A Study of GlcNAc on Tear Production in NGLY1-CDDG
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ClinicalTrials.gov Identifier: NCT05402345 |
Recruitment Status :
Not yet recruiting
First Posted : June 2, 2022
Last Update Posted : April 1, 2024
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Sponsor:
Eva Morava-Kozicz
Collaborators:
Children's Hospital of Philadelphia
Seattle Children's Hospital
Information provided by (Responsible Party):
Eva Morava-Kozicz, Icahn School of Medicine at Mount Sinai
Tracking Information | |||||
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First Submitted Date ICMJE | May 28, 2022 | ||||
First Posted Date ICMJE | June 2, 2022 | ||||
Last Update Posted Date | April 1, 2024 | ||||
Estimated Study Start Date ICMJE | May 2024 | ||||
Estimated Primary Completion Date | June 2025 (Final data collection date for primary outcome measure) | ||||
Current Primary Outcome Measures ICMJE |
Difference in tear production from baseline in placebo vs GlcNAc group [ Time Frame: 6 weeks ] The primary endpoint of the study is the difference in tear production from baseline in individuals with NGLY1-CDDG between the placebo and the GlcNAc group after 6 weeks of blinded therapy, as measured by Schirmer II test which is a tool that helps assess the amount of tears in the eyes.
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Original Primary Outcome Measures ICMJE |
Difference in mL in tear production in placebo vs GlcNAc group [ Time Frame: 8 weeks ] The primary endpoint of the study is the difference in tear production in individuals with NGLY1-CDDG between the placebo and the GlcNAc group after 4-8 weeks of blinded therapy, as measured by Schirmer test.
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Change History | |||||
Current Secondary Outcome Measures ICMJE |
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Original Secondary Outcome Measures ICMJE | Not Provided | ||||
Current Other Pre-specified Outcome Measures | Not Provided | ||||
Original Other Pre-specified Outcome Measures | Not Provided | ||||
Descriptive Information | |||||
Brief Title ICMJE | A Study of GlcNAc on Tear Production in NGLY1-CDDG | ||||
Official Title ICMJE | A Phase II Randomized, Multicenter, Double-Blind, Placebo-Controlled Study Evaluating Effect Of GlcNAc On Tear Production In Individuals With NGLY1-CDDG | ||||
Brief Summary | In patients with NGLY1-CDDG, the disorder can lead to eye damage due to not being able to produce enough tears. This study is being done to see if the dietary supplement, GlcNAc, improves tear production in patients with NGLY1-CDDG. | ||||
Detailed Description | This study is a multicenter randomized, double-blind, placebo-controlled trial of GlcNAc supplementation for improvement of tear production in NGLY1-CDDG. Clinical history and screening data will be reviewed to determine subject eligibility. If a subject is already on GlcNAc, a washout period of 1 month will be required prior to consent and randomization. Interested subjects who have a molecularly confirmed diagnosis of NGLY1-CDDG will be consented. Baseline data will be collected prior to randomization at treatment initiation. Subjects will then be randomized to placebo or GlcNAc. They will be administered weight-dependent doses of GlcNAc or an equivalent volume of placebo enterally for 6 weeks, followed by open label weight-dependent doses of GlcNAc for 6 weeks. A visit for evaluation and collection of lab samples will be conducted at 6 and 12 weeks. | ||||
Study Type ICMJE | Interventional | ||||
Study Phase ICMJE | Phase 2 | ||||
Study Design ICMJE | Allocation: Randomized Intervention Model: Parallel Assignment Masking: Triple (Participant, Care Provider, Investigator) Primary Purpose: Treatment |
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Condition ICMJE | NGLY1 Deficiency | ||||
Intervention ICMJE |
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Study Arms ICMJE |
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Publications * | Not Provided | ||||
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline. |
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Recruitment Information | |||||
Recruitment Status ICMJE | Not yet recruiting | ||||
Estimated Enrollment ICMJE |
18 | ||||
Original Estimated Enrollment ICMJE |
16 | ||||
Estimated Study Completion Date ICMJE | June 2025 | ||||
Estimated Primary Completion Date | June 2025 (Final data collection date for primary outcome measure) | ||||
Eligibility Criteria ICMJE | Inclusion Criteria:
Exclusion Criteria
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Sex/Gender ICMJE |
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Ages ICMJE | 1 Year to 60 Years (Child, Adult) | ||||
Accepts Healthy Volunteers ICMJE | No | ||||
Contacts ICMJE |
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Listed Location Countries ICMJE | United States | ||||
Removed Location Countries | |||||
Administrative Information | |||||
NCT Number ICMJE | NCT05402345 | ||||
Other Study ID Numbers ICMJE | 23-020868 8404 ( Other Identifier: FCDGC ) |
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Has Data Monitoring Committee | No | ||||
U.S. FDA-regulated Product |
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IPD Sharing Statement ICMJE |
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Current Responsible Party | Eva Morava-Kozicz, Icahn School of Medicine at Mount Sinai | ||||
Original Responsible Party | Eva Morava-Kozicz, Mayo Clinic, MD, PhD | ||||
Current Study Sponsor ICMJE | Eva Morava-Kozicz | ||||
Original Study Sponsor ICMJE | Same as current | ||||
Collaborators ICMJE |
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Investigators ICMJE |
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PRS Account | Icahn School of Medicine at Mount Sinai | ||||
Verification Date | March 2024 | ||||
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP |