Time Frame |
From the first dose administration up to approximately up to 59.5 months for Phase 1 Dose escalation; up to 50.5 months for Phase 1 Dose expansion Cohorts and up to 37.5 months for Phase 2
|
Adverse Event Reporting Description |
Safety Population (all treated participants) included all participants who had received at least 1 dose of TAS-120. MedDRA version 17.0 for Phase 1 and MedDRA version 22.0 for Phase 2. Safety analysis were done based on data cut-off dates: 12 July 2019 for Phase 1 Dose Escalation, 29-May-2021 for Phase 1 Dose Expansion and Phase 2.
|
|
Arm/Group Title
|
Phase 1: Dose Escalation: QOD Dosing: 8 mg
|
Phase 1: Dose Escalation: QOD Dosing: 16 mg
|
Phase 1: Dose Escalation: QOD Dosing: 24 mg
|
Phase 1: Dose Escalation: QOD Dosing: 36 mg
|
Phase 1: Dose Escalation: QOD Dosing: 56 mg
|
Phase 1: Dose Escalation: QOD Dosing: 80 mg
|
Phase 1: Dose Escalation: QOD Dosing: 120 mg
|
Phase 1: Dose Escalation: QOD Dosing: 160 mg
|
Phase 1: Dose Escalation: QOD Dosing: 200 mg
|
Phase 1: Dose Escalation: QD Dosing: 4 mg
|
Phase 1: Dose Escalation: QD Dosing: 8 mg
|
Phase 1: Dose Escalation: QD Dosing: 16 mg
|
Phase 1: Dose Escalation: QD Dosing: 20 mg
|
Phase 1: Dose Escalation: QD Dosing: 24 mg
|
Phase 1: Dose Expansion Cohort 1
|
Phase 1: Dose Expansion: Cohort 2
|
Phase 1: Dose Expansion: Cohort 3
|
Phase 1: Dose Expansion: Cohort 4
|
Phase 1: Dose Expansion: Cohort 5
|
Phase 1: Dose Expansion: Cohort 6
|
Phase 1: Dose Expansion: Sub-cohort 2
|
Phase 1: Dose Expansion: Sub-cohort 1
|
Phase 2
|
Arm/Group Description |
Participants with or without FGF/FG...
|
Participants with or without FGF/FG...
|
Participants with or without FGF/FG...
|
Participants with or without FGF/FG...
|
Participants with FGF/FGFR gene abn...
|
Participants with FGF/FGFR gene abn...
|
Participants with FGF/FGFR gene abn...
|
Participants with FGF/FGFR gene abn...
|
Participants with FGF/FGFR gene abn...
|
Participants with or without FGF/FG...
|
Participants with or without FGF/FG...
|
Participants with or without FGF/FG...
|
Participants with or without FGF/FG...
|
Participants with or without FGF/FG...
|
Participants with intra-hepatic or ...
|
Participants with primary central n...
|
Participants with advanced urotheli...
|
Participants with breast or gastric...
|
Participants with tumor types harbo...
|
Participants who were not included ...
|
Participants with other tumor types...
|
Participants with iCCA who were enr...
|
Participants with iCCA with tumors ...
|
Arm/Group Description |
Participants with or without FGF/FGFR gene abnormalities received orally TAS-120 8 mg orally QOD (Monday, Wednesday and Friday of each week) in a 21-day treatment cycle until disease progression, unacceptable toxicity, withdrawal of consent or death.
|
Participants with or without FGF/FGFR gene abnormalities received orally TAS-120 16 mg orally QOD (Monday, Wednesday and Friday of each week) in a 21-day treatment cycle until disease progression, unacceptable toxicity, withdrawal of consent or death.
|
Participants with or without FGF/FGFR gene abnormalities received orally TAS-120 24 mg orally QOD (Monday, Wednesday and Friday of each week) in a 21-day treatment cycle until disease progression, unacceptable toxicity, withdrawal of consent or death.
|
Participants with or without FGF/FGFR gene abnormalities received orally TAS-120 36 mg orally QOD (Monday, Wednesday and Friday of each week) in a 21-day treatment cycle until disease progression, unacceptable toxicity, withdrawal of consent or death.
|
Participants with FGF/FGFR gene abnormalities received orally TAS-120 56 mg orally QOD (Monday, Wednesday and Friday of each week) in a 21-day treatment cycle until disease progression, unacceptable toxicity, withdrawal of consent or death.
|
Participants with FGF/FGFR gene abnormalities received orally TAS-120 80 mg orally QOD (Monday, Wednesday and Friday of each week) in a 21-day treatment cycle until disease progression, unacceptable toxicity, withdrawal of consent or death.
|
Participants with FGF/FGFR gene abnormalities received orally TAS-120 120 mg orally QOD (Monday, Wednesday and Friday of each week) in a 21-day treatment cycle until disease progression, unacceptable toxicity, withdrawal of consent or death.
|
Participants with FGF/FGFR gene abnormalities received orally TAS-120 160 mg orally QOD (Monday, Wednesday and Friday of each week) in a 21-day treatment cycle until disease progression, unacceptable toxicity, withdrawal of consent or death.
|
Participants with FGF/FGFR gene abnormalities received orally TAS-120 200 mg orally QOD (Monday, Wednesday and Friday of each week) in a 21-day treatment cycle until disease progression, unacceptable toxicity, withdrawal of consent or death.
|
Participants with or without FGF/FGFR gene abnormalities received a dose between 4 mg orally once daily (QD) in a 21-day treatment cycle until disease progression, unacceptable toxicity, withdrawal of consent or death.
|
Participants with or without FGF/FGFR gene abnormalities received a dose between 8 mg orally QD in a 21-day treatment cycle until disease progression, unacceptable toxicity, withdrawal of consent or death.
|
Participants with or without FGF/FGFR gene abnormalities received a dose between 16 mg orally QD in a 21-day treatment cycle until disease progression, unacceptable toxicity, withdrawal of consent or death.
|
Participants with or without FGF/FGFR gene abnormalities received a dose between 20 mg orally QD in a 21-day treatment cycle until disease progression, unacceptable toxicity, withdrawal of consent or death.
|
Participants with or without FGF/FGFR gene abnormalities received a dose between 24 mg orally QD in a 21-day treatment cycle until disease progression, unacceptable toxicity, withdrawal of consent or death.
|
Participants with intra-hepatic or extrahepatic cholangiocarcinoma (iCCA or eCCA) harboring FGFR2 gene fusions or rearrangements and who were treated or not treated with prior FGFR inhibitors received TAS-120 20 mg tablets orally QD in each of 21-day treatment cycle until disease progression, unacceptable toxicity, withdrawal of consent or death (maximum exposure: 33.5 months).
|
Participants with primary central nervous system (CNS) tumors harboring FGFR gene fusions or FGFR1 activating mutations received TAS-120 20 mg tablets orally QD in each of 21-day treatment cycle until disease progression, unacceptable toxicity, withdrawal of consent or death (maximum exposure: 28.5 months).
|
Participants with advanced urothelial carcinoma harboring FGFR3 gene fusions or FGFR3 activating mutations received TAS-120 20 mg tablets orally QD in each of 21-day treatment cycle until disease progression, unacceptable toxicity, withdrawal of consent or death (maximum exposure: 9.6 months).
|
Participants with breast or gastric cancer with harboring FGFR2 amplification received TAS-120 20 mg tablets orally QD in each of 21- day treatment cycle until disease progression, unacceptable toxicity, withdrawal of consent or death (maximum exposure: 5.5 months).
|
Participants with tumor types harboring FGFR gene fusions or activating mutations received TAS-120 20 mg tablets orally QD in each of 21- day treatment cycle until disease progression, unacceptable toxicity, withdrawal of consent or death (maximum exposure: 42.5 months).
|
Participants who were not included in Cohorts 1 to 5 received TAS-120 20 mg tablets orally QD in each of 21-day treatment cycle until disease progression, unacceptable toxicity, withdrawal of consent or death (maximum exposure: 11 months).
|
Participants with other tumor types who were enrolled prior to the confirmation of the RP2D received TAS-120 16 mg tablets orally QD in each of 21-day treatment cycle until disease progression, unacceptable toxicity, withdrawal of consent or death (maximum exposure: 45.5 months).
|
Participants with iCCA who were enrolled prior to the confirmation of the RP2D received TAS-120 16 mg tablets orally QD in each of 21-day treatment cycle until disease progression, unacceptable toxicity, withdrawal of consent or death (maximum exposure: 28 months).
|
Participants with iCCA with tumors harboring FGFR2 gene rearrangements received TAS-120 20 mg tablets orally QD in each of 21-day treatment cycle until disease progression, unacceptable toxicity, withdrawal of consent or death (maximum duration: 30 months).
