A Dose Finding Phase 1 of Sarilumab Plus Capecitabine in HER2/Neu-Negative Metastatic Breast Cancer and a Single-arm, Historically-controlled Phase 2 Study of Sarilumab Plus Capecitabine in Stage I-III Triple Negative Breast Cancer With High-Risk Residual Disease (EMPOWER) (EMPOWER)

• ClinicalTrials.gov Identifier: NCT04333706
• Recruitment Status: Recruiting
• First Posted: April 3, 2020
• Last Update Posted: January 18, 2024
• Sponsor: University of Southern California
• Collaborator: National Cancer Institute (NCI)
• Information provided by (Responsible Party): University of Southern California

Tracking Information

• First Submitted Date: April 1, 2020
• First Posted Date: April 3, 2020
• Last Update Posted Date: January 18, 2024
• Actual Study Start Date: September 26, 2020
• Estimated Primary Completion Date: November 3, 2025 (Final data collection date for primary outcome measure)

Current Primary Outcome Measures (submitted: July 21, 2022)

• Phase I: Maximum Tolerated Dose (MTD) [ Time Frame: first treatment up to 9 weeks ]
  Establish MTD of sarilumab plus capecitabine in patients with metastatic TNBC and metastatic HER2/neu-negative and hormone resistant breast cancer
• Phase I: Dose-limiting toxicity (DLT) [ Time Frame: first treatment up to 9 weeks ]
  Defined events that are possibly, probably, or definitely related to the study treatment:
• Phase II:To determine the percent of patients with positive CTCs and DTCs (if available) becoming negative CTCs and DTCs (if available) after treatment [ Time Frame: baseline up to 14 weeks ]
  Bone marrow aspirates will be performed before treatment and at defined time points during treatment.

Original Primary Outcome Measures (submitted: April 1, 2020)

• Phase I: Maximum Tolerated Dose (MTD) [ Time Frame: first treatment up to 9 weeks ]
  Establish MTD of sarilumab plus capecitabine in patients with metastatic TNBC and metastatic HER2/neu-negative and hormone resistant breast cancer
• Phase I: Dose-limiting toxicity (DLT) [ Time Frame: first treatment up to 9 weeks ]
  Defined events that are possibly, probably, or definitely related to the study treatment:
• Phase II:To determine the percent of patients with positive DTC becoming negative DTCs after treatment [ Time Frame: baseline up to 14 weeks ]
  Bone marrow aspirates will be performed before treatment and at defined time points during treatment.

• Current Secondary Outcome Measures: Not Provided
• Original Secondary Outcome Measures: Not Provided
• Current Other Pre-specified Outcome Measures: Not Provided
• Original Other Pre-specified Outcome Measures: Not Provided

Descriptive Information

• Brief Title: A Dose Finding Phase 1 of Sarilumab Plus Capecitabine in HER2/Neu-Negative Metastatic Breast Cancer and a Single-arm, Historically-controlled Phase 2 Study of Sarilumab Plus Capecitabine in Stage I-III Triple Negative Breast Cancer With High-Risk Residual Disease (EMPOWER)
• Official Title: A Dose Finding Phase 1 of Sarilumab Plus Capecitabine in HER2/Neu-Negative Metastatic Breast Cancer and a Single-arm, Historically-controlled Phase 2 Study of Sarilumab Plus Capecitabine in Stage I-III Triple Negative Breast Cancer With High-Risk Residual Disease (EMPOWER)
• Brief Summary: This study looks to advance a novel and potent strategy to eliminate minimal residual disease (MRD) in triple negative breast cancer (TNBC) present even after multimodal treatment, thereby improving survival and increasing cure rate in this aggressive cancer. Patients with locally advanced TNBC are at high risk of developing lethal metastatic disease within 2 years of diagnosis, especially for those without a pathologic complete response (pCR) after neoadjuvant chemotherapy. The high risk occurs despite surgical excision of the primary tumor and axillary lymph nodes to eliminate residual disease.

Detailed Description

The study will consist of two phases, I and II.

