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Trial record 77 of 350 for:    Gastrointestinal Stromal Tumors
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A Retrospective Clinical Records Review of Patients Diagnosed With Gastrointestinal Stromal Tumour at Two Tertiary Institutes in Singapore

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ClinicalTrials.gov Identifier: NCT00718211
Recruitment Status : Completed
First Posted : July 18, 2008
Last Update Posted : March 30, 2020
Sponsor:
Information provided by (Responsible Party):
National University Hospital, Singapore

Study Description
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Brief Summary:
To review the characteristics and treatment of gastrointestinal tumours at the two tertiary centres in Singapore

Condition or disease
Gastrointestinal Stromal Tumors

Detailed Description:

A retrospective clinical records review of patients diagnosed with gastrointestinal stromal tumour (GIST) in the two tertiary centres in Singapore i.e. Singapore General Hospital and National University Hospital.

Gastrointestinal tumours are the most common soft-tissue tumours of the gastrointestinal tracts. Remarkable progress has been made during the last several years in the diagnosis and treatment of GIST. Understanding of the molecular pathogenesis of GIST which is linked to deregulated KIT tyrosine-kinase activity has improved diagnosis, such that GIST is now more frequently and specifically identified. More importantly, systemic tyrosine kinase inhibitor, imatinib, has been used successfully in the treatment of GIST patients with advanced or unresectable disease.

GIST has been reviewed in the Western literature but there is a lack of Asian data. The review will help us to better understand the disease in our population.Furthermore we will also examine several unresolved issues in the Western literature by looking into our local data. These include required duration of imatinib therapy, role of imatinib in the adjuvant setting (application of chemotherapy after macroscopically complete removal of tumour) and role of combination therapies.

The medical records of all patients diagnosed with the disease at the two centres will be reviewed.

Analysis of the results aims to:

  1. to compare the characteristics of the GIST (epidemiology, site, morphology, immunohistochemistry profile) in our centres compared to the well-published literature.
  2. to compare the treatment regimen and results of our centres compared to others
  3. to review the role of chemotherapy in the adjuvant settings in the centres.
Study Design
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Study Type : Observational
Official Title: A Retrospective Clinical Records Review of Patients Diagnosed With Gastrointestinal Stromal Tumour at Two Tertiary Institutes in Singapore.
Study Start Date : May 2006
Actual Primary Completion Date : September 2013

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Groups and Cohorts
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Outcome Measures
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Eligibility Criteria
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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

To review medical records of all patients diagnosed with the disease at the two specified centres.

The medical records will be obtained through both paper and electronic medical systems.

All data will be contained in a password secured database and will be securely located behind institutional firewalls.

Criteria

Inclusion Criteria:

  • Patients diagnosed with Gastrointestinal stromal tumor.
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00718211


Locations
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Singapore
National University Hospital
Singapore, Singapore
Sponsors and Collaborators
National University Hospital, Singapore
Investigators
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Principal Investigator: Ross Andrew Soo, MBBS National University Hospital, Singapore
More Information
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Responsible Party: National University Hospital, Singapore
ClinicalTrials.gov Identifier: NCT00718211    
Other Study ID Numbers: GA01/12/06
First Posted: July 18, 2008    Key Record Dates
Last Update Posted: March 30, 2020
Last Verified: January 2014
Additional relevant MeSH terms:
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Gastrointestinal Stromal Tumors
Neoplasms, Connective Tissue
Neoplasms, Connective and Soft Tissue
Neoplasms by Histologic Type
Neoplasms
 Gastrointestinal Neoplasms
Digestive System Neoplasms
Digestive System Diseases
Gastrointestinal Diseases