|
|
|
Phase 1: Dose Escalation: QOD Dosing: 8 mg
|
Phase 1: Dose Escalation: QOD Dosing: 16 mg
|
Phase 1: Dose Escalation: QOD Dosing: 24 mg
|
Phase 1: Dose Escalation: QOD Dosing: 36 mg
|
Phase 1: Dose Escalation: QOD Dosing: 56 mg
|
Phase 1: Dose Escalation: QOD Dosing: 80 mg
|
Phase 1: Dose Escalation: QOD Dosing: 120 mg
|
Phase 1: Dose Escalation: QOD Dosing: 160 mg
|
Phase 1: Dose Escalation: QOD Dosing: 200 mg
|
Phase 1: Dose Escalation: QD Dosing: 4 mg
|
Phase 1: Dose Escalation: QD Dosing: 8 mg
|
Phase 1: Dose Escalation: QD Dosing: 16 mg
|
Phase 1: Dose Escalation: QD Dosing: 20 mg
|
Phase 1: Dose Escalation: QD Dosing: 24 mg
|
Phase 1: Dose Expansion Cohort 1
|
Phase 1: Dose Expansion: Cohort 2
|
Phase 1: Dose Expansion: Cohort 3
|
Phase 1: Dose Expansion: Cohort 4
|
Phase 1: Dose Expansion: Cohort 5
|
Phase 1: Dose Expansion: Cohort 6
|
Phase 1: Dose Expansion: Sub-cohort 2
|
Phase 1: Dose Expansion: Sub-cohort 1
|
Phase 2
|
|
Affected / at Risk (%) |
|
Affected / at Risk (%) |
|
Affected / at Risk (%) |
|
Affected / at Risk (%) |
|
Affected / at Risk (%) |
|
Affected / at Risk (%) |
|
Affected / at Risk (%) |
|
Affected / at Risk (%) |
|
Affected / at Risk (%) |
|
Affected / at Risk (%) |
|
Affected / at Risk (%) |
|
Affected / at Risk (%) |
|
Affected / at Risk (%) |
|
Affected / at Risk (%) |
|
Affected / at Risk (%) |
|
Affected / at Risk (%) |
|
Affected / at Risk (%) |
|
Affected / at Risk (%) |
|
Affected / at Risk (%) |
|
Affected / at Risk (%) |
|
Affected / at Risk (%) |
|
Affected / at Risk (%) |
|
Affected / at Risk (%) |
|
Total |
0/6 (0.00%)
|
|
0/3 (0.00%)
|
|
0/3 (0.00%)
|
|
0/3 (0.00%)
|
|
0/3 (0.00%)
|
|
0/5 (0.00%)
|
|
1/4 (25.00%)
|
|
0/8 (0.00%)
|
|
2/7 (28.57%)
|
|
0/4 (0.00%)
|
|
0/5 (0.00%)
|
|
2/14 (14.29%)
|
|
1/7 (14.29%)
|
|
1/14 (7.14%)
|
|
40/57 (70.18%)
|
|
22/34 (64.71%)
|
|
12/15 (80.00%)
|
|
11/13 (84.62%)
|
|
15/24 (62.50%)
|
|
17/27 (62.96%)
|
|
1/8 (12.50%)
|
|
9/19 (47.37%)
|
|
58/103 (56.31%)
|
|
|
|
Phase 1: Dose Escalation: QOD Dosing: 8 mg
|
Phase 1: Dose Escalation: QOD Dosing: 16 mg
|
Phase 1: Dose Escalation: QOD Dosing: 24 mg
|
Phase 1: Dose Escalation: QOD Dosing: 36 mg
|
Phase 1: Dose Escalation: QOD Dosing: 56 mg
|
Phase 1: Dose Escalation: QOD Dosing: 80 mg
|
Phase 1: Dose Escalation: QOD Dosing: 120 mg
|
Phase 1: Dose Escalation: QOD Dosing: 160 mg
|
Phase 1: Dose Escalation: QOD Dosing: 200 mg
|
Phase 1: Dose Escalation: QD Dosing: 4 mg
|
Phase 1: Dose Escalation: QD Dosing: 8 mg
|
Phase 1: Dose Escalation: QD Dosing: 16 mg
|
Phase 1: Dose Escalation: QD Dosing: 20 mg
|
Phase 1: Dose Escalation: QD Dosing: 24 mg
|
Phase 1: Dose Expansion Cohort 1
|
Phase 1: Dose Expansion: Cohort 2
|
Phase 1: Dose Expansion: Cohort 3
|
Phase 1: Dose Expansion: Cohort 4
|
Phase 1: Dose Expansion: Cohort 5
|
Phase 1: Dose Expansion: Cohort 6
|
Phase 1: Dose Expansion: Sub-cohort 2
|
Phase 1: Dose Expansion: Sub-cohort 1
|
Phase 2
|
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Total |
1/6 (16.67%)
|
|
0/3 (0.00%)
|
|
1/3 (33.33%)
|
|
1/3 (33.33%)
|
|
1/3 (33.33%)
|
|
2/5 (40.00%)
|
|
4/4 (100.00%)
|
|
7/8 (87.50%)
|
|
4/7 (57.14%)
|
|
0/4 (0.00%)
|
|
1/5 (20.00%)
|
|
9/14 (64.29%)
|
|
3/7 (42.86%)
|
|
6/14 (42.86%)
|
|
27/57 (47.37%)
|
|
13/34 (38.24%)
|
|
10/15 (66.67%)
|
|
9/13 (69.23%)
|
|
13/24 (54.17%)
|
|
14/27 (51.85%)
|
|
0/8 (0.00%)
|
|
0/19 (0.00%)
|
|
42/103 (40.78%)
|
|
Blood and lymphatic system disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Anaemia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
|
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
2 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
2 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
3 |
Cardiac disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Acute myocardial infarction |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
1 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Atrial fibrillation |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Ventricular tachycardia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Eye disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Cataract |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
2 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Ocular ischaemic syndrome |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Papilloedema |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Retinal detachment |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
1 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Gastrointestinal disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Abdominal pain |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
2/8 (25.00%)
|
2 |
1/7 (14.29%)
|
1 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
3/57 (5.26%)
|
3 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
1/24 (4.17%)
|
2 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Abdominal pain upper |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
1 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Ascites |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
4/103 (3.88%)
|
4 |
Colitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
2/57 (3.51%)
|
2 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Colonic pseudo-obstruction |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Constipation |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Duodenal obstruction |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Dysphagia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Gastric haemorrhage |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
1 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Gastrointestinal haemorrhage |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
2 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Haematemesis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/7 (14.29%)
|
2 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Haematochezia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Ileus |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
1 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Impaired gastric emptying |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
2 |
Inguinal hernia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
1 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Intestinal obstruction |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
2/57 (3.51%)
|
2 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
2/24 (8.33%)
|
3 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Melaena |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Nausea |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/4 (25.00%)
|
1 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/7 (14.29%)
|
2 |
1/14 (7.14%)
|
1 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Obstruction gastric |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Oesophageal ulcer |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Oesophageal varices haemorrhage |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Oesophagitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
3 |
Oesophagitis ulcerative |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Pancreatitis acute |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
2 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Small intestinal haemorrhage |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
2 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Stomatitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
1 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Umbilical hernia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Upper gastrointestinal haemorrhage |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
3/103 (2.91%)
|
4 |
Vomiting |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/4 (25.00%)
|
1 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/7 (14.29%)
|
2 |
1/14 (7.14%)
|
1 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
General disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Asthenia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
1 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Death |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Disease progression |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
2/7 (28.57%)
|
2 |
1/14 (7.14%)
|
1 |
2/57 (3.51%)
|
2 |
0/34 (0.00%)
|
0 |
3/15 (20.00%)
|
3 |
2/13 (15.38%)
|
2 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
2 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
5/103 (4.85%)
|
6 |
Fatigue |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
1 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Gait disturbance |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
General physical health deterioration |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
1/34 (2.94%)
|
1 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Non-cardiac chest pain |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Pyrexia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
4/103 (3.88%)
|
4 |
Suprapubic pain |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Hepatobiliary disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Bile duct obstruction |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
3/103 (2.91%)
|
3 |
Bile duct stenosis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Cholangitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
2 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
1 |
1/27 (3.70%)
|
3 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
2 |
Cholangitis acute |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Cholecystitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Gallbladder obstruction |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Hepatic failure |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
2/57 (3.51%)
|
2 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Jaundice |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Portal vein thrombosis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Infections and infestations |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Appendicitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Biliary sepsis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Biliary tract infection |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
2/57 (3.51%)
|
2 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Bronchitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
2 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Cellulitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