Phase I will include patients with metastatic TNBC, HER2/neu-negative and hormone resistant breast cancer. A total of 4 doses of sarilumab will be given with the starting dose of 150 mg SQ at 3-weeks cycles given 3 days prior to each of the first 4 of 8 cycles of capecitabine (1000 mg/m2/BID; for 14 days every 21 days). If dose escalation is possible, sarilumab will be administered every 3 weeks at 200 mg SQ for 4 doses. Blood samples will be obtained prior during the course of treatment. Bone marrow samples are optional.

Phase II is a single arm study in Stage I to III TNBC with less than a complete pCR after neoadjuvant therapy evaluating the combination of sarilumab with capecitabine (1000mg/m2/BID; for 14 days every 21 days) as compared to historical control patients treated with capecitabine alone. There are 8 cycles of capecitabine. The first 4 cycles will be combined with sarilumab. The Phase II sarilumab dose will be determined by the Phase I best tolerated dose. Blood samples will be obtained prior during the course of treatment. Bone marrow samples are optional.

A pilot parallel biological baseline study of standard adjuvant capecitabine in stage I to III TNBC with less than a pCR will be performed. This Arm will be open in parallel with both Phases 1 and 2. Blood samples will be obtained prior during the course of treatment. Bone marrow samples are optional.

• Study Type: Interventional
• Study Phase: Phase 1; Phase 2
• Study Design: Allocation: Non-Randomized; Intervention Model: Parallel Assignment; Masking: None (Open Label); Primary Purpose: Treatment

Condition

• Breast
• Metastatic
• Triple Negative
• Cancer
• Disseminated Tumor Cell

Intervention

• Drug: Capecitabine
  Capecitabine 1000 mg BID
• Combination Product: Sarilumab 150mg or 200 mg plus Capecitabine
  Sarilumab 150mg or 200 mg plus Capecitabine 1000 mg BID
• Combination Product: Sarilumab 150mg plus Capecitabine
  Dose escalation schedule of sarilumab. The starting dose for sarilumab is 150 mg SQ every 21 days, given 3 days prior to the first 4 of 8 cycles of capecitabine 1000 mg BID.

Study Arms

• Experimental: Experimental: Phase I
  A dose finding study of sarilumab plus capecitabine in patients with metastatic TNBC and metastatic HER2/neu-negative and hormone resistant breast cancer.
  Interventions:

  • Combination Product: Sarilumab 150mg or 200 mg plus Capecitabine
  • Combination Product: Sarilumab 150mg plus Capecitabine
• Experimental: Phase 2 single arm study
  Study of adjuvant sarilumab plus capecitabine in stage I to III TNBC with less than a pCR
  Interventions:

  • Combination Product: Sarilumab 150mg or 200 mg plus Capecitabine
  • Combination Product: Sarilumab 150mg plus Capecitabine
• Parallel Baseline Arm
  Study of standard adjuvant capecitabine in stage I to III TNBC with less than a pCR. This Arm will be open in parallel with both Phases 1 and 2. Blood samples will be obtained during the course of the study. Bone marrow samples are optional.
  Intervention: Drug: Capecitabine

• Publications *: Not Provided

Recruitment Information

• Recruitment Status: Recruiting
• Estimated Enrollment (submitted: July 12, 2021): 65
• Original Estimated Enrollment (submitted: April 1, 2020): 50
• Estimated Study Completion Date: November 3, 2026
• Estimated Primary Completion Date: November 3, 2025 (Final data collection date for primary outcome measure)

Eligibility Criteria

Inclusion Criteria:

• A. Written informed consent obtained from the subject and the ability for the subject to comply with all the study-related procedures.
• B. Both males and females ≥ eighteen years of age
• C. A clinical diagnosis of metastatic triple negative or hormone resistant, Her2/neu-negative breast cancer that has been confirmed histologically at one point during the course of the disease. TNBC is defined as ER/PR IHC positivity rate of <10% and Her2Neu-negative (Phase I only)
• D. A life expectancy of at least 6 months. (Phase I only)
• E. Any previous cytotoxic chemotherapy must have been a minimum of 3 weeks prior to study drug administration. There is no limit on the number of prior therapies. For ER/PR-positive tumors, endocrine therapy must have been included in at least one of those prior regimens. Prior capecitabine is allowed only if not given in the treatment regimen immediately prior to the enrollment in this study. (Phase I only)
• F. A diagnosis of TNBC confirmed histologically and defined as ER/PR IHC positivity rate of <10% and Her2/neu-negative. (Phase II and Parallel Baseline Arm only)
• G. A pathologic confirmation of stage I, or II, or III breast cancer with less than a complete pCR, defined as the absence of residual invasive cancer in resected breast specimen and sampled lymph nodes with residual noninvasive cancer or in situ disease allowed. (Phase II and Parallel Baseline Arm only)
• H. Must not have received prior systemic treatment for breast cancer except for those included in the neoadjuvant regimen and the neoadjuvant regimen must not have included capecitabine nor sarilumab. (Phase II and Parallel Baseline Arm only)
• I. An ECOG Performance Status ≤2.

