Trial record 33 of 41 for:
dental stem cells | United States
Bone Regeneration Using Bone Marrow Stromal Cells
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| ClinicalTrials.gov Identifier: NCT00001391 |
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Recruitment Status :
Completed
First Posted : November 4, 1999
Last Update Posted : July 2, 2017
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Sponsor:
National Institute of Dental and Craniofacial Research (NIDCR)
Information provided by:
National Institutes of Health Clinical Center (CC)
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Brief Summary:
Deficient or inappropriate healing of bone impacts clinical decision-making and treatment options in orthopedics, oral and maxillofacial surgery, plastic surgery and periodontics. While a number of auto- and allografting techniques have been used to regenerate craniofacial defects caused by infective, neoplastic or trauma-induced bone loss, each method has significant limitations. Our research group in the Craniofacial and Skeletal Diseases Branch of NIDCR has developed methods to culture and expand cell populations derived from mouse bone marrow stroma. We believe that an important next step is to apply the information gained in animal studies to treat osseous defects in humans. We propose to examine the potential of cultured human bone marrow stromal cells to serve as an abundant source of osteoblastic progenitor cells. These cells will ultimately be used to graft craniofacial osseous defects. In the course of this study we will: (1) develop methods for the propagation and enrichment of osteoblastic progenitor cells from bone marrow stroma; (2) test various vehicles for the transfer of bone marrow stromal cells to osseous defects in recipient animals; (3) determine optimal culturing and transplantation conditions for the eventual transplantation of bone marrow stromal cells into human recipients. These studies will define the parameters of bone marrow stromal cell transplantation and will generate models for future therapeutic strategies.
| Condition or disease |
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| Bone Disease Craniofacial Abnormality Healthy |
Deficient or inappropriate healing of bone impacts clinical decision-making and treatment options in orthopedics, oral and maxillofacial surgery, plastic surgery and periodontics. While a number of auto- and allografting techniques have been used to regenerate craniofacial defects caused by infective, neoplastic or trauma-induced bone loss, each method has significant limitations. Our research group in the Craniofacial and Skeletal Diseases Branch of NIDCR has developed methods to culture and expand cell populations derived from mouse bone marrow stroma. We believe that an important next step is to apply the information gained in animal studies to treat osseous defects in humans. We propose to examine the potential of cultured human bone marrow stromal cells to serve as an abundant source of osteoblastic progenitor cells. These cells will ultimately be used to graft craniofacial osseous defects. In the course of this study we will: (1) develop methods for the propagation and enrichment of osteoblastic progenitor cells from bone marrow stroma; (2) test various vehicles for the transfer of bone marrow stromal cells to osseous defects in recipient animals; (3) determine optimal culturing and transplantation conditions for the eventual transplantation of bone marrow stromal cells into human recipients. These studies will define the parameters of bone marrow stromal cell transplantation and will generate models for future therapeutic strategies.
| Study Type : | Observational |
| Actual Enrollment : | 54 participants |
| Official Title: | Bone Regeneration Using Bone Marrow Stromal Cells |
| Study Start Date : | August 3, 1994 |
| Study Completion Date : | October 4, 2010 |
Information from the National Library of Medicine
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| Ages Eligible for Study: | 18 Years to 70 Years (Adult, Older Adult) |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | Yes |
Criteria
- INCLUSION CRITERIA:
Males and females 18 years and older.
EXCLUSION CRITERIA:
Subjects may not have metabolic bone diseases, pregnancy or taking drugs affecting skeletal metabolism.
Information from the National Library of Medicine
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00001391
Locations
| United States, Maryland | |
| National Institutes of Health Clinical Center, 9000 Rockville Pike | |
| Bethesda, Maryland, United States, 20892 | |
Sponsors and Collaborators
National Institute of Dental and Craniofacial Research (NIDCR)
Publications:
| ClinicalTrials.gov Identifier: | NCT00001391 |
| Other Study ID Numbers: |
940188 94-D-0188 |
| First Posted: | November 4, 1999 Key Record Dates |
| Last Update Posted: | July 2, 2017 |
| Last Verified: | October 4, 2010 |
Keywords provided by National Institutes of Health Clinical Center (CC):
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Augmentation Osteogenesis Stem Cells Bone Formation Bone Induction |
Additional relevant MeSH terms:
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Bone Diseases Craniofacial Abnormalities Congenital Abnormalities Musculoskeletal Diseases Musculoskeletal Abnormalities |