2 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Corona virus infection |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Cystitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Gastroenteritis viral |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Infection |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Lower respiratory tract infection |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Lung infection |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Paronychia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Peritonitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Peritonitis bacterial |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Pharyngitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Pneumonia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Sepsis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/14 (0.00%)
|
0 |
3/57 (5.26%)
|
3 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
3/27 (11.11%)
|
3 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
2/103 (1.94%)
|
2 |
Splenic abscess |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Urinary tract infection |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
2/103 (1.94%)
|
4 |
Urosepsis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Wound infection |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Injury, poisoning and procedural complications |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Fall |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
2/103 (1.94%)
|
2 |
Femur fracture |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Humerus fracture |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Muscle strain |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Overdose |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
2/103 (1.94%)
|
3 |
Post procedural fever |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
2 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Rib fracture |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Spinal compression fracture |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Subdural haematoma |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Wound haemorrhage |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Investigations |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Alanine aminotransferase increased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Aspartate aminotransferase increased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Blood bilirubin increased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
2/57 (3.51%)
|
2 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Gamma-glutamyltransferase increased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Nuclear magnetic resonance imaging brain abnormal |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Troponin T increased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Metabolism and nutrition disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Decreased appetite |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
2 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
2/103 (1.94%)
|
2 |
Dehydration |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
1/7 (14.29%)
|
1 |
0/14 (0.00%)
|
0 |
2/57 (3.51%)
|
2 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
2/103 (1.94%)
|
2 |
Failure to thrive |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Hypercalcaemia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/4 (25.00%)
|
1 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Hyperkalaemia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Hypoglycaemia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Hyponatraemia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Musculoskeletal and connective tissue disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Arthralgia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Back pain |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Bone pain |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Haemarthrosis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Muscular weakness |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Myalgia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Pain in extremity |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Neoplasms benign, malignant and unspecified (incl cysts and polyps) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Colon cancer metastatic |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Malignant ascites |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Malignant neoplasm progression |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Malignant pleural effusion |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Metastases to central nervous system |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Oncologic complication |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Tumour associated fever |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Tumour pain |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
2/103 (1.94%)
|
2 |
Nervous system disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Altered state of consciousness |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Aphasia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Cerebral ischaemia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Cognitive disorder |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Dizziness |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Dysarthria |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Extrapyramidal disorder |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Focal dyscognitive seizures |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Guillain-Barre syndrome |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Headache |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
2/34 (5.88%)
|
3 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Hemiparesis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/4 (25.00%)
|
1 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
2/34 (5.88%)
|
3 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Hepatic encephalopathy |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
2 |
Intracranial mass |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Migraine |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
2/103 (1.94%)
|
2 |
Nervous system disorder |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Neurological symptom |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Paraesthesia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Presyncope |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Seizure |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Spinal cord compression |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
1 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Subarachnoid haemorrhage |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Transient ischaemic attack |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
1/4 (25.00%)
|
1 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
2/103 (1.94%)
|
2 |
Psychiatric disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Confusional state |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Disorientation |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Mental status changes |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Renal and urinary disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Acute kidney injury |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
2/57 (3.51%)
|
2 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Hydronephrosis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Urinary incontinence |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Urinary retention |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Respiratory, thoracic and mediastinal disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Aspiration |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Dyspnoea |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
2 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
2/103 (1.94%)
|
2 |
Epistaxis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Pleural effusion |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Pneumonitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Pneumothorax |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Pulmonary embolism |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Pulmonary thrombosis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Respiratory distress |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/4 (25.00%)
|
1 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Respiratory failure |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Vascular disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Deep vein thrombosis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
1/34 (2.94%)
|
1 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
2 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Hypertension |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Hypotension |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Jugular vein thrombosis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Term from vocabulary, MedDRA 17.0, 22.0
Indicates events were collected by systematic assessment
|
|
Frequency Threshold for Reporting Other Adverse Events
|
5%
|
|
Phase 1: Dose Escalation: QOD Dosing: 8 mg
|
Phase 1: Dose Escalation: QOD Dosing: 16 mg
|
Phase 1: Dose Escalation: QOD Dosing: 24 mg
|
Phase 1: Dose Escalation: QOD Dosing: 36 mg
|
Phase 1: Dose Escalation: QOD Dosing: 56 mg
|
Phase 1: Dose Escalation: QOD Dosing: 80 mg
|
Phase 1: Dose Escalation: QOD Dosing: 120 mg
|
Phase 1: Dose Escalation: QOD Dosing: 160 mg
|
Phase 1: Dose Escalation: QOD Dosing: 200 mg
|
Phase 1: Dose Escalation: QD Dosing: 4 mg
|
Phase 1: Dose Escalation: QD Dosing: 8 mg
|
Phase 1: Dose Escalation: QD Dosing: 16 mg
|
Phase 1: Dose Escalation: QD Dosing: 20 mg
|
Phase 1: Dose Escalation: QD Dosing: 24 mg
|
Phase 1: Dose Expansion Cohort 1
|
Phase 1: Dose Expansion: Cohort 2
|
Phase 1: Dose Expansion: Cohort 3
|
Phase 1: Dose Expansion: Cohort 4
|
Phase 1: Dose Expansion: Cohort 5
|
Phase 1: Dose Expansion: Cohort 6
|
Phase 1: Dose Expansion: Sub-cohort 2
|
Phase 1: Dose Expansion: Sub-cohort 1
|
Phase 2
|
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Affected / at Risk (%) |
# Events
|
Total |
6/6 (100.00%)
|
|
3/3 (100.00%)
|
|
3/3 (100.00%)
|
|
3/3 (100.00%)
|
|
3/3 (100.00%)
|
|
5/5 (100.00%)
|
|
4/4 (100.00%)
|
|
8/8 (100.00%)
|
|
7/7 (100.00%)
|
|
4/4 (100.00%)
|
|
5/5 (100.00%)
|
|
14/14 (100.00%)
|
|
7/7 (100.00%)
|
|
14/14 (100.00%)
|
|
57/57 (100.00%)
|
|
34/34 (100.00%)
|
|
15/15 (100.00%)
|
|
13/13 (100.00%)
|
|
23/24 (95.83%)
|
|
26/27 (96.30%)
|
|
8/8 (100.00%)
|
|
19/19 (100.00%)
|
|
103/103 (100.00%)
|
|
Blood and lymphatic system disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Anaemia |
2/6 (33.33%)
|
3 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
2 |
1/3 (33.33%)
|
1 |
1/5 (20.00%)
|
1 |
2/4 (50.00%)
|
3 |
4/8 (50.00%)
|
8 |
1/7 (14.29%)
|
1 |
1/4 (25.00%)
|
1 |
0/5 (0.00%)
|
0 |
2/14 (14.29%)
|
2 |
3/7 (42.86%)
|
3 |
3/14 (21.43%)
|
7 |
10/57 (17.54%)
|
14 |
4/34 (11.76%)
|
4 |
2/15 (13.33%)
|
2 |
3/13 (23.08%)
|
9 |
4/24 (16.67%)
|
10 |
5/27 (18.52%)