• J. Adequate organ function defined as:

  1. Absolute neutrophil count (ANC) > 1500/mcl (use of G-CSF is allowed)
  2. Platelets ≥ 100,000/mcl
  3. Hemoglobin ≥ 9 (pRBC +/- ESA are allowed)
  4. ALT ≤ 5 x ULN
  5. AST ≤ 5 x ULN
  6. Bilirubin ≤ 3 x ULN
  7. GFR ≥ 30 ml/min
• K. Women of childbearing potential (WOCBP) must be using a highly effective method of contraception to avoid pregnancy throughout the study and for at least 24 weeks after the last dose of study drug to minimize the risk of pregnancy. Prior to study enrollment, women of childbearing potential must be advised of the importance of avoiding pregnancy during trial participation and the potential risk factors for an unintentional pregnancy.
• L. Males with female partners of child-bearing potential must agree to use physician-approved contraceptive methods (e.g., abstinence, condoms, vasectomy) throughout the study and should avoid conceiving children for 24 weeks following the last dose of study drug.

Exclusion Criteria:

• A. Females or males of childbearing potential who are unwilling or unable to use an acceptable method to avoid pregnancy for the entire study period and for at least 24 weeks after the last dose of study drug.
• B. Females who are pregnant or breastfeeding.
• C. History of any other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of protocol therapy or that might affect the interpretation of the results of the study or that puts the subject at high risk for treatment complications, in the opinion of the treating physician.
• D. Hepatitis B infection except for prior vaccination. (Phase I and Phase II only).
• E. Known history of tuberculosis injection. (Phase I and Phase II only).
• F. A history of diverticulitis. (Phase I and Phase II only).
• G. Use of live vaccines within 30 days prior to study treatment due to the risk of infection. Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella (MMR), varicella/zoster (chicken pox), yellow fever, rabies, Bacillus Calmette-Guérin (BCG), and typhoid vaccine. Seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g. FluMist) are live attenuated vaccines and are not allowed. (Phase I and Phase II only)
• H. History of other malignancy that in the primary oncologist's estimation has at the time of study participation a higher risk of recurrence or death than the study-related cancer.
• I. Prisoners or subjects who are involuntarily incarcerated.
• J. Subjects who are compulsorily detained for treatment of either a psychiatric or physical illness.
• K. Subjects demonstrating an inability to comply with the study and/or follow-up procedures.

Sex/Gender

• Sexes Eligible for Study: All

• Ages: 18 Years to 99 Years (Adult, Older Adult)
• Accepts Healthy Volunteers: No

Contacts

Contact: Kimberly Arieli, RN; 323-865-3935; Kimberly.Arieli@med.usc.edu

• Listed Location Countries: United States

Administrative Information

• NCT Number: NCT04333706
• Other Study ID Numbers: 1B-22-3; HS-23-00019 ( Other Identifier: USC IRB ); 1R01CA238387-01A1 ( U.S. NIH Grant/Contract )
• Has Data Monitoring Committee: Yes

U.S. FDA-regulated Product

• Studies a U.S. FDA-regulated Drug Product: Yes
• Studies a U.S. FDA-regulated Device Product: No

IPD Sharing Statement

• Plan to Share IPD: No

• Current Responsible Party: University of Southern California
• Original Responsible Party: University of Florida
• Current Study Sponsor: University of Southern California
• Original Study Sponsor: University of Florida
• Collaborators: National Cancer Institute (NCI)

Investigators

• Principal Investigator: Priya Jayachandran, MD; University of Southern California

• PRS Account: University of Southern California
• Verification Date: January 2024