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Remote Neuropsychological Assessment of Patients With Neurological Disorders and Injuries

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT05819008
Recruitment Status : Recruiting
First Posted : April 19, 2023
Last Update Posted : May 9, 2024
Västerbotten County Council, Sweden
Information provided by (Responsible Party):
Nils Berginström, Umeå University

Brief Summary:

For the last decades, many aspects of human life have been altered by digital technology. For health care, this have opened a possibility for patients who have difficulties travelling a long distance to a hospital to meet with their health care providers over different digital platforms. With an increased digital literacy, and an aging population often living in the countryside, far from hospitals or other health care settings, an increasing need for digitalization of meetings between patients and health care personnel is inevitable.

However, neuropsychological assessment is one sort of health care not possible to directly transfer into digital form. These evaluations are most often performed with well validated tests, only to be used in a paper-pencil form with a specially trained psychologist during physical meetings.

The aim of this project is to investigate whether a newly developed digital neuropsychological test battery can be used to perform remote assessments of cognitive function in patients with neurological injuries and impairments. To this date, there are no such test batteries available in the Swedish language.

Mindmore ( is a test system developed in Sweden, performing neuropsychological tests on a tablet, but still with the psychologist present in the room. This system is now evolving into offering the possibility for the patient to perform the test in their own home, using their own computer or tablet. The aim of the present research project is to validate this latter system (Mindmore Distance), using the following research questions:

  1. Are the tests in Mindmore Distance equivalent to traditional neuropsychological tests in patients with traumatic brain injury, stroke, multiple sclerosis, Parkinson's Disease, epilepsy, and brain tumor?
  2. Can the results from Mindmore Distance be transferred into neuropsychological profiles that can be used in diagnostics for specific patient groups?
  3. How do the patients experience undergoing a neuropsychological evaluation on their own compared to traditional neuropsychological assessment in a physical meeting with a psychologist?

Condition or disease Intervention/treatment
Traumatic Brain Injury Stroke Multiple Sclerosis Parkinson Disease Epilepsy Brain Tumor Diagnostic Test: Neuropsychological Assessment

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Study Type : Observational
Estimated Enrollment : 350 participants
Observational Model: Case-Control
Time Perspective: Cross-Sectional
Official Title: Remote Neuropsychological Assessment of Patients With Neurological Disorders and Injuries
Actual Study Start Date : March 10, 2023
Estimated Primary Completion Date : December 31, 2025
Estimated Study Completion Date : December 31, 2025

Resource links provided by the National Library of Medicine

Group/Cohort Intervention/treatment
Patients with neurological disorders or injuries and Healthy Controls Diagnostic Test: Neuropsychological Assessment

To validate Mindmore Distance (MD), the following standard neuropsychological tests will be used in a testing session with a psychologist:

  • Wordlist 1 and 2 from WMS-III (Wechsler, 1997). Equivalent to RAVLT in MD
  • Coding from WAIS-IV (Wechsler, 2008). Equivalent to SDPT in MD
  • Block Span from WMS-III (Wechsler, 1997). Equivalent to CBT in MD
  • Trail Making Test from D-KEFS (Delis et al., 2001). Equivalent to TMT-Click in MD
  • Color-Word Interference Test from D-KEFS. Equivalent to Stroop in MD
  • Verbal fluency from D-KEFS. Equivalent to FAS in MD

All participants will complete some questionnaires: Hospital Anxiety and Depression Scale (Zigmond & Snaith, 1983); Insomnia Severity Index (Bastien, Vallieres, & Morin, 2001); Cognitive Failure Questionnaire (Broadbent, Cooper, FitzGerald, & Parkes, 1982); Perceived Stress Scale (Levenstein et al., 1993); Multidimensional Fatigue Inventory (Smets, Garssen, Bonke, & De Haes, 1995).

Primary Outcome Measures :
  1. Validity of Rey Auditory Verbal Learning Test in Mindmore [ Time Frame: Baseline ]
    The results of RAVLT in Mindmore will be validated against Word List Recall from Wechsler Memory Scale - Third edition.

  2. Validity of Symbol Digit Processing Test in Mindmore [ Time Frame: Baseline ]
    The results of SDPT in Mindmore will be validated against Coding from Wechsler Adult Intelligence Scale - Fourth edition.

  3. Validity of Corsi Block Test in Mindmore [ Time Frame: Baseline ]
    The results of CBT in Mindmore will be validated against Block Span from Wechsler Memory Scale - Third edition.

  4. Validity of Trail Making Test - Click in Mindmore [ Time Frame: Baseline ]
    The results of TMT-Click in Mindmore will be validated against Trail Making Test from Delis-Kaplan Executive Functions System.

  5. Validity of Stroop in Mindmore [ Time Frame: Baseline ]
    The results of Stroop in Mindmore will be validated against Color-Word Interference Test from Delis-Kaplan Executive Functions System.

  6. Validity of FAS in Mindmore [ Time Frame: Baseline ]
    The results of FAS in Mindmore will be validated against Verbal Fluency from Delis-Kaplan Executive Functions System.

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Outpatients treated at the Neuro-Head-Neck-Center (NHHC) at Umeå University hospital. When referred to neuropsychological examination at NHHC, patients will receive written information about the project and contact information to the principal investigator to whom they can turn for questions, before signing informed consent.

Patient groups included are:

  • Traumatic brain injury (TBI), including patients with persisting symptoms after concussion, post-concussional disorder.
  • Stroke
  • Multiple sclerosis
  • Parkinson's Disease
  • Epilepsy
  • Brain Tumors

A comparison group of healthy volunteers will be recruited using advertising.


Inclusion Criteria:

  • age 18 and above
  • Diagnosed with a neurological disorder or injury, alternatively under medical examination for such a diagnosis
  • Owns and can handle a computer with internet connection

Exclusion Criteria:

  • Severe psychiatric disorder, such a schizophrenia, severe depression
  • Addiction of alcohol or other substances
  • Not speaker of Swedish
  • On sedatives, such as sleep or pain medication
  • Multiple neurological diagnoses
  • Not being able to participate in a neuropsychological examination, or to give informed consent

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT05819008

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Contact: Nils Berginström, PhD +46(0)90-786 88 64

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Umeå University Hospital Recruiting
Umeå, Sweden, 90185
Contact: Nils Berginström, PhD    0730300303   
Sponsors and Collaborators
Umeå University
Västerbotten County Council, Sweden
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Principal Investigator: Nils Berginström, PhD Umeå Universitet, Department of Psychology
Daniel MH, Wahlstrom D, Zhang O. Equivalence of Q-interactive® and Paper Administrations of Cognitive Tasks: WISC®-V. NCS Pearson Inc.; 2014.
Delis DC, Kaplan E, Kramer JH. D-KEFS - Delis Kaplan Executive Functions System - Technical Manual. San Antonio: Pearson; 2001.
Dikmen SS, Machamer JE, Winn HR, Temkin NR. Neuropsychological Outcome at 1-Year Post Head-Injury. Neuropsychology. 1995;9(1):80-90.
Lezak MD, Howieson DB, Loring DW. Neuropsychological Assessment. 4 ed. New York: Oxford University Press; 2004.
Wechsler D. Wechsler Adult Intelligence Scale-Fourth Edition. San Antonio: Pearson; 2008.
Mitrushina MN, Boone KB, D'Elia LF. Handbook of Normative Data for Neuropsychological Assessment. New York: Oxford University Press; 1999.
Wechsler D. Wechsler Memory Scale - Third Edition. San Antonio: Psychological Corporation; 1997.

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Responsible Party: Nils Berginström, Associate Professor, Umeå University Identifier: NCT05819008    
Other Study ID Numbers: 7004076
First Posted: April 19, 2023    Key Record Dates
Last Update Posted: May 9, 2024
Last Verified: May 2024
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Nils Berginström, Umeå University:
Neuropsychological assessment
Additional relevant MeSH terms:
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Parkinson Disease
Multiple Sclerosis
Brain Injuries
Brain Injuries, Traumatic
Nervous System Diseases
Wounds and Injuries
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Movement Disorders
Neurodegenerative Diseases
Demyelinating Autoimmune Diseases, CNS
Autoimmune Diseases of the Nervous System
Demyelinating Diseases
Autoimmune Diseases
Immune System Diseases
Craniocerebral Trauma
Trauma, Nervous System