|
7 |
1/8 (12.50%)
|
4 |
2/19 (10.53%)
|
2 |
17/103 (16.50%)
|
36 |
Iron deficiency anaemia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Lymphadenopathy mediastinal |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
0/103 (0.00%)
|
0 |
Lymphopenia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
2/34 (5.88%)
|
2 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
4 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
2 |
4/103 (3.88%)
|
5 |
Neutropenia |
0/6 (0.00%)
|
0 |
1/3 (33.33%)
|
2 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
5 |
3/57 (5.26%)
|
6 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
1/24 (4.17%)
|
1 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
4/103 (3.88%)
|
6 |
Thrombocytopenia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/4 (25.00%)
|
1 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
1/7 (14.29%)
|
2 |
1/14 (7.14%)
|
1 |
3/57 (5.26%)
|
3 |
1/34 (2.94%)
|
2 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
2/24 (8.33%)
|
2 |
2/27 (7.41%)
|
2 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
12/103 (11.65%)
|
27 |
Increased tendency to bruise |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Lymph node pain |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Cardiac disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Palpitations |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
2/19 (10.53%)
|
3 |
0/103 (0.00%)
|
0 |
Tachycardia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
2/103 (1.94%)
|
2 |
Sinus tachycardia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Ear and labyrinth disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Hypoacusis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Tinnitus |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
1/8 (12.50%)
|
2 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Vertigo |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
2/34 (5.88%)
|
2 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
2/103 (1.94%)
|
4 |
Cerumen impaction |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Endocrine disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Hypopituitarism |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Hypothyroidism |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Eye disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Cataract |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
8/57 (14.04%)
|
16 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
3/13 (23.08%)
|
3 |
2/24 (8.33%)
|
3 |
2/27 (7.41%)
|
3 |
1/8 (12.50%)
|
1 |
1/19 (5.26%)
|
8 |
6/103 (5.83%)
|
6 |
Cataract nuclear |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
2/15 (13.33%)
|
2 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
0/103 (0.00%)
|
0 |
Cataract subcapsular |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Chorioretinopathy |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/4 (25.00%)
|
1 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
2/103 (1.94%)
|
2 |
Dry eye |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/4 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
2/14 (14.29%)
|
2 |
0/7 (0.00%)
|
0 |
2/14 (14.29%)
|
2 |
7/57 (12.28%)
|
7 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
2/13 (15.38%)
|
2 |
3/24 (12.50%)
|
4 |
5/27 (18.52%)
|
5 |
0/8 (0.00%)
|
0 |
2/19 (10.53%)
|
2 |
23/103 (22.33%)
|
28 |
Eye irritation |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Eye pain |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
3/103 (2.91%)
|
5 |
Growth of eyelashes |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
2/8 (25.00%)
|
2 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
3/57 (5.26%)
|
3 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
1/103 (0.97%)
|
1 |
Keratitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
2/57 (3.51%)
|
3 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
2/27 (7.41%)
|
3 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Lacrimation increased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
2 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
6/103 (5.83%)
|
6 |
Ocular hyperaemia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
1/103 (0.97%)
|
1 |
Ocular surface disease |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Pinguecula |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
0/103 (0.00%)
|
0 |
Punctate keratitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
1 |
1/27 (3.70%)
|
1 |
1/8 (12.50%)
|
2 |
0/19 (0.00%)
|
0 |
2/103 (1.94%)
|
5 |
Retinal detachment |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
2/24 (8.33%)
|
4 |
2/27 (7.41%)
|
2 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Subretinal fluid |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
3/103 (2.91%)
|
3 |
Trichiasis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
3/57 (5.26%)
|
3 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
2/103 (1.94%)
|
2 |
Vision blurred |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
1/7 (14.29%)
|
1 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
1/7 (14.29%)
|
1 |
1/14 (7.14%)
|
1 |
8/57 (14.04%)
|
8 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
1 |
1/27 (3.70%)
|
1 |
1/8 (12.50%)
|
1 |
4/19 (21.05%)
|
4 |
8/103 (7.77%)
|
9 |
Visual impairment |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
2/8 (25.00%)
|
2 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
2/14 (14.29%)
|
2 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
4/103 (3.88%)
|
4 |
Vitreous detachment |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Xerophthalmia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Lacrimation decreased |
0/6 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Optic nerve cupping |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Photopsia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Visual acuity reduced |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Vitreous adhesions |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Vitreous floaters |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Gastrointestinal disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Abdominal discomfort |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
2/27 (7.41%)
|
2 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
1/103 (0.97%)
|
1 |
Abdominal distension |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
2/14 (14.29%)
|
2 |
3/57 (5.26%)
|
3 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
2/19 (10.53%)
|
2 |
6/103 (5.83%)
|
6 |
Abdominal pain |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/4 (25.00%)
|
1 |
1/8 (12.50%)
|
1 |
2/7 (28.57%)
|
2 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
3/14 (21.43%)
|
6 |
1/7 (14.29%)
|
1 |
1/14 (7.14%)
|
1 |
15/57 (26.32%)
|
22 |
5/34 (14.71%)
|
5 |
3/15 (20.00%)
|
3 |
1/13 (7.69%)
|
1 |
5/24 (20.83%)
|
9 |
3/27 (11.11%)
|
3 |
0/8 (0.00%)
|
0 |
2/19 (10.53%)
|
2 |
21/103 (20.39%)
|
28 |
Abdominal pain lower |
0/6 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Abdominal pain upper |
0/6 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
2/3 (66.67%)
|
2 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/4 (25.00%)
|
1 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
1/7 (14.29%)
|
1 |
0/14 (0.00%)
|
0 |
4/57 (7.02%)
|
8 |
2/34 (5.88%)
|
2 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
3/27 (11.11%)
|
4 |
0/8 (0.00%)
|
0 |
3/19 (15.79%)
|
3 |
8/103 (7.77%)
|
10 |
Anal inflammation |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
0/103 (0.00%)
|
0 |
Ascites |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
3/57 (5.26%)
|
4 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
4 |
4/103 (3.88%)
|
5 |
Constipation |
2/6 (33.33%)
|
2 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
2/4 (50.00%)
|
2 |
4/8 (50.00%)
|
10 |
1/7 (14.29%)
|
1 |
1/4 (25.00%)
|
1 |
1/5 (20.00%)
|
1 |
5/14 (35.71%)
|
11 |
3/7 (42.86%)
|
4 |
7/14 (50.00%)
|
10 |
18/57 (31.58%)
|
25 |
9/34 (26.47%)
|
11 |
6/15 (40.00%)
|
10 |
3/13 (23.08%)
|
4 |
9/24 (37.50%)
|
12 |
11/27 (40.74%)
|
15 |
1/8 (12.50%)
|
2 |
8/19 (42.11%)
|
10 |
40/103 (38.83%)
|
50 |
Diarrhoea |
0/6 (0.00%)
|
0 |
3/3 (100.00%)
|
3 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
1/5 (20.00%)
|
1 |
2/4 (50.00%)
|
5 |
6/8 (75.00%)
|
7 |
3/7 (42.86%)
|
6 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
5/14 (35.71%)
|
9 |
3/7 (42.86%)
|
3 |
7/14 (50.00%)
|
10 |
17/57 (29.82%)
|
19 |
13/34 (38.24%)
|
16 |
4/15 (26.67%)
|
7 |
3/13 (23.08%)
|
4 |
11/24 (45.83%)
|
17 |
10/27 (37.04%)
|
14 |
5/8 (62.50%)
|
7 |
5/19 (26.32%)
|
7 |
37/103 (35.92%)
|
65 |
Dry mouth |
2/6 (33.33%)
|
3 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
2/3 (66.67%)
|
2 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
3/4 (75.00%)
|
3 |
3/8 (37.50%)
|
3 |
2/7 (28.57%)
|
3 |
2/4 (50.00%)
|
2 |
1/5 (20.00%)
|
1 |
4/14 (28.57%)
|
4 |
1/7 (14.29%)
|
1 |
3/14 (21.43%)
|
3 |
13/57 (22.81%)
|
15 |
4/34 (11.76%)
|
4 |
3/15 (20.00%)
|
4 |
1/13 (7.69%)
|
1 |
3/24 (12.50%)
|
3 |
7/27 (25.93%)
|
7 |
0/8 (0.00%)
|
0 |
7/19 (36.84%)
|
7 |
36/103 (34.95%)
|
41 |
Dyspepsia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
4/57 (7.02%)
|
4 |
3/34 (8.82%)
|
5 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
2 |
3/27 (11.11%)
|
3 |
0/8 (0.00%)
|
0 |
3/19 (15.79%)
|
4 |
7/103 (6.80%)
|
8 |
Dysphagia |
0/6 (0.00%)
|
0 |
1/3 (33.33%)
|
3 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
2/34 (5.88%)
|
2 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
1/24 (4.17%)
|
1 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
5/103 (4.85%)
|
5 |
Flatulence |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
2 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Gastrointestinal haemorrhage |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
0/103 (0.00%)
|
0 |
Gastrooesophageal reflux disease |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
2/14 (14.29%)
|
2 |
7/57 (12.28%)
|
11 |
2/34 (5.88%)
|
2 |
2/15 (13.33%)
|
2 |
1/13 (7.69%)
|
2 |
3/24 (12.50%)
|
5 |
2/27 (7.41%)
|
2 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
6/103 (5.83%)
|
8 |
Haemorrhoidal haemorrhage |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Haemorrhoids |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
2 |
Intestinal obstruction |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Lip swelling |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Mouth ulceration |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
2/34 (5.88%)
|
2 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
1 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
4/103 (3.88%)
|
4 |
Nausea |
2/6 (33.33%)
|
2 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
2/5 (40.00%)
|
2 |
2/4 (50.00%)
|
4 |
3/8 (37.50%)
|
4 |
3/7 (42.86%)
|
4 |
1/4 (25.00%)
|
1 |
1/5 (20.00%)
|
1 |
4/14 (28.57%)
|
6 |
1/7 (14.29%)
|
1 |
5/14 (35.71%)
|
10 |
21/57 (36.84%)
|
30 |
4/34 (11.76%)
|
5 |
3/15 (20.00%)
|
