Protein and microRNA Markers for Early Detection of Alzheimer's Disease
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ClinicalTrials.gov Identifier: NCT03388242 |
Recruitment Status :
Withdrawn
(The research group is too busy to do this study.)
First Posted : January 2, 2018
Last Update Posted : June 23, 2023
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Condition or disease | Intervention/treatment |
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Mild Cognitive Impairment | Other: No intervention |
Study Type : | Observational |
Actual Enrollment : | 0 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | Screen and Verification of Biomarkers for Early Detection of Alzheimer's Disease |
Actual Study Start Date : | December 7, 2017 |
Estimated Primary Completion Date : | March 30, 2020 |
Estimated Study Completion Date : | March 30, 2020 |
Group/Cohort | Intervention/treatment |
---|---|
Normal control people
These people are age-matched with the patients with MCI. No intervention is applied.
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Other: No intervention
Patients will be recruited into the study in their initial visit before patients are on any drug treatments for their AD or MCI. The study does not include use of any interventions. |
Patients with MCI
These patients have met the criteria for diagnosing MCI. No intervention is applied.
|
Other: No intervention
Patients will be recruited into the study in their initial visit before patients are on any drug treatments for their AD or MCI. The study does not include use of any interventions. |
Patients with AD
These patients are diagnosed with AD. No intervention is applied.
|
Other: No intervention
Patients will be recruited into the study in their initial visit before patients are on any drug treatments for their AD or MCI. The study does not include use of any interventions. |
- Fold changes of microRNAs in the blood of Patients with MCI over control people. [ Time Frame: Patients with MCI and AD will be evaluated every 6 month for 1.5 years to monitor the changes in their cognition and the expression patterns of microRNAs and proteins. ]serum and plasma will be used in the screen.
- Fold changes of proteins in the blood of Patients with MCI over control people. [ Time Frame: Patients with MCI and AD will be evaluated every 6 month for 1.5 years to monitor the changes in their cognition and the expression patterns of microRNAs and proteins. ]serum and plasma will be used in the screen.
Biospecimen Retention: Samples Without DNA
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Ages Eligible for Study: | 30 Years to 80 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Age-matched with patients with MCI group
Exclusion Criteria:
- With cognitive dysfunction
- With major cardiovascular diseases, especially stroke and brain transient ischemic attack
- On steroid treatment
- with major organ diseases
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03388242
China, Guangdong | |
Third Affiliated Hospital of Sun Yat-Sen University | |
Guangzhou, Guangdong, China, 510000 | |
Sun Yat-Sen Memorial Hospital | |
Guangzhou, Guangdong, China, 510120 |
Principal Investigator: | Zhiyi Zuo, MD, Ph.D. | Sun Yat-sen University |
Responsible Party: | Zhiyi Zuo, Visiting Professor, Sun Yat-sen University |
ClinicalTrials.gov Identifier: | NCT03388242 |
Other Study ID Numbers: |
SYSEC-KY-060 |
First Posted: | January 2, 2018 Key Record Dates |
Last Update Posted: | June 23, 2023 |
Last Verified: | June 2023 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | No |
Plan Description: | We will NOT share individual participant data with other researchers. |
Studies a U.S. FDA-regulated Drug Product: | No |
Studies a U.S. FDA-regulated Device Product: | No |
Alzheimer Disease Cognitive Dysfunction Dementia Brain Diseases Central Nervous System Diseases Nervous System Diseases |
Tauopathies Neurodegenerative Diseases Neurocognitive Disorders Mental Disorders Cognition Disorders |