The classic website will no longer be available as of June 25, 2024. Please use the modernized ClinicalTrials.gov.
Working…
ClinicalTrials.gov
ClinicalTrials.gov Menu

Longevity Families of the Netherlands (LOF-NL)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT06374069
Recruitment Status : Recruiting
First Posted : April 18, 2024
Last Update Posted : April 18, 2024
Sponsor:
Collaborators:
Jacobijn Gussekloo, Prof. dr.
Simon P. Mooijaart, Prof. dr.
Information provided by (Responsible Party):
Eline Slagboom, Leiden University Medical Center

Tracking Information
First Submitted Date March 20, 2024
First Posted Date April 18, 2024
Last Update Posted Date April 18, 2024
Actual Study Start Date September 11, 2023
Estimated Primary Completion Date December 2026   (Final data collection date for primary outcome measure)
Current Primary Outcome Measures
 (submitted: April 15, 2024)		 Identifying the genetic variants of Familial Longevity [ Time Frame: through study completion, an average of 2 years ]
To identify gene variants associated with healthy aging and protection from (multi)morbidity
Original Primary Outcome Measures Same as current
Change History No Changes Posted
Current Secondary Outcome Measures
 (submitted: April 15, 2024)		 Studying the environmental factor of Familial Longevity through questionnaires and its interaction with the genetic component [ Time Frame: through study completion, an average of 2 years ]
To study the social-, environment- and behavioral factors of familial longevity, their role in (multi-)morbidity and its interaction with the genetic component
Original Secondary Outcome Measures Same as current
Current Other Pre-specified Outcome Measures Not Provided
Original Other Pre-specified Outcome Measures Not Provided
 
Descriptive Information
Brief Title Longevity Families of the Netherlands
Official Title Longevity Families of the Netherlands
Brief Summary

The demographic life expectancy enhancement of the past 150 years imposes an urgent challenge in Western and economically growing societies to stimulate the healthy lifespan that is lagging behind. Families surviving into exceptionally high ages (longevity) in good physical and mental health illustrate that this is physiologically possible. Such families harbor cross generational socio-genetic mechanisms that mediate healthy aging and protection from (multi)morbidity.

The purpose of our research is: to identify gene variants associated with healthy aging and protection from (multi)morbidity; to study the social-, environment- and behavioral factors of familial longevity, their role in (multi-)morbidity and its interaction with the genetic component.
Detailed Description Not Provided
Study Type Observational
Study Design Observational Model: Family-Based
Time Perspective: Cross-Sectional
Target Follow-Up Duration Not Provided
Biospecimen Not Provided
Sampling Method Non-Probability Sample
Study Population

Dutch Caucasian descent:

Ages 75 and older, with siblings enriched for familial longevity, and individuals without a history of familial longevity
Condition
  • Longevity
  • Familial Longevity
  • Extreme Longevity
  • Aging
Intervention Not Provided
Study Groups/Cohorts
  • Cases - Enriched for familial longevity
    Siblings of dutch Caucasian descent ages 75 and older
  • Controls - Non-enriched for familial longevity
    Individuals of dutch Caucasian descent ages 75 and older solely in their family.
Publications * Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status Recruiting
Estimated Enrollment
 (submitted: April 15, 2024)		 600
Original Estimated Enrollment Same as current
Estimated Study Completion Date December 2026
Estimated Primary Completion Date December 2026   (Final data collection date for primary outcome measure)
Eligibility Criteria

Inclusion Criteria:

  • Siblings of Dutch Caucasian descent age 75+ enriched for familial longevity
  • Individuals of Dutch Caucasian descent age 75+ who are not enriched for familial longevity

Exclusion Criteria:

-
Sex/Gender
Sexes Eligible for Study: All
Ages 75 Years and older   (Older Adult)
Accepts Healthy Volunteers Yes
Contacts
Contact: (Eline) P. Slagboom, Prof. dr. +31(0)71 5269 730 p.slagboom@lumc.nl
Listed Location Countries Netherlands
Removed Location Countries  
 
Administrative Information
NCT Number NCT06374069
Other Study ID Numbers NL81887.058.23
Has Data Monitoring Committee Not Provided
U.S. FDA-regulated Product
Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
IPD Sharing Statement Not Provided
Current Responsible Party Eline Slagboom, Leiden University Medical Center
Original Responsible Party Same as current
Current Study Sponsor Leiden University Medical Center
Original Study Sponsor Same as current
Collaborators
  • Jacobijn Gussekloo, Prof. dr.
  • Simon P. Mooijaart, Prof. dr.
Investigators Not Provided
PRS Account Leiden University Medical Center
Verification Date April 2024