3 |
4/13 (30.77%)
|
4 |
7/24 (29.17%)
|
7 |
13/27 (48.15%)
|
20 |
3/8 (37.50%)
|
3 |
8/19 (42.11%)
|
11 |
25/103 (24.27%)
|
38 |
Oesophageal pain |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
0/103 (0.00%)
|
0 |
Oral pain |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
2/13 (15.38%)
|
2 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
3/103 (2.91%)
|
4 |
Rectal haemorrhage |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
1/34 (2.94%)
|
1 |
1/15 (6.67%)
|
1 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Stomatitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
1/4 (25.00%)
|
2 |
2/8 (25.00%)
|
7 |
1/7 (14.29%)
|
1 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
5/14 (35.71%)
|
7 |
1/7 (14.29%)
|
1 |
3/14 (21.43%)
|
5 |
13/57 (22.81%)
|
28 |
3/34 (8.82%)
|
3 |
3/15 (20.00%)
|
3 |
2/13 (15.38%)
|
5 |
4/24 (16.67%)
|
10 |
2/27 (7.41%)
|
2 |
1/8 (12.50%)
|
2 |
7/19 (36.84%)
|
7 |
25/103 (24.27%)
|
56 |
Vomiting |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
2/4 (50.00%)
|
2 |
3/8 (37.50%)
|
4 |
2/7 (28.57%)
|
2 |
0/4 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
3/14 (21.43%)
|
4 |
2/7 (28.57%)
|
4 |
5/14 (35.71%)
|
7 |
15/57 (26.32%)
|
31 |
10/34 (29.41%)
|
14 |
1/15 (6.67%)
|
2 |
3/13 (23.08%)
|
3 |
5/24 (20.83%)
|
12 |
8/27 (29.63%)
|
13 |
0/8 (0.00%)
|
0 |
4/19 (21.05%)
|
5 |
20/103 (19.42%)
|
30 |
Cheilitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Epigastric discomfort |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Haematemesis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/7 (14.29%)
|
2 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Oesophagitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Proctalgia |
0/6 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Colonic pseudo-obstruction |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Gingival oedema |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Glossodynia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Proctitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
General disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Asthenia |
1/6 (16.67%)
|
1 |
2/3 (66.67%)
|
2 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
2 |
1/3 (33.33%)
|
1 |
1/5 (20.00%)
|
1 |
0/4 (0.00%)
|
0 |
2/8 (25.00%)
|
2 |
1/7 (14.29%)
|
2 |
1/4 (25.00%)
|
1 |
1/5 (20.00%)
|
2 |
4/14 (28.57%)
|
4 |
1/7 (14.29%)
|
1 |
2/14 (14.29%)
|
2 |
7/57 (12.28%)
|
10 |
7/34 (20.59%)
|
15 |
2/15 (13.33%)
|
2 |
0/13 (0.00%)
|
0 |
4/24 (16.67%)
|
4 |
6/27 (22.22%)
|
9 |
1/8 (12.50%)
|
1 |
1/19 (5.26%)
|
3 |
4/103 (3.88%)
|
7 |
Chills |
1/6 (16.67%)
|
3 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
3/57 (5.26%)
|
4 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
3/27 (11.11%)
|
6 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
4/103 (3.88%)
|
5 |
Fatigue |
1/6 (16.67%)
|
1 |
1/3 (33.33%)
|
1 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
2 |
1/4 (25.00%)
|
2 |
1/8 (12.50%)
|
6 |
1/7 (14.29%)
|
1 |
0/4 (0.00%)
|
0 |
1/5 (20.00%)
|
3 |
2/14 (14.29%)
|
2 |
1/7 (14.29%)
|
1 |
2/14 (14.29%)
|
3 |
12/57 (21.05%)
|
14 |
9/34 (26.47%)
|
12 |
4/15 (26.67%)
|
5 |
6/13 (46.15%)
|
6 |
8/24 (33.33%)
|
18 |
9/27 (33.33%)
|
15 |
2/8 (25.00%)
|
2 |
4/19 (21.05%)
|
5 |
36/103 (34.95%)
|
65 |
Influenza like illness |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
1/103 (0.97%)
|
1 |
Mucosal dryness |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
2/34 (5.88%)
|
2 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Non-cardiac chest pain |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
2 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
4/103 (3.88%)
|
4 |
Oedema peripheral |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
2/8 (25.00%)
|
2 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
8/57 (14.04%)
|
8 |
0/34 (0.00%)
|
0 |
3/15 (20.00%)
|
5 |
0/13 (0.00%)
|
0 |
2/24 (8.33%)
|
3 |
1/27 (3.70%)
|
2 |
0/8 (0.00%)
|
0 |
3/19 (15.79%)
|
3 |
15/103 (14.56%)
|
17 |
Pain |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
2/34 (5.88%)
|
2 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
3/103 (2.91%)
|
3 |
Peripheral swelling |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
2/19 (10.53%)
|
2 |
2/103 (1.94%)
|
2 |
Pyrexia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
1/5 (20.00%)
|
1 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
1/7 (14.29%)
|
1 |
1/4 (25.00%)
|
1 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
1/7 (14.29%)
|
1 |
1/14 (7.14%)
|
1 |
4/57 (7.02%)
|
5 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
2 |
2/24 (8.33%)
|
2 |
2/27 (7.41%)
|
2 |
0/8 (0.00%)
|
0 |
3/19 (15.79%)
|
3 |
11/103 (10.68%)
|
15 |
Xerosis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/4 (25.00%)
|
1 |
0/8 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
1/4 (25.00%)
|
1 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Device failure |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Disease progression |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
2/7 (28.57%)
|
2 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Face oedema |
0/6 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Gait disturbance |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Malaise |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Chest discomfort |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Chest pain |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Hepatobiliary disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Cholecystitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Hyperbilirubinaemia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
3/57 (5.26%)
|
6 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
2 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
3/103 (2.91%)
|
5 |
Bile duct stenosis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Bile duct obstruction |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Hepatic pain |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/4 (25.00%)
|
1 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Infections and infestations |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Bacteraemia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Bronchitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
2/34 (5.88%)
|
2 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Cellulitis |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
3/57 (5.26%)
|
3 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
2/103 (1.94%)
|
3 |
Cellulitis staphylococcal |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
0/103 (0.00%)
|
0 |
Conjunctivitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
2/57 (3.51%)
|
2 |
2/34 (5.88%)
|
2 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
3/103 (2.91%)
|
3 |
Cystitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
2/103 (1.94%)
|
2 |
Device related infection |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Gastroenteritis viral |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
0/103 (0.00%)
|
0 |
Herpes zoster |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
2/57 (3.51%)
|
2 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
1/19 (5.26%)
|
1 |
0/103 (0.00%)
|
0 |
Influenza |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
2/19 (10.53%)
|
2 |
0/103 (0.00%)
|
0 |
Lower respiratory tract infection |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
1 |
0/27 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Lung infection |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
1/24 (4.17%)
|
1 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
2/103 (1.94%)
|
2 |
Oral candidiasis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
2/19 (10.53%)
|
2 |
2/103 (1.94%)
|
2 |
Otitis media |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
1/103 (0.97%)
|
1 |
Paronychia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
2 |
1/7 (14.29%)
|
1 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
6 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
3/57 (5.26%)
|
8 |
1/34 (2.94%)
|
2 |
1/15 (6.67%)
|
1 |
1/13 (7.69%)
|
1 |
1/24 (4.17%)
|
1 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
5/19 (26.32%)
|
8 |
8/103 (7.77%)
|
18 |
Pharyngitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
3 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
2/103 (1.94%)
|
2 |
Pharyngitis streptococcal |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
0/103 (0.00%)
|
0 |
Sinusitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
2/57 (3.51%)
|
2 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
2/103 (1.94%)
|
2 |
Tooth infection |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
1 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
0/103 (0.00%)
|
0 |
Upper respiratory tract infection |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
4/57 (7.02%)
|
4 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
2 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
7/103 (6.80%)
|
7 |
Urinary tract infection |
0/6 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
1/3 (33.33%)
|
2 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
2/4 (50.00%)
|
2 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
5/57 (8.77%)
|
9 |
2/34 (5.88%)
|
3 |
3/15 (20.00%)
|
4 |
0/13 (0.00%)
|
0 |
2/24 (8.33%)
|
2 |
3/27 (11.11%)
|
5 |
2/8 (25.00%)
|
3 |
6/19 (31.58%)
|
7 |
20/103 (19.42%)
|
32 |
Urosepsis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Vulvovaginal mycotic infection |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
1/103 (0.97%)
|
1 |
Pneumonia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Folliculitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Localised infection |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Onychomycosis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Sepsis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Oral fungal infection |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Vaginal infection |
0/6 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Nasopharyngitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Bronchitis viral |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Oesophageal candidiasis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Pelvic abscess |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Stoma site infection |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Injury, poisoning and procedural complications |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Procedural pain |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Accidental overdose |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Burn oesophageal |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Fall |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Muscle rupture |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Post procedural haemorrhage |
0/6 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Post procedural oedema |
