia
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases
Hyperlipidemias
Dyslipidemias
Lipid Metabolism Disorders
Metabolic Diseases