Platine, Avastin and OLAparib in 1st Line (PAOLA-1)

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ClinicalTrials.gov Identifier: NCT02477644

Recruitment Status : Completed

First Posted : June 23, 2015

Last Update Posted : August 2, 2022

View this study on the modernized ClinicalTrials.gov

Sponsor:

Collaborators:

Arbeitsgemeinschaft Gynaekologishe Onkologie Germany

Arbeitsgemeinschaft Gynaekologische Onkologie Austria

Grupo Español de Investigación en Cáncer de Ovario

Belgian Gynaecological Oncology Group

Multicenter Italian Trials in Ovarian cancer and gynecologic malignancies

Mario Negri Gynecologic Oncology group (MaNGO)

Nordic Society of Gynaecological Oncology - Clinical Trials Unit

Gynecologic Oncology Trial & Investigation Consortium

Information provided by (Responsible Party):

Arcagy Research

No Study Results Posted on ClinicalTrials.gov for this Study

About Study Results Reporting on ClinicalTrials.gov

Recruitment Status :	Completed
Actual Primary Completion Date :	March 22, 2019
Actual Study Completion Date :	March 22, 2022

Publications of Results:

Ray-Coquard I, Pautier P, Pignata S, Perol D, Gonzalez-Martin A, Berger R, Fujiwara K, Vergote I, Colombo N, Maenpaa J, Selle F, Sehouli J, Lorusso D, Guerra Alia EM, Reinthaller A, Nagao S, Lefeuvre-Plesse C, Canzler U, Scambia G, Lortholary A, Marme F, Combe P, de Gregorio N, Rodrigues M, Buderath P, Dubot C, Burges A, You B, Pujade-Lauraine E, Harter P; PAOLA-1 Investigators. Olaparib plus Bevacizumab as First-Line Maintenance in Ovarian Cancer. N Engl J Med. 2019 Dec 19;381(25):2416-2428. doi: 10.1056/NEJMoa1911361.

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Gonzalez-Martin A, Desauw C, Heitz F, Cropet C, Gargiulo P, Berger R, Ochi H, Vergote I, Colombo N, Mirza MR, Tazi Y, Canzler U, Zamagni C, Guerra-Alia EM, Levache CB, Marme F, Bazan F, de Gregorio N, Dohollou N, Fasching PA, Scambia G, Rubio-Perez MJ, Milenkova T, Costan C, Pautier P, Ray-Coquard I; PAOLA1/ENGOT-ov25 investigators. Maintenance olaparib plus bevacizumab in patients with newly diagnosed advanced high-grade ovarian cancer: Main analysis of second progression-free survival in the phase III PAOLA-1/ENGOT-ov25 trial. Eur J Cancer. 2022 Oct;174:221-231. doi: 10.1016/j.ejca.2022.07.022. Epub 2022 Sep 5.

Fujiwara K, Fujiwara H, Yoshida H, Satoh T, Yonemori K, Nagao S, Matsumoto T, Kobayashi H, Bourgeois H, Harter P, Mosconi AM, Vazquez IP, Reinthaller A, Fujita T, Rowe P, Pujade-Lauraine E, Ray-Coquard I. Olaparib plus bevacizumab as maintenance therapy in patients with newly diagnosed, advanced ovarian cancer: Japan subset from the PAOLA-1/ENGOT-ov25 trial. J Gynecol Oncol. 2021 Sep;32(5):e82. doi: 10.3802/jgo.2021.32.e82.

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