0/6 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Stoma site pain |
0/6 (0.00%)
|
0 |
1/3 (33.33%)
|
2 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Wound decomposition |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Wound haemorrhage |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Investigations |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Activated partial thromboplastin time prolonged |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
3/103 (2.91%)
|
3 |
Alanine aminotransferase increased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
3/7 (42.86%)
|
4 |
1/4 (25.00%)
|
1 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
3/7 (42.86%)
|
6 |
6/14 (42.86%)
|
10 |
12/57 (21.05%)
|
22 |
15/34 (44.12%)
|
39 |
2/15 (13.33%)
|
6 |
4/13 (30.77%)
|
12 |
6/24 (25.00%)
|
29 |
5/27 (18.52%)
|
12 |
1/8 (12.50%)
|
1 |
7/19 (36.84%)
|
10 |
18/103 (17.48%)
|
52 |
Aspartate aminotransferase increased |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
2/7 (28.57%)
|
3 |
1/4 (25.00%)
|
1 |
1/5 (20.00%)
|
1 |
1/14 (7.14%)
|
2 |
3/7 (42.86%)
|
4 |
5/14 (35.71%)
|
11 |
16/57 (28.07%)
|
33 |
8/34 (23.53%)
|
14 |
2/15 (13.33%)
|
3 |
5/13 (38.46%)
|
11 |
6/24 (25.00%)
|
18 |
9/27 (33.33%)
|
13 |
0/8 (0.00%)
|
0 |
7/19 (36.84%)
|
11 |
26/103 (25.24%)
|
60 |
Bilirubin conjugated increased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
2/27 (7.41%)
|
2 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Blood albumin decreased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Blood alkaline phosphatase increased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/7 (14.29%)
|
2 |
1/4 (25.00%)
|
2 |
1/5 (20.00%)
|
1 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
8/57 (14.04%)
|
19 |
3/34 (8.82%)
|
3 |
2/15 (13.33%)
|
2 |
2/13 (15.38%)
|
2 |
2/24 (8.33%)
|
4 |
3/27 (11.11%)
|
6 |
0/8 (0.00%)
|
0 |
4/19 (21.05%)
|
7 |
13/103 (12.62%)
|
25 |
Blood bilirubin increased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/14 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
2/14 (14.29%)
|
6 |
9/57 (15.79%)
|
19 |
2/34 (5.88%)
|
2 |
1/15 (6.67%)
|
2 |
1/13 (7.69%)
|
2 |
2/24 (8.33%)
|
5 |
1/27 (3.70%)
|
4 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
2 |
7/103 (6.80%)
|
20 |
Blood calcium increased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
1/34 (2.94%)
|
2 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
2/27 (7.41%)
|
3 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
2 |
1/103 (0.97%)
|
1 |
Blood creatine phosphokinase increased |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
5 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
4/57 (7.02%)
|
4 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
1 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
3/19 (15.79%)
|
3 |
10/103 (9.71%)
|
12 |
Blood creatinine increased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
3/8 (37.50%)
|
6 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
9/57 (15.79%)
|
14 |
2/34 (5.88%)
|
4 |
3/15 (20.00%)
|
8 |
1/13 (7.69%)
|
3 |
3/24 (12.50%)
|
3 |
3/27 (11.11%)
|
4 |
0/8 (0.00%)
|
0 |
5/19 (26.32%)
|
8 |
15/103 (14.56%)
|
30 |
Blood phosphorus increased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
4/57 (7.02%)
|
10 |
1/34 (2.94%)
|
4 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
3/27 (11.11%)
|
7 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
9/103 (8.74%)
|
30 |
Gamma-glutamyltransferase increased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
1/4 (25.00%)
|
1 |
1/5 (20.00%)
|
1 |
0/14 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
4 |
3/34 (8.82%)
|
3 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
1 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
2/103 (1.94%)
|
4 |
International normalised ratio increased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
2/103 (1.94%)
|
2 |
Lymphocyte count decreased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
2/34 (5.88%)
|
2 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
1 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
4/103 (3.88%)
|
9 |
Neutrophil count decreased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
2/19 (10.53%)
|
2 |
6/103 (5.83%)
|
6 |
Platelet count decreased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/14 (0.00%)
|
0 |
3/57 (5.26%)
|
4 |
2/34 (5.88%)
|
2 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
2 |
0/8 (0.00%)
|
0 |
2/19 (10.53%)
|
7 |
3/103 (2.91%)
|
6 |
Troponin T increased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
7/103 (6.80%)
|
8 |
Urine analysis abnormal |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
2/15 (13.33%)
|
3 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Weight decreased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
10/57 (17.54%)
|
15 |
2/34 (5.88%)
|
2 |
2/15 (13.33%)
|
3 |
1/13 (7.69%)
|
2 |
4/24 (16.67%)
|
5 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
3/19 (15.79%)
|
5 |
19/103 (18.45%)
|
29 |
Weight increased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
3/34 (8.82%)
|
4 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
3 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
2/103 (1.94%)
|
4 |
White blood cell count decreased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
2 |
6/103 (5.83%)
|
6 |
Lipase increased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
2/3 (66.67%)
|
3 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Platelet count increased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
2/3 (66.67%)
|
2 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Amylase increased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
3 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Blood creatine phosphokinase decreased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/4 (25.00%)
|
1 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Blood thyroid stimulating hormone increased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Electrocardiogram QT prolonged |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Gastric pH decreased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
2 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Electrocardiogram ST segment abnormal |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Metabolism and nutrition disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Calciphylaxis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
0/103 (0.00%)
|
0 |
Decreased appetite |
0/6 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
2/3 (66.67%)
|
2 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/4 (25.00%)
|
1 |
3/8 (37.50%)
|
3 |
2/7 (28.57%)
|
4 |
1/4 (25.00%)
|
2 |
2/5 (40.00%)
|
3 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
3/14 (21.43%)
|
3 |
10/57 (17.54%)
|
11 |
6/34 (17.65%)
|
6 |
4/15 (26.67%)
|
7 |
1/13 (7.69%)
|
1 |
7/24 (29.17%)
|
12 |
6/27 (22.22%)
|
8 |
1/8 (12.50%)
|
1 |
3/19 (15.79%)
|
4 |
23/103 (22.33%)
|
51 |
Dehydration |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
2/27 (7.41%)
|
2 |
0/8 (0.00%)
|
0 |
2/19 (10.53%)
|
2 |
6/103 (5.83%)
|
12 |
Hypercalcaemia |
1/6 (16.67%)
|
1 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/4 (25.00%)
|
2 |
1/8 (12.50%)
|
6 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
12/57 (21.05%)
|
19 |
2/34 (5.88%)
|
5 |
2/15 (13.33%)
|
3 |
2/13 (15.38%)
|
3 |
1/24 (4.17%)
|
2 |
4/27 (14.81%)
|
6 |
0/8 (0.00%)
|
0 |
4/19 (21.05%)
|
6 |
16/103 (15.53%)
|
30 |
Hyperglycaemia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
3/57 (5.26%)
|
5 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
2/27 (7.41%)
|
3 |
0/8 (0.00%)
|
0 |
2/19 (10.53%)
|
4 |
4/103 (3.88%)
|
5 |
Hyperkalaemia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
2 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
3 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
3 |
3/103 (2.91%)
|
5 |
Hyperphosphataemia |
0/6 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
1/3 (33.33%)
|
3 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
4/5 (80.00%)
|
7 |
3/4 (75.00%)
|
6 |
6/8 (75.00%)
|
16 |
6/7 (85.71%)
|
10 |
1/4 (25.00%)
|
1 |
2/5 (40.00%)
|
2 |
9/14 (64.29%)
|
11 |
6/7 (85.71%)
|
7 |
12/14 (85.71%)
|
33 |
48/57 (84.21%)
|
220 |
30/34 (88.24%)
|
108 |
9/15 (60.00%)
|
22 |
12/13 (92.31%)
|
36 |
19/24 (79.17%)
|
74 |
21/27 (77.78%)
|
58 |
5/8 (62.50%)
|
19 |
17/19 (89.47%)
|
71 |
88/103 (85.44%)
|
537 |
Hyperuricaemia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
2/13 (15.38%)
|
2 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Hypoalbuminaemia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/4 (25.00%)
|
1 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
6/103 (5.83%)
|
15 |
Hypocalcaemia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
2/103 (1.94%)
|
2 |
Hypokalaemia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
2 |
1/4 (25.00%)
|
1 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
1/4 (25.00%)
|
1 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
6/57 (10.53%)
|
6 |
2/34 (5.88%)
|
4 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
3/27 (11.11%)
|
4 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
6/103 (5.83%)
|
10 |
Hypomagnesaemia |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
2/5 (40.00%)
|
3 |
1/4 (25.00%)
|
1 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/4 (25.00%)
|
1 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
3/19 (15.79%)
|
3 |
3/103 (2.91%)
|
3 |
Hyponatraemia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
8 |
2/4 (50.00%)
|
4 |
1/8 (12.50%)
|
1 |
1/7 (14.29%)
|
1 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/7 (14.29%)
|
2 |
1/14 (7.14%)
|
1 |
3/57 (5.26%)
|
4 |
1/34 (2.94%)
|
2 |
1/15 (6.67%)
|
1 |
2/13 (15.38%)
|
3 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
2 |
0/8 (0.00%)
|
0 |
3/19 (15.79%)
|
4 |
17/103 (16.50%)
|
32 |
Hypophosphataemia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
4 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/14 (0.00%)
|
0 |
10/57 (17.54%)
|
22 |
2/34 (5.88%)
|
2 |
0/15 (0.00%)
|
0 |
2/13 (15.38%)
|
3 |
1/24 (4.17%)
|
2 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
2/19 (10.53%)
|
2 |
14/103 (13.59%)
|
21 |
Hypovolaemia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Failure to thrive |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Hypophagia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Musculoskeletal and connective tissue disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Arthralgia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
2/8 (25.00%)
|
2 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
10/57 (17.54%)
|
20 |
3/34 (8.82%)
|
5 |
1/15 (6.67%)
|
1 |
2/13 (15.38%)
|
3 |
2/24 (8.33%)
|
2 |
2/27 (7.41%)
|
2 |
1/8 (12.50%)
|
1 |
3/19 (15.79%)
|
3 |
23/103 (22.33%)
|
32 |
Back pain |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
1/14 (7.14%)
|
1 |
2/7 (28.57%)
|
2 |
1/14 (7.14%)
|
1 |
6/57 (10.53%)
|
8 |
2/34 (5.88%)
|
3 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
2/24 (8.33%)
|
3 |
1/27 (3.70%)
|
1 |
1/8 (12.50%)
|
2 |
5/19 (26.32%)
|
6 |
17/103 (16.50%)
|
21 |
Bone pain |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Joint swelling |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
2/27 (7.41%)
|
2 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
2 |
Muscle spasms |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
2/14 (14.29%)
|
2 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
5/57 (8.77%)
|
8 |
3/34 (8.82%)
|
3 |
2/15 (13.33%)
|
3 |
1/13 (7.69%)
|
1 |
1/24 (4.17%)
|
1 |
2/27 (7.41%)
|
2 |
0/8 (0.00%)
|
0 |
2/19 (10.53%)
|
3 |
15/103 (14.56%)
|
21 |
Muscular weakness |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
4/34 (11.76%)
|
5 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
1 |
1/27 (3.70%)
|
2 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
2/103 (1.94%)
|
3 |
Musculoskeletal chest pain |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
3/57 (5.26%)
|
3 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
2/24 (8.33%)
|
2 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
2/19 (10.53%)
|
2 |
2/103 (1.94%)
|
2 |
Musculoskeletal pain |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
1/7 (14.29%)
|
1 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
2/57 (3.51%)
|
2 |
1/34 (2.94%)
|
2 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
2/24 (8.33%)
|
2 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
3/19 (15.79%)
|
3 |
6/103 (5.83%)
|
8 |
Myalgia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
4/57 (7.02%)
|
8 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
2/27 (7.41%)
|
2 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
15/103 (14.56%)
|
24 |
Neck pain |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
2 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
2 |
1/103 (0.97%)
|
1 |
Pain in extremity |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/14 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/14 (0.00%)
|
0 |
3/57 (5.26%)
|
10 |
2/34 (5.88%)
|
2 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
2 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
5/19 (26.32%)
|
10 |
9/103 (8.74%)
|
13 |
Tendonitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
1 |
0/27 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
1/19 (5.26%)
|
1 |
0/103 (0.00%)
|
0 |
Dactylitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Groin pain |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Musculoskeletal stiffness |
0/6 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Osteolysis |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Pain in jaw |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Flank pain |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Neoplasms benign, malignant and unspecified (incl cysts and polyps) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Cancer pain |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
1/8 (12.50%)
|
2 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Skin papilloma |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
2/19 (10.53%)
|
2 |
2/103 (1.94%)
|
2 |
Tumour haemorrhage |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Tumour pain |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
2/13 (15.38%)
|
3 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
5/103 (4.85%)
|
5 |
Infected neoplasm |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Nervous system disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Ageusia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
2/34 (5.88%)
|
2 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Balance disorder |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
1/34 (2.94%)
|
1 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Dizziness |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
2/14 (14.29%)
|
2 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
7/57 (12.28%)
|
9 |
2/34 (5.88%)
|
2 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
5/19 (26.32%)
|
7 |
10/103 (9.71%)
|
11 |
Dysgeusia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
2/8 (25.00%)
|
2 |
1/7 (14.29%)
|
1 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
3/14 (21.43%)
|
3 |
7/57 (12.28%)
|
8 |
2/34 (5.88%)
|
2 |
2/15 (13.33%)
|
4 |
0/13 (0.00%)
|
0 |
3/24 (12.50%)
|
3 |
3/27 (11.11%)
|
4 |
0/8 (0.00%)
|
0 |
3/19 (15.79%)
|
3 |
21/103 (20.39%)
|
27 |
Headache |
2/6 (33.33%)
|
2 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/4 (0.00%)
|
0 |
3/8 (37.50%)
|
6 |
1/7 (14.29%)
|
1 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
5/57 (8.77%)
|
12 |
6/34 (17.65%)
|
6 |
2/15 (13.33%)
|
2 |
1/13 (7.69%)
|
1 |
3/24 (12.50%)
|
4 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
4/19 (21.05%)
|
6 |
8/103 (7.77%)
|
13 |
Hemiparesis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
4/34 (11.76%)
|
6 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Hypoaesthesia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
4/57 (7.02%)
|
5 |
4/34 (11.76%)
|
4 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
7/103 (6.80%)
|
9 |
Memory impairment |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
1/103 (0.97%)
|
1 |
Migraine |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
2/103 (1.94%)
|
3 |
Neuropathy peripheral |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/4 (0.00%)
|
0 |
2/8 (25.00%)
|
2 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
2/14 (14.29%)
|
2 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
3/57 (5.26%)
|
3 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
2/13 (15.38%)
|
2 |
1/24 (4.17%)
|
1 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
6/103 (5.83%)
|
7 |
Paraesthesia |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
2/7 (28.57%)
|
2 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
2/14 (14.29%)
|
2 |
2/57 (3.51%)
|
3 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
1/8 (12.50%)
|
1 |
0/19 (0.00%)
|
0 |
5/103 (4.85%)
|
6 |
Peripheral sensory neuropathy |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
4/57 (7.02%)
|
5 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
1 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
10/103 (9.71%)
|
15 |
Seizure |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
2/34 (5.88%)
|
2 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Taste disorder |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
2 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
1 |
2/27 (7.41%)
|
2 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
4/103 (3.88%)
|
4 |
Tremor |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
3/103 (2.91%)
|
3 |
Cognitive disorder |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Aphasia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Ataxia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Disturbance in attention |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Dysarthria |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Encephalopathy |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/4 (25.00%)
|
1 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Migraine with aura |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Partial seizures |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/7 (14.29%)
|
2 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Somnolence |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Nervous system disorder |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Peroneal nerve palsy |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Psychiatric disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Anxiety |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
2/57 (3.51%)
|
2 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
2/13 (15.38%)
|
2 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
2/103 (1.94%)
|
2 |
Confusional state |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
2/8 (25.00%)
|
2 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
2/34 (5.88%)
|
2 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
2/8 (25.00%)
|
2 |
1/19 (5.26%)
|
1 |
5/103 (4.85%)
|
5 |
Insomnia |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
5/57 (8.77%)
|
6 |
2/34 (5.88%)
|
2 |
0/15 (0.00%)
|
0 |
2/13 (15.38%)
|
2 |
1/24 (4.17%)
|
3 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
3/19 (15.79%)
|
4 |
8/103 (7.77%)
|
9 |
Onychophagia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Agitation |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Delirium |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/4 (25.00%)
|
1 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Depression |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Hallucination |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Libido decreased |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Renal and urinary disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Acute kidney injury |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
1/103 (0.97%)
|
1 |
Bladder prolapse |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
2 |
0/103 (0.00%)
|
0 |
Dysuria |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
2/14 (14.29%)
|
2 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
1/13 (7.69%)
|
1 |
1/24 (4.17%)
|
1 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
5/103 (4.85%)
|
5 |
Haematuria |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
2 |
0/34 (0.00%)
|
0 |
2/15 (13.33%)
|
2 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
2/103 (1.94%)
|
3 |
Pollakiuria |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
1/103 (0.97%)
|
3 |
Proteinuria |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
1/34 (2.94%)
|
1 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
4 |
Renal failure |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
1 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
0/103 (0.00%)
|
0 |
Urinary retention |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
2/34 (5.88%)
|
2 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Micturition disorder |
0/6 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Reproductive system and breast disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Benign prostatic hyperplasia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Pelvic pain |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
4 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
1/103 (0.97%)
|
1 |
Vulvovaginal dryness |
0/6 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
1 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
0/103 (0.00%)
|
0 |
Breast ulceration |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Ovarian vein thrombosis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Vaginal haemorrhage |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Respiratory, thoracic and mediastinal disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Acute pulmonary oedema |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Cough |
0/6 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/4 (25.00%)
|
1 |
0/5 (0.00%)
|
0 |
2/14 (14.29%)
|
2 |
0/7 (0.00%)
|
0 |
2/14 (14.29%)
|
2 |
3/57 (5.26%)
|
3 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
2/24 (8.33%)
|
2 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
2/19 (10.53%)
|
2 |
4/103 (3.88%)
|
4 |
Dysphonia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
1/103 (0.97%)
|
1 |
Dyspnoea |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
3/14 (21.43%)
|
3 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
4/57 (7.02%)
|
4 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
2/13 (15.38%)
|
3 |
5/24 (20.83%)
|
5 |
4/27 (14.81%)
|
6 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
4/103 (3.88%)
|
6 |
Dyspnoea exertional |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Epistaxis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
2/14 (14.29%)
|
2 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
3/57 (5.26%)
|
3 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
4/19 (21.05%)
|
4 |
7/103 (6.80%)
|
8 |
Hiccups |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
2/34 (5.88%)
|
2 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
3/103 (2.91%)
|
3 |
Hypoxia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
2 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Nasal congestion |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
4/103 (3.88%)
|
6 |
Oropharyngeal dysplasia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Oropharyngeal pain |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
3/34 (8.82%)
|
3 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
1 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
2/19 (10.53%)
|
2 |
10/103 (9.71%)
|
10 |
Pleural effusion |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
1/19 (5.26%)
|
1 |
0/103 (0.00%)
|
0 |
Pneumothorax |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
2/103 (1.94%)
|
2 |
Pulmonary embolism |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Rhinitis allergic |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
0/103 (0.00%)
|
0 |
Throat irritation |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Upper-airway cough syndrome |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
1/103 (0.97%)
|
1 |
Dry throat |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Haemoptysis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Hypoventilation |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Nasal dryness |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Pleurisy |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Rhinalgia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Skin and subcutaneous tissue disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Alopecia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
3/8 (37.50%)
|
3 |
1/7 (14.29%)
|
1 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
2/14 (14.29%)
|
2 |
1/7 (14.29%)
|
1 |
3/14 (21.43%)
|
3 |
18/57 (31.58%)
|
23 |
5/34 (14.71%)
|
7 |
3/15 (20.00%)
|
3 |
0/13 (0.00%)
|
0 |
5/24 (20.83%)
|
5 |
2/27 (7.41%)
|
2 |
0/8 (0.00%)
|
0 |
3/19 (15.79%)
|
3 |
35/103 (33.98%)
|
41 |
Blister |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
2/19 (10.53%)
|
2 |
1/103 (0.97%)
|
1 |
Decubitus ulcer |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Dermatitis allergic |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
2 |
0/103 (0.00%)
|
0 |
Dermatitis contact |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
2/19 (10.53%)
|
2 |
0/103 (0.00%)
|
0 |
Dry skin |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
1/3 (33.33%)
|
1 |
1/5 (20.00%)
|
1 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
2/7 (28.57%)
|
2 |
0/4 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
3/14 (21.43%)
|
3 |
0/7 (0.00%)
|
0 |
2/14 (14.29%)
|
2 |
11/57 (19.30%)
|
11 |
2/34 (5.88%)
|
3 |
1/15 (6.67%)
|
1 |
1/13 (7.69%)
|
1 |
3/24 (12.50%)
|
3 |
4/27 (14.81%)
|
5 |
0/8 (0.00%)
|
0 |
7/19 (36.84%)
|
7 |
30/103 (29.13%)
|
39 |
Erythema |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
2/57 (3.51%)
|
2 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
2/103 (1.94%)
|
2 |
Hypertrichosis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
3/19 (15.79%)
|
3 |
1/103 (0.97%)
|
1 |
Itching scar |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
0/103 (0.00%)
|
0 |
Nail bed disorder |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
0/103 (0.00%)
|
0 |
Nail discolouration |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
1/7 (14.29%)
|
1 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
4/57 (7.02%)
|
4 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
2/19 (10.53%)
|
2 |
14/103 (13.59%)
|
20 |
Nail disorder |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/4 (25.00%)
|
1 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/7 (0.00%)
|
0 |
2/14 (14.29%)
|
2 |
3/57 (5.26%)
|
5 |
0/34 (0.00%)
|
0 |
2/15 (13.33%)
|
2 |
0/13 (0.00%)
|
0 |
3/24 (12.50%)
|
7 |
3/27 (11.11%)
|
3 |
1/8 (12.50%)
|
1 |
1/19 (5.26%)
|
1 |
16/103 (15.53%)
|
20 |
Nail hypertrophy |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
1/103 (0.97%)
|
1 |
Nail ridging |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
0/103 (0.00%)
|
0 |
Onychalgia |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
3/57 (5.26%)
|
8 |
1/34 (2.94%)
|
2 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
3/103 (2.91%)
|
3 |
Onycholysis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/4 (25.00%)
|
1 |
2/8 (25.00%)
|
3 |
2/7 (28.57%)
|
2 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
6/57 (10.53%)
|
9 |
1/34 (2.94%)
|
1 |
1/15 (6.67%)
|
2 |
0/13 (0.00%)
|
0 |
3/24 (12.50%)
|
3 |
2/27 (7.41%)
|
2 |
0/8 (0.00%)
|
0 |
3/19 (15.79%)
|
3 |
16/103 (15.53%)
|
24 |
Onychomadesis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
4/57 (7.02%)
|
5 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
2/19 (10.53%)
|
3 |
15/103 (14.56%)
|
19 |
Palmar-plantar erythrodysaesthesia syndrome |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/4 (0.00%)
|
0 |
2/8 (25.00%)
|
3 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
2/14 (14.29%)
|
3 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
2 |
15/57 (26.32%)
|
38 |
2/34 (5.88%)
|
4 |
3/15 (20.00%)
|
5 |
1/13 (7.69%)
|
1 |
1/24 (4.17%)
|
8 |
2/27 (7.41%)
|
2 |
1/8 (12.50%)
|
1 |
6/19 (31.58%)
|
19 |
22/103 (21.36%)
|
87 |
Palmoplantar keratoderma |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
0/103 (0.00%)
|
0 |
Papule |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Plantar erythema |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
3/57 (5.26%)
|
3 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Pruritus |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
2/3 (66.67%)
|
2 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
1/4 (25.00%)
|
1 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
3/57 (5.26%)
|
3 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
1/24 (4.17%)
|
1 |
2/27 (7.41%)
|
2 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
9/103 (8.74%)
|
12 |
Rash |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
2 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
2/57 (3.51%)
|
2 |
1/34 (2.94%)
|
1 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
2/24 (8.33%)
|
2 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
3/19 (15.79%)
|
5 |
5/103 (4.85%)
|
6 |
Rash maculo-papular |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
2/57 (3.51%)
|
4 |
2/34 (5.88%)
|
2 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
2/103 (1.94%)
|
4 |
Skin hypertrophy |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
2/19 (10.53%)
|
2 |
0/103 (0.00%)
|
0 |
Skin mass |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
3/57 (5.26%)
|
4 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Swelling face |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Xeroderma |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Onychoclasis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Pain of skin |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/7 (14.29%)
|
1 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Skin exfoliation |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
1 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
1/14 (7.14%)
|
1 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Dermatitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
2 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Hyperhidrosis |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Nail bed tenderness |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Nail dystrophy |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Night sweats |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Rash macular |
0/6 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Skin fissures |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/5 (20.00%)
|
2 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Skin haemorrhage |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Skin ulcer |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Urticaria |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
1/3 (33.33%)
|
1 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Urticaria contact |
1/6 (16.67%)
|
1 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Vascular disorders |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Hot flush |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
1/19 (5.26%)
|
1 |
0/103 (0.00%)
|
0 |
Hypertension |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
1/8 (12.50%)
|
1 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
1/15 (6.67%)
|
2 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
1/27 (3.70%)
|
1 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
6/103 (5.83%)
|
19 |
Hypotension |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
2/7 (28.57%)
|
4 |
1/14 (7.14%)
|
1 |
4/57 (7.02%)
|
7 |
1/34 (2.94%)
|
1 |
0/15 (0.00%)
|
0 |
1/13 (7.69%)
|
1 |
1/24 (4.17%)
|
1 |
2/27 (7.41%)
|
3 |
0/8 (0.00%)
|
0 |
4/19 (21.05%)
|
6 |
4/103 (3.88%)
|
6 |
Phlebitis |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
1/57 (1.75%)
|
1 |
2/34 (5.88%)
|
2 |
1/15 (6.67%)
|
1 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Venous thrombosis limb |
0/6 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/3 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
1/4 (25.00%)
|
1 |
0/8 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/4 (0.00%)
|
0 |
0/5 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/7 (0.00%)
|
0 |
0/14 (0.00%)
|
0 |
0/57 (0.00%)
|
0 |
0/34 (0.00%)
|
0 |
0/15 (0.00%)
|
0 |
0/13 (0.00%)
|
0 |
0/24 (0.00%)
|
0 |
0/27 (0.00%)
|
0 |
0/8 (0.00%)
|
0 |
0/19 (0.00%)
|
0 |
0/103 (0.00%)
|
0 |
Term from vocabulary, MedDRA 17.0, 22.0
Indicates events were collected by systematic assessment
|